Abstract
When mice previously cured of a Plasmodium vinckei infection were subsequently infected with Salmonella enteritidis the course of bacterial infection was significantly retarded, showing increased survival duration as compared with control infections in naive mice. Moreover, on stimulation with lipopolysaccharide and/or interferon-gamma, spleen cells from malaria-cured mice showed an increased capacity to produce tumor necrosis factor, interleukin 6, and reactive nitrogen intermediates as compared with spleen cells from naive mice. However, no significant variation in the capacitiy of spleen cells to release reactive oxygen intermediates was observed between previously malarious and naive mice. The most significant increases were observed in the capacity for reactive nitrogen intermediate production after P. vinckei malaria. These results suggest that the observed protection of mice against salmonellosis in the convalescent phase after malaria may be mediated by nitric oxides.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 8 April 1997 / Accepted: 15 June 1997
Rights and permissions
About this article
Cite this article
Lehman, L., Prada, J. & Kremsner, P. Protection of mice previously infected with Plasmodium vinckei against subsequent Salmonella enteritidis infection is associated with nitric oxide production capacity. Parasitol Res 84, 63–68 (1997). https://doi.org/10.1007/s004360050358
Issue Date:
DOI: https://doi.org/10.1007/s004360050358