Akey JM, Zhang K, Xiong M, Doris P, Jin L (2001) The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures. Am J Hum Genet 68:1447–1456
PubMed
CAS
Article
Google Scholar
Altman D, Moher D (2005) Developing guidelines for reporting healthcare research: scientific rationale and procedures. Med Clin (Barc) 125:8–13
Google Scholar
Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gotzsche PC, Lang T, CONSORT GROUP (Consolidated Standards of Reporting Trials) (2001) The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134:663–694
PubMed
CAS
Google Scholar
Anonymous (2005) Framework for a fully powered risk engine. Nat Genet 37:1153
Article
CAS
Google Scholar
Antonarakis SE (1998) Recommendations for a nomenclature system for human gene mutations. Nomenclature Working Group Hum Mutat 11:1–3
CAS
Google Scholar
Ardlie KG, Lunetta KL, Seielstad M (2002) Testing for population subdivision and association in four case–control studies. Am J Hum Genet 71:304–311
PubMed
CAS
Article
Google Scholar
Ayres KL, Balding DJ (1998) Measuring departures from Hardy–Weinberg: a Markov chain Monte Carlo method for estimating the inbreeding coefficient. Heredity 80(Pt 6):769–777
PubMed
Article
Google Scholar
Balding DJ (2006) A tutorial on statistical methods for population association studies. Nat Rev Genet 7:781–791
PubMed
CAS
Article
Google Scholar
Begg CB (2005) Reflections on publication criteria for genetic association studies. Cancer Epidemiol Biomarkers Prev 14:1364–1365
PubMed
Article
Google Scholar
Bogardus ST Jr, Concato J, Feinstein AR (1999) Clinical epidemiological quality in molecular genetic research. The need for methodological standards. J Am Med Assoc 281:1919–1926
Article
Google Scholar
Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FCP, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-kremer S, Stewart J, Taylor R, Vilo J, Vingron M (2001) Minimum information about a microarray experiment (MIAME)—toward standards for microarray data. Nat Genet 29:356–371
Article
CAS
Google Scholar
Browning SR (2008) Missing data imputation and haplotype phase inference for genome-wide association studies. Hum Genet 124:439–450
PubMed
CAS
Article
Google Scholar
Byrnes G, Gurrin L, Dowty J, Hopper JL (2005) Publication policy or publication bias? Cancer Epidemiol Biomarkers Prev 14:1363
PubMed
Article
Google Scholar
Cardon LR, Abecasis GR (2003) Using haplotype blocks to map human complex triat loci. Trends Genet 19:135–140
PubMed
CAS
Article
Google Scholar
Cardon L, Bell J (2001) Association study designs for complex diseases. Nat Rev Genet 2:91–99
PubMed
CAS
Article
Google Scholar
Cardon LR, Palmer LJ (2003) Population stratification and spurious allelic association. Lancet 361:598–604
PubMed
Article
Google Scholar
Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analysis using linkage disequilibrium. Am J Hum Genet 74:106–120
PubMed
CAS
Article
Google Scholar
Chan AW, Altman DG (2005) Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors. Br Med J 330:753
Article
Google Scholar
Chan AW, Hrobjartsson A, Haahr MT, Gotzsche PC, Altman DG (2004a) Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. J Am Med Assoc 291:2457–2465
CAS
Article
Google Scholar
Chan AW, Krleza-Jeric K, Schmid I, Altman DG (2004b) Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research. Can Med Assoc J 171:735–740
Article
Google Scholar
Clark MF, Baudouin SV (2006) A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med 32:1706–1712
PubMed
Article
Google Scholar
Clayton DG, Walker NM, Smyth DJ, Pask R, Cooper JD, Maier LM, Smink LJ, Lam AC, Ovington NR, Stevens HE, Nutland S, Howson JM, Faham M, Moorhead M, Jones HB, Falkowski M, Hardenbol P, Willis TD, Todd JA (2005) Population structure, differential bias and genomic control in a large-scale, case–control association study. Nat Genet 37:1243–1246
PubMed
CAS
Article
Google Scholar
Colhoun HM, McKeigue PM, Davey Smith G (2003) Problems of reporting genetic associations with complex outcomes. Lancet 361:865–872
PubMed
Article
Google Scholar
Contopoulos-Ioannidis DG, Alexiou GA, Gouvias TC, Ioannidis JP (2006) An empirical evaluation of multifarious outcomes in pharmacogenetics: beta-2 adrenoceptor gene polymorphisms in asthma treatment. Pharmacogenet Genomics 16:705–711
PubMed
CAS
Article
Google Scholar
Cooper DN, Nussbaum RL, Krawczak M (2002) Proposed guidelines for papers describing DNA polymorphism-disease associations. Hum Genet 110:208
Google Scholar
Crossman D, Watkins H (2004) Jesting Pilate, genetic case–control association studies, and heart. Heart 90:831–832
PubMed
CAS
Article
Google Scholar
Davidoff F, Batalden P, Stevens D, Ogrinc G, Mooney S, SQUIRE DevelopmentGroup (2008) Publication guidelines for improvement studies in health care: evolution of the SQUIRE Project. Ann Intern Med 149:670–676
PubMed
Google Scholar
DeLisi LE, Faraone SV (2006) When is a “positive” association truly a “positive” in psychiatric genetics? A commentary based on issues debated at the World Congress of Psychiatric Genetics, Boston, 12–18 October 2005. Am J Med Genet B Neuropsychiatr Genet 141:319–322
Google Scholar
den Dunnen JT, Antonarakis SE (2000) Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat 15:7–12
Article
Google Scholar
Dequeker E, Ramsden S, Grody WW, Stenzel TT, Barton DE (2001) Quality control in molecular genetic testing. Nat Rev Genet 2:717–723
PubMed
CAS
Article
Google Scholar
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Bostrom K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjogren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331–1336
PubMed
CAS
Article
Google Scholar
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461–1463
PubMed
CAS
Article
Google Scholar
Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, SEARCH collaborators, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, Fletcher O, Johnson N, Seal S, Stratton MR, Rahman N, Chenevix-Trench G, Bojesen SE, Nordestgaard BG, Axelsson CK, Garcia-Closas M, Brinton L, Chanock S, Lissowska J, Peplonska B, Nevanlinna H, Fagerholm R, Eerola H, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P, Wedren S, Liu J, Low YL, Bogdanova N, Schurmann P, Dork T, Tollenaar RA, Jacobi CE, Devilee P, Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J, Cox A, Brock IW, MacPherson G, Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H, van den Ouweland A, Uitterlinden A, Rivadeneira F, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Hopper JL, McCredie M, Southey M, Giles GG, Schroen C, Justenhoven C, Brauch H, Hamann U, Ko YD, Spurdle AB, Beesley J, Chen X, kConFab, AOCS Management Group, Mannermaa A, Kosma VM, Kataja V, Hartikainen J, Day NE, Cox DR, Ponder BA (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447:1087–1093
PubMed
CAS
Article
Google Scholar
Edland SD, Slager S, Farrer M (2004) Genetic association studies in Alzheimer’s disease research: challenges and opportunities. Stat Med 23:169–178
PubMed
Article
Google Scholar
Ehm MG, Nelson MR, Spurr NK (2005) Guidelines for conducting and reporting whole genome/large-scale association studies. Hum Mol Genet 14:2485–2488
PubMed
CAS
Article
Google Scholar
Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D (2004) Assessing the impact of population stratification on genetic association studies. Nat Genet 36:388–393
PubMed
CAS
Article
Google Scholar
Freimer NB, Sabatti C (2005) Guidelines for association studies in human molecular genetics. Hum Mol Genet 14:2481–2483
PubMed
CAS
Article
Google Scholar
Garcia-Closas M, Wacholder S, Caporaso N, Rothman N (2004) Inference issues in cohort and case–control studies of genetic effects and gene–environment interactions. In: Khoury MJ, Little J, Burke W (eds) Human genome epidemiology: a scientific foundation for using genetic information to improve health and prevent disease. Oxford University Press, New York, pp 127–144
Google Scholar
Gelernter J, Goldman D, Risch N (1993) The A1 allele at the D2 dopamine receptor gene and alcoholism: a reappraisal. J Am Med Assoc 269:1673–1677
CAS
Article
Google Scholar
Genomics Health and Society Working Group (2004) Genomics, Health and Society. Emerging Issues for Public Policy. Government of Canada Policy Research Initiative, Ottawa
Google Scholar
Gluud LL (2006) Bias in clinical intervention research. Am J Epidemiol 163:493–501
PubMed
Article
Google Scholar
Greenspan G, Geiger D (2004) Model-based inference of haplotype block variation. J Comput Biol 11:493–504
PubMed
Article
CAS
Google Scholar
Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafnar T, Gudbjartsson D, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S, Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kimber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC, Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben KK, Graif T, Cashy J, Suarez BK, van Vierssen Trip O, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K (2007) Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet 39:977–983
PubMed
CAS
Article
Google Scholar
Haiman CA, Le Marchand L, Yamamoto J, Stram DO, Sheng X, Kolonel LN, Wu AH, Reich D, Henderson BE (2007a) A common genetic risk factor for colorectal and prostate cancer. Nat Genet 39:954–956
PubMed
CAS
Article
Google Scholar
Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, Neubauer J, Tandon A, Schirmer C, McDonald GJ, Greenway SC, Stram DO, Le Marchand L, Kolonel LN, Frasco M, Wong D, Pooler LC, Ardlie K, Oakley-Girvan I, Whittemore AS, Cooney KA, John EM, Ingles SA, Altshuler D, Henderson BE, Reich D (2007b) Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 39:638–644
PubMed
CAS
Article
Google Scholar
Hall IP, Blakey JD (2005) Genetic association studies in Thorax. Thorax 60:357–359
PubMed
CAS
Article
Google Scholar
Hardy GH (1908) Mendelian proportions in a mixed population. Science 28:49–50
PubMed
Article
Google Scholar
Hattersley AT, McCarthy MI (2005) What makes a good genetic association study? Lancet 366:1315–1323
PubMed
Article
Google Scholar
Hegele R (2002) SNP judgements and freedom of association. Arterioscler Thromb Vasc Biol 22:1058–1061
PubMed
CAS
Article
Google Scholar
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K (2007) A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316:1491–1493
PubMed
CAS
Article
Google Scholar
Higgins JP, Little J, Ioannidis JP, Bray MS, Manolio TA, Smeeth L, Sterne JA, Anagnostelis B, Butterworth AS, Danesh J, Dezateux C, Gallacher JE, Gwinn M, Lewis SJ, Minelli C, Pharoah PD, Salanti G, Sanderson S, Smith LA, Taioli E, Thompson JR, Thompson SG, Walker N, Zimmern RL, Khoury MJ (2007) Turning the pump handle: evolving methods for integrating the evidence on gene-disease association. Am J Epidemiol 166:863–866
PubMed
Article
Google Scholar
Homer N, Szelinger S, Redman M, Duggan D, Tembe W, Muehling J, Pearson JV, Stephan DA, Nelson SF, Craig DW (2008) Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLoS Genet 4:e1000167
PubMed
Article
CAS
Google Scholar
Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF (2004) Detection of genotyping errors by Hardy–Weinberg equilibrium testing. Eur J Hum Genet 12:395–399
PubMed
CAS
Article
Google Scholar
Huang Q, Fu YX, Boerwinkle E (2003) Comparison of strategies for selecting single nucleotide polymorphisms for case/control association studies. Hum Genet 113:253–257
PubMed
CAS
Article
Google Scholar
Huizinga TW, Pisetsky DS, Kimberly RP (2004) Associations, populations, and the truth: recommendations for genetic association studies in Arthritis & Rheumatism. Arthritis Rheum 50:2066–2071
PubMed
Article
Google Scholar
Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover RN, Thomas G, Chanock SJ (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39:870–874
PubMed
CAS
Article
Google Scholar
International HapMap Consortium, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W, Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, Zhao H, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A, Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC, Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z, Huang W, Chu X, He Y, Jin L, Liu Y, Shen Y, Sun W, Wang H, Wang Y, Wang Y, Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB, Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F, Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallee C, Verner A, Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T, Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda T, Deloukas P, Bird CP, Delgado M, Dermitzakis ET, Gwilliam R, Hunt S, Morrison J, Powell D, Stranger BE, Whittaker P, Bentley DR, Daly MJ, de Bakker PI, Barrett J, Chretien YR, Maller J, McCarroll S, Patterson N, Pe’er I, Price A, Purcell S, Richter DJ, Sabeti P, Saxena R, Schaffner SF, Sham PC, Varilly P, Altshuler D, Stein LD, Krishnan L, Smith AV, Tello-Ruiz MK, Thorisson GA, Chakravarti A, Chen PE, Cutler DJ, Kashuk CS, Lin S, Abecasis GR, Guan W, Li Y, Munro HM, Qin ZS, Thomas DJ, McVean G, Auton A, Bottolo L, Cardin N, Eyheramendy S, Freeman C, Marchini J, Myers S, Spencer C, Stephens M, Donnelly P, Cardon LR, Clarke G, Evans DM, Morris AP, Weir BS, Tsunoda T, Mullikin JC, Sherry ST, Feolo M, Skol A, Zhang H, Zeng C, Zhao H, Matsuda I, Fukushima Y, Macer DR, Suda E, Rotimi CN, Adebamowo CA, Ajayi I, Aniagwu T, Marshall PA, Nkwodimmah C, Royal CD, Leppert MF, Dixon M, Peiffer A, Qiu R, Kent A, Kato K, Niikawa N, Adewole IF, Knoppers BM, Foster MW, Clayton EW, Watkin J, Gibbs RA, Belmont JW, Muzny D, Nazareth L, Sodergren E, Weinstock GM, Wheeler DA, Yakub I, Gabriel SB, Onofrio RC, Richter DJ, Ziaugra L, Birren BW, Daly MJ, Altshuler D, Wilson RK, Fulton LL, Rogers J, Burton J, Carter NP, Clee CM, Griffiths M, Jones MC, McLay K, Plumb RW, Ross MT, Sims SK, Willey DL, Chen Z, Han H, Kang L, Godbout M, Wallenburg JC, L’Archeveque P, Bellemare G, Saeki K, Wang H, An D, Fu H, Li Q, Wang Z, Wang R, Holden AL, Brooks LD, McEwen JE, Guyer MS, Wang VO, Peterson JL, Shi M, Spiegel J, Sung LM, Zacharia LF, Collins FS, Kennedy K, Jamieson R, Stewart J (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449:851–861
PubMed
CAS
Article
Google Scholar
Ioannidis JP (2007) Non-replication and Inconsistency in the genome-wide association setting. Hum Hered 64:203–213
PubMed
CAS
Article
Google Scholar
Ioannidis JP, Ntzani EE, Trikalinos TA (2004) ‘Racial’ differences in genetic effects for complex diseases. Nat Genet 36:1312–1318
PubMed
CAS
Article
Google Scholar
Ioannidis JP, Bernstein J, Boffetta P, Danesh J, Dolan S, Hartge P, Hunter D, Inskip P, Jarvelin MR, Little J, Maraganore DM, Bishop JA, O’Brien TR, Petersen G, Riboli E, Seminara D, Taioli E, Uitterlinden AG, Vineis P, Winn DM, Salanti G, Higgins JP, Khoury MJ (2005) A network of investigator networks in human genome epidemiology. Am J Epidemiol 162:302–304
PubMed
Article
Google Scholar
Ioannidis JP, Gwinn M, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter DJ, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, O’Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, Taioli E, Timpson N, Uitterlinden AG, Vineis P, Wareham N, Winn DM, Zimmern R, Khoury MJ, Human Genome Epidemiology Network and the Network of Investigator Networks (2006) A road map for efficient and reliable human genome epidemiology. Nat Genet 38:3–5
PubMed
CAS
Article
Google Scholar
Kamatani N, Sekine A, Kitamoto T, Iida A, Saito S, Kogame A, Inoue E, Kawamoto M, Harigari M, Nakamura Y (2004) Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs. Am J Hum Genet 75:190–203
PubMed
CAS
Article
Google Scholar
Ke X, Hunt S, Tapper W, Lawrence R, Stavrides G, Ghori J, Whittaker P, Collins A, Morris AP, Bentley D, Cardon LR, Deloukas P (2004) The impact of SNP density on fine-scale patterns of linkage disequilibrium. Hum Mol Genet 13:577–588
PubMed
CAS
Article
Google Scholar
Khlat M, Cazes MH, Genin E, Guiguet M (2004) Robustness of case–control studies of genetic factors to population stratification: magnitude of bias and type I error. Cancer Epidemiol Biomarkers Prev 13:1660–1664
PubMed
Google Scholar
Khoury MJ, Little J, Burke W (2004) Human genome epidemiology: scope and strategies. In: Khoury MJ, Little J, Burke W (eds) Human genome epidemiology. Oxford University Press, New York, pp 3–16
Google Scholar
Khoury MJ, Little J, Gwinn M, Ioannidis JP (2007) On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Int J Epidemiol 36:439–445
PubMed
Article
Google Scholar
Kimmel G, Shamir R (2005) GERBIL: Genotype resolution and block identification using likelihood. Proc Natl Acad Sci USA 102:158–162
PubMed
CAS
Article
Google Scholar
Kittles RA, Chen W, Panguluri RK, Ahaghotu C, Jackson A, Adebamowo CA, Griffin R, Williams T, Ukoli F, Adams-Campbell L, Kwagyan J, Isaacs W, Freeman V, Dunston GM (2002) CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification? Hum Genet 110:553–560
PubMed
Article
Google Scholar
Knowler WC, Williams RC, Pettitt DJ, Steinberg AG (1988) Gm3, 5, 13, 14 and type 2 diabetes mellitus: an association in American Indians with genetic admixture. Am J Human Genet 43:520–526
CAS
Google Scholar
Lawrence RW, Evans DM, Cardon LR (2005) Prospects and pitfalls in whole genome association studies. Philos Trans R Soc Lond B Biol Sci 360:1589–1595
PubMed
CAS
Article
Google Scholar
Lee W, Bindman J, Ford T, Glozier N, Moran P, Stewart R, Hotopf M (2007) Bias in psychiatric case–control studies: literature survey. Br J Psychiatry 190:204–209
PubMed
Article
Google Scholar
Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, Vermeire S, Dewit O, de Vos M, Dixon A, Demarche B, Gut I, Heath S, Foglio M, Liang L, Laukens D, Mni M, Zelenika D, Van Gossum A, Rutgeerts P, Belaiche J, Lathrop M, Georges M (2007) Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 3:e58
PubMed
Article
CAS
Google Scholar
Lin BK, Clyne M, Walsh M, Gomez O, Yu W, Gwinn M, Khoury MJ (2006) Tracking the epidemiology of human genes in the literature: The HuGE published literature database. Am J Epidemiol 164:1–4
PubMed
Article
Google Scholar
Little J (2004) Reporting and review of human genome epidemiology studies. In: Khoury MJ, Little J, Burke W (eds) Human genome epidemiology: a scientific foundation for using genetic information to improve health and prevent disease. Oxford University Press, New York, pp 168–192
Google Scholar
Little J, Higgins JPT (eds) (2006) The HuGENet™ HuGE Review Handbook, version 1.0. Available at http://www.hugenet.ca. Accessed 28 February 2006
Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth DL, Hanson J, Khoury M, Lau J, O’Brien TR, Rothman N, Stroup D, Taioli E, Thomas D, Vainio H, Wacholder S, Weinberg C (2002) Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 156:300–310
PubMed
Google Scholar
Little J, Khoury MJ, Bradley L, Clyne M, Gwinn M, Lin B, Lindegren ML, Yoon P (2003) The human genome project is complete. How do we develop a handle for the pump? Am J Epidemiol 157:667–673
PubMed
Article
Google Scholar
Lynch M, Ritland K (1999) Estimation of pairwise relatedness with molecular markers. Genetics 152:1753–1766
PubMed
CAS
Google Scholar
Manly K (2005) Reliability of statistical associations between genes and disease. Immunogenetics 57:549–558
PubMed
Article
Google Scholar
Marchini J, Cardon LR, Phillips MS, Donnelly P (2004) The effects of human population structure on large genetic association studies. Nat Genet 36:512–517
PubMed
CAS
Article
Google Scholar
Marchini J, Howie B, Myers S, McVean G, Donnelly P (2007) A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 39:906–913
PubMed
CAS
Article
Google Scholar
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN (2008) Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9:356–369
PubMed
CAS
Article
Google Scholar
McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316:1488–1491
PubMed
CAS
Article
Google Scholar
Millikan RC (2001) Re: population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 93:156–157
PubMed
CAS
Article
Google Scholar
Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia J (2008) How should we use information about HWE in the meta-analyses of genetic association studies? Int J Epidemiol 37:136–146
PubMed
Article
Google Scholar
Mitchell AA, Cutler DJ, Chakravarti A (2003) Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. Am J Hum Genet 72:598–610
PubMed
CAS
Article
Google Scholar
Moher D, Schultz KF, Altman D (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. J Am Med Assoc 285:1987–1991
CAS
Article
Google Scholar
Nature Genetics (1999) Freely associating (editorial). Nat Genet 22:1–2
Article
CAS
Google Scholar
NCI-NHGRI Working Group on Replication in Association Studies, Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS (2007) Replicating genotype–phenotype associations. Nature 447:655–660
PubMed
CAS
Article
Google Scholar
Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC, The Wellcome Trust Case Control Consortium, Cardon L, Mathew CG (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn’s disease susceptibility. Nat Genet 39:830–832
PubMed
CAS
Article
Google Scholar
Pearson TA, Manolio TA (2008) How to interpret a genome-wide association study. J Am Med Assoc 299:1335–1344
CAS
Article
Google Scholar
Peters DL, Barber RC, Flood EM, Garner HR, O’Keefe GE (2003) Methodologic quality and genotyping reproducibility in studies of tumor necrosis factor-308 G→A. A single nucleotide polymorphism and bacterial sepsis: implications for studies of complex traits. Crit Care Med 31:1691–1696
PubMed
CAS
Article
Google Scholar
Pharoah PD, Dunning AM, Ponder BA, Easton DF (2005) The reliable identification of disease–gene associations. Cancer Epidemiol Biomarkers Prev 14:1362
PubMed
Article
Google Scholar
Plagnol V, Cooper JD, Todd JA, Clayton DG (2007) A method to address differential bias in genotyping in large-scale association studies. PLoS Genet 3:e74
PubMed
Article
CAS
Google Scholar
Pocock SJ, Collier TJ, Dandreo KJ, de Stavola BL, Goldman MB, Kalish LA, Kasten LE, McCormack VA (2004) Issues in the reporting of epidemiological studies: a survey of recent practice. Br Med J 329:883
Article
Google Scholar
Pompanon F, Bonin A, Bellemain E, Taberlet P (2005) Genotyping errors: causes, consequences and solutions. Nat Rev Genet 6:847–859
PubMed
CAS
Article
Google Scholar
Qin ZS, Niu T, Liu JS (2002) Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms. Am J Hum Genet 71:1242–1247
PubMed
CAS
Article
Google Scholar
Rebbeck TR, Martinez ME, Sellers TA, Shields PG, Wild CP, Potter JD (2004) Genetic variation and cancer: improving the environment for publication of association studies. Cancer Epidemiol Biomarkers Prev 13:1985–1986
PubMed
Google Scholar
Reid MC, Lachs MS, Feinstein AR (1995) Use of methodological standards in diagnostic test research. Getting better but still not good. J Am Med Assoc 274:645–651
CAS
Article
Google Scholar
Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR (2007) Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39:596–604
PubMed
CAS
Article
Google Scholar
Romero R, Kuivaniemi H, Tromp G, Olson JM (2002) The design, execution, and interpretation of genetic association studies to decipher complex diseases. Am J Obstet Gynecol 187:1299–1312
PubMed
Article
Google Scholar
Rothman N, Stewart WF, Caporaso NE, Hayes RB (1993) Misclassification of genetic susceptibility biomarkers: implications for case–control studies and cross-population comparisons. Cancer Epidemiol Biomarkers Prev 2:299–303
PubMed
CAS
Google Scholar
Saito YA, Talley NJ, de Andrade M, Petersen GM (2006) Case–control genetic association studies in gastrointestinal disease: review and recommendations. Am J Gastroenterol 101:1379–1389
PubMed
CAS
Article
Google Scholar
Salanti G, Amountza G, Ntzani EE, Ioannidis JP (2005) Hardy–Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet 13:840–848
PubMed
CAS
Article
Google Scholar
Scheet P, Stephens M (2006) A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am J Hum Genet 78:629–644
PubMed
CAS
Article
Google Scholar
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341–1345
PubMed
CAS
Article
Google Scholar
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orru M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3:e115
PubMed
Article
CAS
Google Scholar
Servin B, Stephens M (2007) Imputation-based analysis of association studies: candidate regions and quantitative traits. PLoS Genet 3:e114
PubMed
Article
CAS
Google Scholar
Shen H, Liu Y, Liu P, Recker R, Deng H (2005) Nonreplication in genetic studies of complex diseases—lessons learned from studies of osteoporosis and tentative remedies. J Bone Miner Res 20:365–376
PubMed
CAS
Article
Google Scholar
Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K (2001) dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29:308–311
PubMed
CAS
Article
Google Scholar
Shoemaker J, Painter I, Weir BS (1998) A Bayesian characterization of Hardy–Weinberg disequilibrium. Genetics 149:2079–2088
PubMed
CAS
Google Scholar
Slager SL, Schaid DJ (2001) Evaluation of candidate genes in case–control studies: a statistical method to account for related subjects. Am J Hum Genet 68:1457–1462
PubMed
CAS
Article
Google Scholar
Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA, Masson G, Jakobsdottir M, Thorlacius S, Helgason A, Aben KK, Strobbe LJ, Albers-Akkers MT, Swinkels DW, Henderson BE, Kolonel LN, Le Marchand L, Millastre E, Andres R, Godino J, Garcia-Prats MD, Polo E, Tres A, Mouy M, Saemundsdottir J, Backman VM, Gudmundsson L, Kristjansson K, Bergthorsson JT, Kostic J, Frigge ML, Geller F, Gudbjartsson D, Sigurdsson H, Jonsdottir T, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Jonsson T, von Holst S, Werelius B, Margolin S, Lindblom A, Mayordomo JI, Haiman CA, Kiemeney LA, Johannsson OT, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39:865–869
PubMed
CAS
Article
Google Scholar
Steinberg K, Gallagher M (2004) Assessing genotypes in human genome epidemiology studies. In: Khoury MJ, Little J, Burke W (eds) Human genome epidemiology: a scientific foundation for using genetic information to improve health and prevent disease. Oxford University Press, New York, pp 79–91
Google Scholar
Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978–989
PubMed
CAS
Article
Google Scholar
Tan N, Mulley J, Berkovic S (2004) Association studies in epilepsy: “the truth is out there”. Epilepsia 45:1429–1442
PubMed
CAS
Article
Google Scholar
Thomas DC (2006) Are we ready for genome-wide association studies? Cancer Epidemiol Biomarkers Prev 15:595–598
PubMed
Article
Google Scholar
Thomas DC, Witte JS (2002) Point: population stratification: a problem for case–control studies of candidate–gene associations? Cancer Epidemiol Biomarkers Prev 11:505–512
PubMed
Google Scholar
Tobin MD, Sheehan NA, Scurrah KJ, Burton PR (2005) Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med 24:2911–2935
PubMed
Article
Google Scholar
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tirgoviste C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Dunger DB, The Wellcome Trust Case Control Consortium, Wicker LS, Clayton DG (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39:857–864
PubMed
CAS
Article
Google Scholar
Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I, Gorman M, Wood W, Barclay E, Lubbe S, Martin L, Sellick G, Jaeger E, Hubner R, Wild R, Rowan A, Fielding S, Howarth K, the CORGI Consortium, Silver A, Atkin W, Muir K, Logan R, Kerr D, Johnstone E, Sieber O, Gray R, Thomas H, Peto J, Cazier JB, Houlston R (2007) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 39:984–988
PubMed
CAS
Article
Google Scholar
Trikalinos TA, Salanti G, Khoury MJ, Ioannidis JP (2006) Impact of violations and deviations in Hardy–Weinberg equilibrium on postulated gene-disease associations. Am J Epidemiol 163:300–309
PubMed
Article
Google Scholar
Uhlig K, Menon V, Schmid CH (2007) Recommendations for reporting of clinical research studies. Am J Kidney Dis 49:3–7
PubMed
Article
Google Scholar
van Duijn CM, Porta M (2003) Good prospects for genetic and molecular epidemiologic studies in the European Journal of Epidemiology. Eur J Epidemiol 18:285–286
PubMed
Article
Google Scholar
van Hylckama Vlieg A, Sandkuijl LA, Rosendaal FR, Bertina RM, Vos HL (2004) Candidate gene approach in association studies: would the factor V Leiden mutation have been found by this approach? Eur J Hum Genet 12:478–482
PubMed
CAS
Article
Google Scholar
Vandenbroucke JP, von Elm E, Altman DG, Gotzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M, STROBE initiative (2007) Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Ann Intern Med 147:W163–W194
PubMed
Google Scholar
Vitali S, Randolph A (2005) Assessing the quality of case–control association studies on the genetic basis of sepsis. Pediatr Crit Care Med 6:S74–S77
PubMed
Article
Google Scholar
Voight BF, Pritchard JK (2005) Confounding from cryptic relatedness in case–control association studies. PLoS Genet 1:e32
PubMed
Article
CAS
Google Scholar
von Elm E, Egger M (2004) The scandal of poor epidemiological research. Br Med J 329:868–869
Article
Google Scholar
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, for the STROBE Initiative (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies. PLoS Med 4:e296
Article
Google Scholar
Wacholder S (2005) Publication environment and broad investigation of the genome. Cancer Epidemiol Biomarkers Prev 14:1361
PubMed
Article
Google Scholar
Wacholder S, Rothman N, Caporaso N (2000) Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 92:1151–1158
PubMed
CAS
Article
Google Scholar
Wacholder S, Chatterjee N, Hartge P (2002) Joint effects of genes and environment distorted by selection biases: implications for hospital-based case–control studies. Cancer Epidemiol Biomarkers Prev 11:885–889
PubMed
Google Scholar
Wain HM, Bruford EA, Lovering RC, Lush MJ, Wright MW, Povey S (2002a) Guidelines for human gene nomenclature. Genomics 79:464–470
PubMed
CAS
Article
Google Scholar
Wain HM, Lush M, Ducluzeau F, Povey S (2002b) Genew: the human gene nomenclature database. Nucleic Acids Res 30:169–171
PubMed
CAS
Article
Google Scholar
Wang Y, Localio R, Rebbeck TR (2004) Evaluating bias due to population stratification in case–control association studies of admixed populations. Genet Epidemiol 27:14–20
PubMed
Article
Google Scholar
Wedzicha JA, Hall IP (2005) Publishing genetic association studies in Thorax. Thorax 60:357
Article
Google Scholar
Weinberg W (1908) Über den Nachweis der Vererbung beim Menschen. Jahrhefte Des Vereines Für Vaterländische Naturkunde in Württemberg 64:368–382
Google Scholar
Weiss S (2001) Association studies in asthma genetics. Am J Resp Crit Care Med 164:2014–2015
PubMed
CAS
Google Scholar
Weiss ST, Silverman EK, Palmer LJ (2001) Case–control association studies in pharmacogenetics. Pharmacogenomics J 1:157–158
PubMed
CAS
Google Scholar
Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661–678
Article
CAS
Google Scholar
Whittemore AS (2005) Genetic association studies: time for a new paradigm? Cancer Epidemiol Biomarkers Prev 14:1359–1360
PubMed
Article
Google Scholar
Winker MA (2006) Race and ethnicity in medical research: requirements meet reality. J Law Med Ethics 34:520–525 480
PubMed
Article
Google Scholar
Wong MY, Day NE, Luan JA, Wareham NJ (2004) Estimation of magnitude in gene-environment interactions in the presence of measurement error. Stat Med 23:987–998
PubMed
CAS
Article
Google Scholar
Xu J, Turner A, Little J, Bleecker ER, Meyers DA (2002) Positive results in association studies are associated with departure from Hardy–Weinberg equilibrium: hint for genotyping error? Hum Genet 111:573–574
PubMed
Article
Google Scholar
Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Gelmann EP, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hunter DJ, Chanock SJ, Thomas G (2007) Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 39:645–649
PubMed
CAS
Article
Google Scholar
Yesupriya A, Evangelou E, Kavvoura FK, Patsopoulos NA, Clyne M, Walsh M, Lin BK, Yu W, Gwinn M, Ioannidis JPA, Khoury MJ (2008) Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment. BMC Med Res Methodol 8:31
PubMed
Article
Google Scholar
Yu Y, Yesupriya A, Clyne M, Wulf A, Gwinn M, Khoury MJ (2008) HuGE Literature Finder. HuGE Navigator. Available at http://www.hugenavigator.net/HuGENavigator/searchSummary.do?firstQuery=Gene-disease+association&publitSearchType=now&whichContinue=firststart&check=n&dbType=publit&Mysubmit=go. Accessed 15 December 2008
Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O’shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous ME, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti-Pellie C, Buecher B, Riboli E, Kury S, Chanock SJ, Potter J, Thomas G, Gallinger S, Hudson TJ, Dunlop MG (2007) Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 39:989–994
PubMed
CAS
Article
Google Scholar
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336–1341
PubMed
CAS
Article
Google Scholar
Zerhouni EA, Nabel EG (2008) Protecting aggregate genomic data. Science 322:44
PubMed
CAS
Article
Google Scholar
Zhang W, Collins A, Morton NE (2004) Does haplotype diversity predict power for association mapping of disease susceptibility? Hum Genet 115:157–164
PubMed
Article
Google Scholar
Zhao LP, Li SS, Khalid N (2003) A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case–control studies. Am J Hum Genet 72:1231–1250
PubMed
CAS
Article
Google Scholar
Zou GY, Donner A (2006) The merits of testing Hardy–Weinberg equilibrium in the analysis of unmatched case–control data: a cautionary note. Ann Hum Genet 70:923–933
PubMed
CAS
Article
Google Scholar