Skip to main content

Advertisement

Log in

Haemato-biochemical and thyroxin status in Trypanosoma evansi infected dogs

  • Original Article
  • Published:
Journal of Parasitic Diseases Aims and scope Submit manuscript

Abstract

In one year period of study, dogs with inappetence, fever, ocular discharges, dullness, enlarged lymph nodes were screened for the presence of haemoprotozoans at College Hospital of College of Veterinary Science, Tirupati. Wet blood film examination and stained blood smear examination was done to confirm the condition. Peripheral blood smears of dogs revealed the presence of Trypansomes. Trypanosoma evansi was confirmed based on the morphology and measurements of the organisms in the stained blood smears.  Haematology revealed decreased total erythrocyte count, packed cell volume, haemoglobin and total leucocyte count values. Total serum proteins, albumin and glucose levels were decreased significantly (P < 0.01), but a significant increase (P < 0.01) in cholesterol, blood urea nitrogen, serum alkaline phosphatase, serum aspartate aminotransferase and serum alanine aminotransferase levels were observed. Decreased total T4 and free T4 were also observed in the T. evansi infected dogs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Abebe G, Eley RM (1992) Trypanosome–induced hypothyroidism in cattle. Br Vet J 148:63–70 Mutayoba BM, HB Ohara–Ireri and S Gombe

    Article  CAS  PubMed  Google Scholar 

  • Abenga S, Anosa VO (2007) Serum biochemical changes in experimental gambian trypanosomiasis II. Assessing hepatic and renal dysfunction. Turk J Vet Anim Sci 31(5):293–296

    CAS  Google Scholar 

  • Adejinmi JO, Akinboade OA (2000) Serum biochemical changes in WAD goats with experimental mixed T. brucei and Cowdria ruminantum infections. Trop Vet 18(1–2):111–120

    Google Scholar 

  • Allam L, Ogwu D, Agbede RIS, Sackey AKB (2011) Hematological and serum biochemical changes in gilts experimentally infected with Trypanosoma brucei. Vet Arch 81:597–609

    CAS  Google Scholar 

  • Anosa VO (1988) Haematological and biochemical changes in human and animal trypanosomiasis. Part II. Rev Elev Med Vet Pays Trop 41:151–164

    CAS  PubMed  Google Scholar 

  • Bartalena L, Bogazzi F, Brogioni S, Grasso L, Martino E (1998) Role of cytokines in the pathogenesis of the euthyroid sick syndrome. Eur J Endocrinol 138:603–614

    Article  CAS  PubMed  Google Scholar 

  • Cadioli FA, Marqus LC, Machado RZ, Alessi AC, Aquino LPCT, Barnabe PA (2006) Experimental Trypanosoma evansi infection in donkeys: hematological, biochemical and histopathological changes. Arq Bras Med Vet Zootec 58:749–756

    Article  CAS  Google Scholar 

  • De Menezes VT, Queiroz AO, Gomes MA, Marques MA, Jansen AM (2004) Trypanosoma evansi in inbred and Swiss-Webster mice: distinct aspects of pathogenesis. Parasitol Res 94:193–200

    Article  PubMed  Google Scholar 

  • Gunaseelan L, Kumar KS, Selvaraj P, Kathiresan D (2009) Haemato biochemical changes in a case of canine trypanosomiasis. Tamilnadu J Vet Anim Sci 5(3):122–123

    Google Scholar 

  • Gutierrez C, Corbera JA, Juste MC, Doreste F, Morales I (2005) An outbreak of abortions and high neonatal mortality associated with Trypanosoma evansi infection in dromedary camels in the Canary Islands. Vet Parasitol 130(1):163–168

    Article  CAS  PubMed  Google Scholar 

  • Kahl S, Elsasser TH, Sartin JL, Fayer R (2002) Effect of progressive cachectic parasitism and growth hormone treatment on hepatic 5′–deiodinase activity in calves. Domest Anim Endocrinol 22:211–221

    Article  CAS  PubMed  Google Scholar 

  • Kjos SA, Snowden KF, Craig TW, Lewis B, Ronald N, Olson JK (2008) Distribution and characterization of canine chagas disease in texas. Vet Parasitol 152:249–256

    Article  CAS  PubMed  Google Scholar 

  • Mutayoba BM, Ohara-Ireri HB, Gombe S (1988) Trypanosome–induced depression of plasma thyroxine levels in prepubertal and adult female goats. Acta Endocrinol (Cph) 119:21–26

    CAS  Google Scholar 

  • O.I.E., (2008) Trypanosoma evansi infections (including surra) In: OIE terrestrial manual 2008. Office International des Epizooties World Health Organization for Animal Health, Paris. Pp: 352–360

  • Orhue NEJ, Nwanze EAC, Akafor A (2005) Serum total protein, albumin and globulin levels in Trypanosoma brucei–infected rabbits: effect of orally administered scoparia dulcis. Afr J Biotechnol 4:1152–1155

    Google Scholar 

  • Reddy BS, Kumari KN, Sivajothi S (2014) Haemato-biochemical findings and thyroxin levels in canine demodicosis. Comp Clin Pathol. doi:10.1007/s00580-014-1893-y

    Google Scholar 

  • Sazmand A, Rasooli A, Nouri M, Hamidinejat H, Hekmatimoghaddam S (2011) Serobiochemical alterations in subclinically affected dromedary camels with Trypanosoma evansi in Iran. Pak Vet J 31(3):223–226

    CAS  Google Scholar 

  • Sivajothi S, Rayulu VC, Reddy BS (2012) Development of slide enzyme linked immunosorbent assay (SELISA) for detection of Trypanosoma evansi infection in bovines. J Adv Vet Res 2:15–17

    Google Scholar 

  • Sivajothi S, Rayulu VC, Malakondaiah P, Sreenivasulu D (2013a) Colloidal dye immunobinding assay for detection of Trypanosoma evansi antibodies in animals. Int J of Livest Res 3(3):48–56

    Article  Google Scholar 

  • Sivajothi S, Rayulu VC, Reddy BS (2013b) Haematological and biochemical changes in experimental Trypanosoma evansi infection in rabbits. J Parasit Dis. doi:10.1007/s12639-013-0321-6

    Google Scholar 

  • Sivajothi S, Rayulu VC, Malakondaiah P, Sreenivasulu D (2014a) Diagnosis of Trypanosoma evansi in bovines by indirect ELISA. DOI, J Parasit Dis. doi:10.1007/s12639-014-0465-z

    Google Scholar 

  • Sivajothi S, Rayulu VC, Reddy BS (2014b) Detection of Trypanosoma evansi by different methods in bovines in Andhra Pradesh. J. Adv. Parasitol 1(3):35–38.

  • Sivajothi S, Reddy BS, Kumari KN, Rayulu VC (2014c) Haematological changes in Trypanosoma evansi infected cattle. Int J of Sci World 2(1):27–30

    Google Scholar 

  • Soulsby EJL (1982) Helminths, arthropods and protozoa of domesticated animals, 7th Ed. Elsevier, a division of Reed Elsevier India Pvt. Ltd., New Delhi pp:533

  • Sulaiman FA, Adeyemi OS (2010) Changes in haematological indices and protein concentrations in Trypansoma brucei infected rats treated with homidium chloride and diminazene aceturate. EXCLI J 9:39–45

    Google Scholar 

  • Taiwo VO, Olaniyi MO, Ogunsanmi AO (2003) Comparative plasma biochemical changes and susceptibility of erythrocytes to in vitro peroxidation during experimental Trypanosoma congolense and Trypanosoma brucei infection in sheep. Israel J Vet Med 58(4):112–117

    Google Scholar 

  • Takeet M, Fagbemi BO (2009) Haematological, pathological and plasma biochemical changes in rabbits experimentally infected with Trypanosoma congolense. Sci World J 4(2):29–36

    Google Scholar 

Download references

Acknowledgments

The authors acknowledge the authorities of Sri Venkateswara Veterinary University, Tirupati for providing facilities to carry out this research. Corresponding author was also thankful to the Drs. Venkata Reddy, Khadir Basha, Vaani who helped in collection of blood samples.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B. Sudhakara Reddy.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Reddy, B.S., Kumari, K.N., Sivajothi, S. et al. Haemato-biochemical and thyroxin status in Trypanosoma evansi infected dogs. J Parasit Dis 40, 491–495 (2016). https://doi.org/10.1007/s12639-014-0531-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12639-014-0531-6

Keywords

Navigation