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Canine visceral leishmaniosis: the relationship of blood serum thyroid hormones, lipids, and lipoproteins with clinical status

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Abstract

The objective of the present study was to investigate the role of thyroid hormones and lipid profile in development and outcome of canine visceral leishmaniosis (CVL). We therefore studied the relationships between blood serum thyroid hormones [total T4, free T4, total T3, and free T3], lipids, and lipoproteins [total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] and clinical status in dogs naturally infected with Leishmania infantum. Two groups of Leishmania-infected dogs [with no clinical signs (NCS; n = 15), and with clinical signs (CS; n = 16)] were assessed and compared with a group of healthy control dogs (n = 15). A significant decrease in serum total T4 (p < 0.05) concentration in the CS group was observed when compared to the NCS and control groups. The dogs in CS group revealed a significant decrease (p < 0.05) in free T4 concentration in comparison to the control group. The CS group presented a significant decrease in HDL-C (p < 0.01) concentrations, when compared to NCS and control groups. The observed findings in the present study suggested that thyroid hormone and lipoprotein alterations may have a role in susceptibility of dogs with Leishmania infection.

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Acknowledgements

The authors wish to thank technicians who kindly helped us for sample collection of this study.

Funding

This study was supported by a research fund of Ferdowsi University of Mashhad.

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Authors and Affiliations

  1. Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, PO Box 91775-1793, Mashhad, Iran

    M. Khaleghi Einakchi, N. Sedaghat Sharifi, J. Khoshnegah & M. Heidarpour

Authors
  1. M. Khaleghi Einakchi
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  2. N. Sedaghat Sharifi
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  3. J. Khoshnegah
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  4. M. Heidarpour
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Corresponding author

Correspondence to M. Heidarpour.

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This study was approved by the ethics committee of the School of the Ferdowsi University of Mashhad.

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The authors declare that there is no conflict of interest.

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Section Editor: Domenico Otranto

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Khaleghi Einakchi, M., Sedaghat Sharifi, N., Khoshnegah, J. et al. Canine visceral leishmaniosis: the relationship of blood serum thyroid hormones, lipids, and lipoproteins with clinical status. Parasitol Res 117, 3761–3765 (2018). https://doi.org/10.1007/s00436-018-6076-3

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  • DOI: https://doi.org/10.1007/s00436-018-6076-3

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