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Anticancer acumens of three Annona species: a proportional review

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Abstract

Introduction

Cumulative pattern of cancer could be seen in day-to-day life with each passing year and, it is becoming a great matter of concern especially to the scientific community worldwide. Alternative treatment methods for various types of cancer are in place and, being continuously worked out. Plant-derived natural substances have shown great results in combating cancer in comparison to chemo and radiotherapies which are toxic besides having serious side effects. In continuation, Annona species, native to America, Africa, Asia and Australia have been used in folk medicines and, are reported to have many anti-carcinogenic substances.

Methods

For a prudent understanding of Annona species against various cancers, comparative investigation and analysis of three species viz., A. cherimola, A. muricata, and A. squamosa was undertaken through a detailed review of the in-attendance subject. The major scientific biomedical literature databases were consulted and the information available from 2011 until January 2021 was taken into account.

Results

Studies on anti-cancer activities along with the thorough analysis of the findings and the pieces of evidence supporting their anti-proliferative, apoptosis, G1 cell cycle arrest and cytotoxic effects are described. A. muricata displayed maximum number of anti-cancer activities being revealed by most of its parts with the lowest IC50 values against various cancer cell lines compared to A. cherimola and A. squamosa. On account of the findings, it is advocated that, further detailed studies on anti-cancer explorations of Annona species could be proved fruitful in paving new and innovative methodologies for novel anti-cancer drug discovery and development.

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Fig. 1

Source: Patanjali Botanical Paintings Section

Fig. 2

Source: Patanjali Botanical Paintings Section

Fig. 3

Source: Rady et al. (2018)

Fig. 4

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Data availability

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Acknowledgements

The authors all like to convey their sincere appreciation to Revered Swami Ramdev for his unflagging support and direction. We also appreciate the prompt administrative help from Mr. Lalit Mohan and Mr. Gagan Kumar, as well as the graphic support from Mr. Sunil Kumar.

Funding

This study has been conducted using internal research funds from Patanjali Research Foundation Trust, Haridwar, Uttarakhand, India. This work received no other specific external funding or grant from any funding agency.

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Authors and Affiliations

  1. Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar, Uttarakhand, 249405, India

    Acharya Balkrishna, Neelam R. Dabhade, Ashwini Singh & Vedpriya Arya

  2. University of Patanjali, Patanjali Yogpeeth, Haridwar, Uttarakhand, 249405, India

    Acharya Balkrishna & Vedpriya Arya

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  1. Acharya Balkrishna
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Contributions

AB: Conceptualization, Funding acquisition, Resources. Dr. NRD: Visualization, Data curation, Formal analysis, Writing- Original draft, Validation, Editing. Dr. AS: Reviewing original draft and incorporation of pharmacological database. Dr. VA: Project administration, Supervision, Guidance, Suggestive measures and Final correction.

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Correspondence to Neelam R. Dabhade.

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Balkrishna, A., Dabhade, N.R., Singh, A. et al. Anticancer acumens of three Annona species: a proportional review. J Cancer Res Clin Oncol 149, 6693–6702 (2023). https://doi.org/10.1007/s00432-022-04306-5

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