Abstract
Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and remodeling is tightly regulated; however, hyperactivation of matrix metalloproteases (MMPs) contributes to excessive collagenolysis under pathologic conditions resulting in tendon ECM degradation. This review article focuses on the production, function, and signaling of matrikines for tendon regeneration following injury with insights into the expression, tissue compliance, and cell proliferation exhibited by various matrikines. Furthermore, the regenerative properties suggest translational significance of matrikines to improve the outcomes post-injury by assisting with tendon healing.
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The research work of F. G. Thankam is supported by the intramural funds of Western University of Health Sciences, Pomona, CA, USA. D. K. Agrawal is supported by research grants R01 HL144125 and R01 HL147662 from the National Institutes of Health, USA. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Mohindra, R., Mohindra, R., Agrawal, D.K. et al. Bioactive extracellular matrix fragments in tendon repair. Cell Tissue Res 390, 131–140 (2022). https://doi.org/10.1007/s00441-022-03684-z
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DOI: https://doi.org/10.1007/s00441-022-03684-z