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Control of cultivation processes for recombinant protein production: a review

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Abstract

The current state-of-the-art in control of cultivation processes for recombinant protein production is examined including the quantitative knowledge that can be activated for this purpose and the measurement techniques that can be employed for control at industrial manufacturing sites.

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Acknowledgments

The work was generously supported by the state of “Sachsen-Anhalt”, Germany during several projects entitled Wachstumskerne, Exzellenzcluster, etc. We thank them for this support over long years.

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Authors and Affiliations

  1. Institute for Biochemistry and Biotechnology, Martin-Luther University, Halle-Wittenberg, Germany

    Stefan Gnoth, Marco Jenzsch & Andreas Lübbert

  2. Institute of Automation and Control Systems, Kaunas University of Technology, Kaunas, Lithuania

    Rimvydas Simutis

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  1. Stefan Gnoth
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Correspondence to Andreas Lübbert.

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Gnoth, S., Jenzsch, M., Simutis, R. et al. Control of cultivation processes for recombinant protein production: a review. Bioprocess Biosyst Eng 31, 21–39 (2008). https://doi.org/10.1007/s00449-007-0163-7

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