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Stem cell-derived exosomes for chronic wound repair

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Abstract

Stem cells possess the capability of self-renewal and multipotency, which endows them with great application potential in wound repair fields. Yet, several problems including immune concerns, ethical debates, and oncogenicity impede the broad and deep advance of stem cell-based products. Recently, owing to their abundant resources, excellent biocompatibility, and ease of being engineered, stem cell-derived exosomes were proved to be promising nanomedicine for curing chronic wounds. What is more, stem cell-derived exosomes are almost the mini record of their maternal cells, which even equipped them with the unique characteristics of stem cells. Chronic wound healing efficacy is dominated by several complicated factors, especially the excessive inflammation conditions and impaired vessels. Therefore, this review tries to concentrate on the current advances of stem cell-derived exosomes for reducing inflammation and promoting angiogenesis in chronic wound healing processes. Last but not least, the existing limitations and future perspectives of stem cell-derived exosomes for chronic wound treatment are also outlined.

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Funding

This work was supported by Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases (No: PT022205, Hubei Minzu University).

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Author notes

  1. Peng Mi and Jia-Lin Liu contributed equally.

Authors and Affiliations

  1. School of Chemistry and Environmental Engineering, Wuhan Polytechnic University, Changqing Garden, Wuhan, 430023, Hubei, China

    Peng Mi, Jia-Lin Liu, Ben-Mei Wei, Cheng-Zhi Xu & Lian Zhu

  2. Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Hubei Minzu University, Enshi, 445000, Hubei, China

    Bao-Ping Qi

  3. School of Chemistry and Environmental Engineering, Hubei Minzu University, Xueyuan Road, Enshi, 445000, Hubei, China

    Bao-Ping Qi

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  1. Peng Mi
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Mi, P., Liu, JL., Qi, BP. et al. Stem cell-derived exosomes for chronic wound repair. Cell Tissue Res 391, 419–423 (2023). https://doi.org/10.1007/s00441-023-03742-0

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