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Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population

  • Original Article – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Two genome-wide association studies (GWASs) have identified several new acute leukemia susceptibility loci in populations of European descent. However, the roles of these loci in the development of acute leukemia in other populations are largely unknown.

Methods

We genotyped 16 single-nucleotide polymorphisms selected from published GWASs in an independent case–control study with a total of 545 acute myeloid leukemia (AML) cases and 1034 cancer-free controls in a Chinese population. Multivariate logistic regression was used to analyze the associations between these variants and AML risk.

Results

We found that with the similar effect to GWASs, risk alleles of rs2191566, rs9290663, rs11155133, rs2239633, rs10821936, and rs2242041 significantly increased the risk of AML in at least one genetic model [odds ratios (ORs) range from 1.26 to 4.34, P values range from <0.001 to 0.043]. However, the variant T allele of rs10873876 decreased the AML risk, which was in the opposite effect direction (OR 0.62, P < 0.001 in additive model). Besides, we found significant multiplicative interaction between rs9290663 and age (≤45 years old and >45 years old; P = 0.009).

Conclusion

Our results indicated that genetic variants associated with acute leukemia risk in European populations may also play important roles in AML development in Chinese population.

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Acknowledgments

This work is funded by the National Natural Science Foundation for Young Scholars of China (81402739 and 81200361); New Century Excellent Talents in University (NCET-10-0178); and Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine).

Conflict of interest

The authors declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China

      Songyu Cao, Hongxia Ma & Zhibin Hu

    2. Department of Hematology, Wuxi Peoples’s Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi, 214194, China

      Guohua Yang, Juan Zhang, Yunfeng Shen & Xifeng Qian

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    1. Songyu Cao
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    Correspondence to Hongxia Ma.

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    S. Cao and G. Yang have contributed equally to this article.

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    Cao, S., Yang, G., Zhang, J. et al. Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population. J Cancer Res Clin Oncol 142, 149–155 (2016). https://doi.org/10.1007/s00432-015-2010-6

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    • DOI: https://doi.org/10.1007/s00432-015-2010-6

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