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Cytokine response in the postoperative period after surgical treatment of benign adnexal masses: comparison between laparoscopy and laparotomy

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Abstract

Background

Cytokines are the main mediators of the inflammation and the response to trauma. The purpose of the present study was the comparative assessment in sera of patients with benign adnexal masses treated by laparoscopy or laparotomy of the following proinflammatory and anti-inflammatory cytokines: interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), and IL-10 in the early postoperative period.

Methods

A total of 40 patients with benign adnexal masses were studied; 25 of whom underwent laparoscopy and 15, laparotomy. Blood serum concentration of IL-1β, IL-6, IL-8, TNF-α, and IL-10 were measured by commercially available ELISA assays before and 4 h, 24 h, and 48 h after the operation.

Results

Concentrations of IL-6 were significantly increased in both groups at 4 h, 24 h, and 48 h after the surgery; levels of IL-10 showed a significant increase 4 h and 24 h after the operation; an increase in IL-1β levels was observed only after laparotomy; no significant variations were observed in serum levels of IL-8; the postoperative increase of IL-1β, IL-6, and IL-10 levels was more pronounced in patients undergoing laparotomy than in those treated laparoscopically; length of the surgical procedure, amount of CO2 used, tumor diameter, age, and body mass index (BMI) of the patients did not influence the postoperative patterns of the studied cytokines.

Conclusions

Systemic cytokine response after operations for benign adnexal masses depends on the degree of the surgical trauma, and is less pronounced in patients undergoing laparoscopy.

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Acknowledgments

The authors thank Professor Tomasz Rechberger, MD, PhD, Chief, II Department of Gynecology, Medical University of Lublin, Poland, for invaluable help and cooperation during the course of this study.

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Authors and Affiliations

  1. Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-094, Lublin, Poland

    A. Torres, K. Torres, G. J. Staśkiewicz & R. Maciejewski

  2. III Department of Gynecology, Medical University of Lublin, Jaczewskiego 8, 20-094, Lublin, Poland

    A. Torres & T. Paszkowski

  3. General Surgery Department, District Specialist Hospital of Lublin, Krasnicka 100, Lublin, Poland

    K. Torres

  4. I Department of Radiology, Medical University of Lublin, Jaczewskiego 8, 20-094, Lublin, Poland

    G. J. Staśkiewicz

  5. II Department of Surgery, Medical University of Lublin, Staszica 1, 20-950, Lublin, Poland

    R. Maciejewski

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  1. A. Torres
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Correspondence to A. Torres.

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Torres, A., Torres, K., Paszkowski, T. et al. Cytokine response in the postoperative period after surgical treatment of benign adnexal masses: comparison between laparoscopy and laparotomy. Surg Endosc 21, 1841–1848 (2007). https://doi.org/10.1007/s00464-007-9260-6

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