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Prognostic significance of tumor poliovirus receptor and CTLA4 expression in patients with surgically resected non-small-cell lung cancer

  • Original Article – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Introduction

Poliovirus receptor (PVR) is a tumor promoter and a regulatory checkpoint that enhances immunosuppression. We investigated PVR expression by applying immunohistochemistry (IHC) staining. A positive association existed between PVR expression and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) expression in patients with surgically resected non-small-cell lung cancer (NSCLC). PVR expression is a prognosis predictor of lung adenocarcinoma.

Purpose

To investigate the prognostic significance of PVR expression and CTLA4 expression for surgically resected NSCLC.

Patients and methods

The medical records of 108 Chinese patients with primary NSCLC who underwent surgery were retrospectively reviewed. The expression of PVR and CTLA4 were measured through IHC. Clinical characteristics, the association between PVR and CTLA4, and the prognostic significance of PVR were analyzed.

Results

A significant positive association was observed between PVR and CTLA4 expression in NSCLC (P = 0.016). PVR had a high positive rate among females, nonsmokers, and patients with adenocarcinoma and advanced lung cancer. The overall survival (OS) of patients with negative PVR expression was significantly longer than that of patients with positive PVR expression (P = 0.049), especially among females (P = 0.03) and nonsmokers (P = 0.025). Multivariate analysis results showed that advanced tumor stage and PVR expression were independent prognosis predictors of poor OS.

Conclusion

PVR can potentially serve as a prognostic predictor and biomarker for NSCLC and cancer anti-CTLA4 immunotherapy response.

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Funding

This work was funded by Taihe Hospital with internal funding and the Science and Technology Development Fund, Macau SAR (0096/2018/A3, 130/2017/A3, and 0099/2018/A3).

Author information

Author notes

  1. Hui You, Yi-Zhong Zhang and Huan-Ling Lai contributed equally.

Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China

    Hui You, Yu-Quan Liu & Mei-Fang Wang

  2. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China

    Yi-Zhong Zhang, Huan-Ling Lai, Run-Ze Li, Imran Khan, Wendy Wen-Lun Hsiao, Fu-Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Qi-Biao Wu & Elaine Lai-Han Leung

  3. Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China

    Dan Li

  4. Department of Oncology, Kiang Wu Hospital, Macau (SAR), China

    Ya-Bing Cao

  5. Hubei Key Laboratory of Embryonic Stem Cell Research, Shiyan, China

    Mei-Fang Wang

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  1. Hui You
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Contributions

MFW, ELHL, and QBW conceived the research and led the project. MFW, ELHL, QBW, HLL, and YZZ wrote the manuscript. MFW, YBC, HWWL, ELHL, and HLL revised and finalized the manuscript. YH, YZZ, HLL, LD, LYQ, RZL, IK, FGD, FXX, and XJY carried out the experiments and analyzed the data. All authors reviewed the manuscript.

Corresponding authors

Correspondence to Qi-Biao Wu, Elaine Lai-Han Leung or Mei-Fang Wang.

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The authors declare no conflict of interests.

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All procedures in studies involving human participants were performed in accordance with the ethical standards and approved by the ethics committee of Hubei Taihe Hospital.

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You, H., Zhang, YZ., Lai, HL. et al. Prognostic significance of tumor poliovirus receptor and CTLA4 expression in patients with surgically resected non-small-cell lung cancer. J Cancer Res Clin Oncol 146, 1441–1450 (2020). https://doi.org/10.1007/s00432-020-03189-8

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  • DOI: https://doi.org/10.1007/s00432-020-03189-8

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