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New components of the Golgi matrix

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Abstract

The eukaryotic Golgi apparatus is characterized by a stack of flattened cisternae that are surrounded by transport vesicles. The organization and function of the Golgi require Golgi matrix proteins, including GRASPs and golgins, which exist primarily as fiber-like bridges between Golgi cisternae or between cisternae and vesicles. In this review, we highlight recent findings on Golgi matrix proteins, including their roles in maintaining the Golgi structure, vesicle tethering, and novel, unexpected functions. These new discoveries further our understanding of the molecular mechanisms that maintain the structure and the function of the Golgi, as well as its relationship with other cellular organelles such as the centrosome.

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Acknowledgments

The authors would like to thank members of the Wang Lab for suggestions and for critical reading of the manuscript. The authors declare no conflicts of interest.

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  1. Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI, 48109–1048, USA

    Yi Xiang & Yanzhuang Wang

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  1. Yi Xiang
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  2. Yanzhuang Wang
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Correspondence to Yanzhuang Wang.

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This work was supported by the National Institutes of Health (GM087364) and the American Cancer Society (RGS-09-278-01-CSM) to Y. Wang and a University of Michigan Rackham Predoctoral Fellowship to Y. Xiang.

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Xiang, Y., Wang, Y. New components of the Golgi matrix. Cell Tissue Res 344, 365–379 (2011). https://doi.org/10.1007/s00441-011-1166-x

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