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Frequent chromosomal aberrations and candidate genes in head and neck squamous cell carcinoma

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Abstract

The knowledge of the biology of head and neck squamous cell carcinoma (HNSCC) has had relatively little impact on the improvement in oncologic outcome up to date. However, the identification of oncogenes and tumor suppressor genes (TSGs) involved in cancer progression contributes to the understanding of the molecular pathways involved in oncogenesis and could contribute to individual risk assessment and provide tools for improvement of treatment and targets for therapy based on the alterations in these pathways. The aim of this article is to review the chromosomal aberrations commonly found in HNSCC, to identify the genes in these chromosomal regions suggested to act as (candidate) oncogenes or TSGs, and to discuss the molecular mechanisms modulating their expression.

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Authors and Affiliations

  1. Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    Krzysztof Szyfter

  2. Department of Otolaryngology and Laryngeal Oncology, K. Marcinkowski University of Medical Sciences, Poznan, Poland

    Malgorzata Wierzbicka

  3. Department of Pathology and Laboratory Services, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Jennifer L. Hunt

  4. University of Udine School of Medicine, Udine, Italy

    Alessandra Rinaldo & Alfio Ferlito

  5. Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Juan P. Rodrigo

  6. Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain

    Juan P. Rodrigo

  7. Department of Otolaryngology Head and Neck Surgery, Radboud University Medicine Center, Nijmegen, The Netherlands

    Robert P. Takes

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  1. Krzysztof Szyfter
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  2. Malgorzata Wierzbicka
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  3. Jennifer L. Hunt
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  4. Alessandra Rinaldo
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  7. Alfio Ferlito
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Correspondence to Alfio Ferlito.

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This paper was written by members of the International Head and Neck Scientific Group (http://www.IHNSG.com).

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Szyfter, K., Wierzbicka, M., Hunt, J.L. et al. Frequent chromosomal aberrations and candidate genes in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 273, 537–545 (2016). https://doi.org/10.1007/s00405-014-3339-1

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