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NiCo2O4/Ti2NbC2 (double MXene) nanohybrid-based non-enzymatic electrochemical biosensor for the detection of glucose in sweat

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Abstract

The non-enzymatic electrochemical sensors are attractive due to their high sensitivity, quick detection, low cost, and simple construction. Hence, in this work, a non-enzymatic biosensor was constructed with NiCo2O4 nanoparticles (~ 82 nm) decorated over Ti2NbC2 nanosheets by an in-situ method. The crystal structure, phase purity, morphology and elemental composition of the synthesized NiCo2O4/Ti2NbC2 nanohybrid was investigated using XRD, Raman and FESEM analysis. The electrocatalytic and electrochemical behaviour of the prepared nanohybrid was investigated using cyclic voltammetry and amperometry analysis. Hybrid of NiCo2O4/Ti2NbC2 produces a biocompatible, electrochemically active surface with enhanced electrical conductivity. The enhanced surface area of NiCo2O4 and superior electrical conductivity of Ti2NbC2 nanosheets helped to develop non-enzymatic electrochemical glucose sensor with enhanced sensitivity (425.6 µA mM−1cm−2), low limit of detection and quick response time that satisfy glucose detection applications. Thus, the developed non-enzymatic electrochemical glucose sensor has excellent electrochemical properties and making it as a strong candidate for the detection of glucose concentration in sweat.

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Acknowledgements

The authors gratefully acknowledge Central Instrumentation Facility, Pondicherry University for extending their instrumentation facilities.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Saveetha Engineering College, Chennai, 602105, India

    Ashok Kumar Subramania, Sivanandam Sugumaran, Prakash Sethuramalingam & Rajasekaran Ramesh

  2. Centre for Nanoscience and Technology, Pondicherry University, Puducherry, 605014, India

    Preethi Dhandapani & Subramania Angaiah

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  1. Ashok Kumar Subramania
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  2. Sivanandam Sugumaran
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  3. Prakash Sethuramalingam
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  4. Rajasekaran Ramesh
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  5. Preethi Dhandapani
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  6. Subramania Angaiah
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Correspondence to Sivanandam Sugumaran or Subramania Angaiah.

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Subramania, A.K., Sugumaran, S., Sethuramalingam, P. et al. NiCo2O4/Ti2NbC2 (double MXene) nanohybrid-based non-enzymatic electrochemical biosensor for the detection of glucose in sweat. Bioprocess Biosyst Eng 46, 1755–1763 (2023). https://doi.org/10.1007/s00449-023-02930-0

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