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The role of IL-1β in Pseudomonas aeruginosa in lung infection

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Abstract

This mini-review examines the role of the pro-inflammatory cytokine interleukin (IL)-1β in the interaction of Pseudomonas aeruginosa and the host immune system during lung infection. Different studies show that the reduction of the inflammatory response, especially a decrease in IL-1β, leads to a better outcome in acute lung infection with this bacterium. This includes a higher survival rate, reduced damage to the lung tissue and, in particular, a better clearance of the airways and the tissue of the lungs from P. aeruginosa.

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Acknowledgment

The authors thank Ann Söther for editing help.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Saarland University, Kirrberger Strasse, 66424, Homburg, Saar, Germany

    B. Wonnenberg & T. Tschernig

  2. Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany

    M. Bischoff

  3. Department of Internal Medicine V, Pneumology, Allergology and Respiratory Critical Care Medicine, Saarland University, Homburg, Germany

    C. Beisswenger & R. Bals

  4. Department of Experimental Pneumology and Allergology, Saarland University, Homburg, Germany

    T. Dinh

  5. Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada

    B. Singh

Authors
  1. B. Wonnenberg
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  2. M. Bischoff
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  3. C. Beisswenger
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  4. T. Dinh
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  5. R. Bals
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  6. B. Singh
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  7. T. Tschernig
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Corresponding author

Correspondence to T. Tschernig.

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Wonnenberg, B., Bischoff, M., Beisswenger, C. et al. The role of IL-1β in Pseudomonas aeruginosa in lung infection. Cell Tissue Res 364, 225–229 (2016). https://doi.org/10.1007/s00441-016-2387-9

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  • DOI: https://doi.org/10.1007/s00441-016-2387-9

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