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Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

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Abstract

Purpose and methods

Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.

Results

Three regions were detected to have a high LOH rate which included 14q21.2-22.3 (42.5%), 14q31 (55%), and 14q32.1 (37%). The correlation between LOH and clinicopathological findings was investigated through statistical analyses. A strong correlation was observed between the highest LOH marker and the overall and disease-free survival.

Conclusions

The results suggest that the distal part of chromosome 14 may host a TSG that may lead to the development and/or progression of HNSCCs. Several genes such as CHES1, BMP4, SAV, and PNN have arisen as candidate tumor suppressors in the region.

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Acknowledgments

This work was partially supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology [19592109 (to HN), 18-06262 (to EG), 17406027 (to NN)], Seed Innovation Research from Japan Science and Technology Agency (to MG), from Sumitomo Trust Haraguchi Memorial Cancer Research Promotion (to MG) and Astrazeneca Research Grant (to MG).

Conflict of interest statement

None of the authors has any potential conflict of interest.

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Authors and Affiliations

  1. Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikatacho 2-5-1, Okayama, 700-8525, Japan

    Davut Pehlivan, Esra Gunduz, Mehmet Gunduz, Hitoshi Nagatsuka, Beyhan Cengiz & Rosario S. Rivera

  2. Department of Otolaryngology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikatacho 2-5-1, Okayama, Japan

    Kunihiro Fukushima

  3. Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Shikatacho 2-5-1, Okayama, Japan

    Esra Gunduz & Kenji Shimizu

  4. Department of Otolaryngology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan

    Mehmet Gunduz, Levent Bekir Beder & Noboru Yamanaka

  5. Department of Medical Genetics, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Davut Pehlivan, Sukru Palanduz & Sukru Ozturk

Authors
  1. Davut Pehlivan
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  2. Esra Gunduz
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  3. Mehmet Gunduz
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  4. Hitoshi Nagatsuka
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  11. Noboru Yamanaka
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Corresponding author

Correspondence to Mehmet Gunduz.

Additional information

Davut Pehlivan and Esra Gunduz contributed equally to this work.

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Pehlivan, D., Gunduz, E., Gunduz, M. et al. Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. J Cancer Res Clin Oncol 134, 1267–1276 (2008). https://doi.org/10.1007/s00432-008-0423-1

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  • DOI: https://doi.org/10.1007/s00432-008-0423-1

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