Abstract
Purpose
N-acetyltransferase 2 (NAT2) plays an important role in the metabolism of various potential carcinogens, which can be subdivided into rapid and slow acetylation phenotype according to the different genotypes. A number of studies have been devoted to the association of NAT2 polymorphism with susceptibility to laryngeal carcinoma; however, the results were inconsistent and inconclusive. The aim of the present study was to conduct a meta-analysis assessing the possible association of NAT2 polymorphism with laryngeal cancer risk.
Methods
The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure until February 2011 and selected on the basis of the established inclusion criteria for publications, and then a meta-analysis was performed to quantitatively summarize the association of NAT2 polymorphism with laryngeal cancer susceptibility.
Results
Seven studies were included in the present meta-analysis, which described a total of 980 laryngeal cancer cases and 1,487 controls. The overall odds ratio (OR) for NAT2 slow and rapid acetylators was 0.99 (95% CI = 0.71–1.38) and 1.01 (95% CI = 0.72–1.40), respectively. When stratifying for race, the pooled ORs for NAT2 slow acetylator were 1.99 (95% CI = 1.10–3.63) in Asians and 0.85 (95% CI = 0.62–1.15) in Caucasians, and the pooled ORs for NAT2 rapid acetylator were 0.50 (95% CI = 0.28–0.91) in Asians and 1.18 (95% CI = 0.87–1.60) in Caucasians.
Conclusions
This meta-analysis suggested that there was overall lack of association between NAT2 polymorphism and laryngeal cancer risk; however, NAT2 slow acetylation may contribute to a risk factor for laryngeal cancer in Asians but not in Caucasians.
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Abbreviations
- NAT2:
-
N-acetyltransferase 2
- SCC:
-
Squamous cell carcinoma
- OR:
-
Odds ratio
- CI:
-
Confidence interval
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We are indebted to the authors of the primary studies.
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We declare that we have no conflict of interest.
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Ying, XJ., Dong, P., Shen, B. et al. Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis. J Cancer Res Clin Oncol 137, 1661–1667 (2011). https://doi.org/10.1007/s00432-011-1045-6
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DOI: https://doi.org/10.1007/s00432-011-1045-6