Abstract
Objective
Double primary cervical cancer and ovarian cancer refer to the simultaneous or successive appearance of cervical cancer and ovarian cancer in the same patient. Due to the low incidence, there are few relevant reports. Therefore, this study is the first population-based analysis of the clinicopathological features as well as the prognostic status of double primary cervical cancer and ovarian cancer. We look forward to providing a reference for future clinical diagnosis and treatment.
Methods
In this study, 473 cases of double primary cervical cancer and ovarian cancer were collected from 1975 to 2019 through the SEER database. Double primary cancers were considered non-synchronous when they were diagnosed more than 6 months apart and were classified as Group A. Double primary cancers were considered synchronous when the interval between diagnosis of the two tumors was less than or equal to 6 months and was classified as group B.
Results
In this study, the incidence of double primary cervical cancer and ovarian cancer accounted for 0.39% of primary cervical cancer and 0.24% of primary ovarian cancer in the same period. 80% of patients developed second cancer within 107 months of their first cancer being diagnosed. Compared with non-synchronous cancer, synchronous cancer is mainly characterized by simultaneous bilateral ovarian involvement and early clinical stage, but highly malignant, high lymph node metastasis rate, and poor prognosis.
Conclusion
Most patients developed second cancer within 107 months of their first cancer being diagnosed. Age at diagnosis, bilateral ovarian invasion, the interval between diagnoses, pathological type and stage of ovarian cancer, and grade of cervical cancer are important factors affecting survival, which still needs to be confirmed by more extensive studies in future.
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Data availability
The data that support the findings of this study are available from the corresponding author, upon reasonable request.
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YH was involved in protocol development, data analysis, manuscript writing and editing. XW contributed to data collection. XL, JC were involved in data analysis. LO contributed to data analysis and manuscript editing. YL was involved in protocol development, literature screening, and manuscript editing.
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Han, Y., Wang, X., Li, X. et al. Analysis of clinicopathological features and prognosis of double primary cervical cancer and ovarian cancer based on SEER database. J Cancer Res Clin Oncol 149, 16407–16415 (2023). https://doi.org/10.1007/s00432-023-05373-y
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DOI: https://doi.org/10.1007/s00432-023-05373-y