Skip to main content
Log in

Epididymal cyst in children

  • Review
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

The terms “epididymal cyst” and “spermatocele” are commonly used to describe the same entity, but, conversely, they are slightly different. Epididymal cyst is a benign mass, and it is more common than previously thought in prepubertal age. Pathogenic mechanisms for epididymal cyst have not been fully clarified yet, even if epididymal cysts have been reported in association with other malformations of the urinary tract or complex syndromes. Epididymal cyst is easily characterized and differentiated from spermatocele using ultrasound imaging. Conservative management constitutes the treatment of choice in the majority of cases, and surgery is recommended only in selected cases.

Conclusion: To date, a review on epididymal cyst in childhood is lacking in the literature. Herein, an overview of knowledge about epididymal cyst in children has been carried out with particular attention to differential diagnosis, proper management, and practice guidelines for caregivers of children who may present with an epididymal cyst.

What is Known:

Epididymal cyst is a benign sac in the testicles which is usually asymptomatic.

Epididymal cyst is easily diagnosed by ultrasound scans, and it is considered a self-limiting disease in the majority of cases.

What is New:

Insight on differential diagnosis between epididymal cyst and spermatocele.

Valuable knowledge on the best management strategy for epididymal cyst and on practice guidelines for parents of children presenting with epididymal cyst.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Data Availability

N/A

Code availability

N/A

References

  1. O'Kelly F, McAlpine K, Abdeen N, Keays MA, Guerra LA, Leonard MP (2019) The futility of continued surveillance of epididymal cysts - a study of the prevalence and clinico-demographics in pre- vs. post-pubertal boys. Can Urol Assoc J 13(12):E398–E403

    Article  Google Scholar 

  2. Munden MM, Trautwein LM (2000) Scrotal pathology in pediatrics with sonographic imaging. Curr Probl Diagn Radiol 29:185

    Article  CAS  Google Scholar 

  3. Cooper TG, Raczek S, Yeung CH, Schwab E, Schulze H, Hertle L (1992) Composition of fluids obtained from human epididymal cysts. Urol Res 20:275–280

    Article  CAS  Google Scholar 

  4. Erikci V, Hoşgör M, Aksoy N, Okur Ö, Yildiz M, Dursun A, Demircan Y, Örnek Y, Genişol İ (2013) Management of epididymal cysts in childhood. J Pediatr Surg 48(10):2153–2156

    Article  Google Scholar 

  5. Jones RE, Lopez KH (2014) Chapter 4 - The male reproductive system. In: Jones RE, Lopez KH (eds) Human reproductive biology, Fourth edn. Academic Press, pp 67–83, ISBN 9780123821843. https://doi.org/10.1016/B978-0-12-382184-3.00004-0

  6. Casey RG, Stunell H, Buckley O, Flynn R, Torreggiani WC (2008) A unique radiological pentad of mesonephric duct abnormalities in a young man presenting with testicular swelling. Br J Radiol 81(963):e93–e96. https://doi.org/10.1259/bjr/31182823

    Article  CAS  PubMed  Google Scholar 

  7. Cosentino MJ, Cockett AT (1986) Structure and function of the epididymis. Urol Res 14:229

    Article  CAS  Google Scholar 

  8. Homayoon K, Suhre CD, Steinhardt GF (2004) Epididymal cysts in children: natural history. J Urol 171(3):1274–1276

    Article  Google Scholar 

  9. Skakkebaek NE (2002) Endocrine disrupters and testicular dysgenesis syndrome. Horm Res 57:43

    CAS  PubMed  Google Scholar 

  10. Marshall FF, Shermeta DW (1979) Epididymal abnormalities associated with undescended testis. J Urol 121:341–343

    Article  CAS  Google Scholar 

  11. Leung ML, Gooding GA, Williams RD (1984) High-resolution sonography of scrotal contents in asymptomatic subjects. AJR Am J Roentgenol 143(1):161–164

    Article  CAS  Google Scholar 

  12. Blau H, Freud E, Mussaffi H, Werner M, Konen O, Rathaus V (2002) Urogenital abnormalities in male children with cystic fibrosis. Arch Dis Child 87(2):135–138

    Article  CAS  Google Scholar 

  13. Belet U, Danaci M, Sarikaya S, Odabaş F, Utaş C, Tokgöz B, Sezer T, Turgut T, Erdoğan N, Akpolat T (2002) Prevalence of epididymal, seminal vesicle, prostate, and testicular cysts in autosomal dominant polycystic kidney disease. Urology. 60(1):138–141

    Article  Google Scholar 

  14. Joerger M, Koeberle D, Neumann HP, Gillessen S (2005) Von Hippel-Lindau disease--a rare disease important to recognize. Onkologie. 28(3):159–163

    PubMed  Google Scholar 

  15. Sheih CP, Hung CS, Wei CF, Lin CY (1990) Cystic dilatations within the pelvis in patients with ipsilateral renal agenesis or dysplasia. J Urol 144:324–327

    Article  CAS  Google Scholar 

  16. Nistal M, González-Peramato P, Sousa G, García-Cabezas MA, Rodríguez JI, Cajaiba MM (2010) Cystic dysplasia of the epididymis: a disorder of mesonephric differentiation associated with renal maldevelopment. Virchows Arch 456(6):695–702

    Article  Google Scholar 

  17. Posey ZQ, Ahn HJ, Junewick J, Chen JJ, Steinhardt GF (2010) Rate and associations of epididymal cysts on pediatric scrotal ultrasound. J Urol 184(4 Suppl):1739–1742

    Article  Google Scholar 

  18. Chung SE, Frush DP, Fordham LA (1999) Sonographic appearances of extratesticular fluid and fluid-containing scrotal masses in infants and children: clues to diagnosis. AJR Am J Roentgenol 173:741–745

    Article  CAS  Google Scholar 

  19. Aragona F, Pescatori E, Talenti E, Tomà P, Malena S, Glazel GP (1996) Painless scrotal masses in the pediatric population: prevalence and age distribution of different pathological conditions--a 10 years retrospective multicenter study. J Urol 155(4):1424–1426

    Article  CAS  Google Scholar 

  20. Annam A, Munden MM, Mehollin-Ray AR, Schady D, Browne LP (2015) Extratesticular masses in children: taking ultrasound beyond paratesticular rhabdomyosarcoma. Pediatr Radiol 45(9):1382–1391

    Article  Google Scholar 

  21. Vick CW 3rd, Klein FA, Schneider V (1991) Adenomatoid tumor of epididymis simulating benign cyst on scrotal ultrasound. Urology 38(4):369–371

    Article  Google Scholar 

  22. Huzaifa M, Moreno MA (2020) Hydrocele. In: StatPearls. StatPearls Publishing, Treasure Island

    Google Scholar 

  23. Erikçi V, Hoşgör M, Yıldız M, Aksoy N, Okur Ö, Örnek Y, Demircan Y (2013) Torsion of an epididymal cyst: a case report and review of the literature. Turk J Pediatr 55(6):659–661

    PubMed  Google Scholar 

  24. Messina M, Fusi G, Ferrara F, Bindi E, Pellegrino C, Molinaro F et al (2019) A rare cause of acute scrotum in a child: torsion of an epididymal cyst. Case report and review of the literature. Pediatr Med Chir 41(1). https://doi.org/10.4081/pmc.2019.210

  25. Tammela TL, Hellström PA, Mattila SI, Ottelin PJ, Malinen LJ, Mäkäräinen HP (1992) Ethanolamine oleate sclerotherapy for hydroceles and spermatoceles: a survey of 158 patients with ultrasound followup. J Urol 147(6):1551–1553

    Article  CAS  Google Scholar 

  26. Sigurdsson T, Johansson JE, Jahnson S, Helgesen F, Andersson SO (1994) Polidocanol sclerotherapy for hydroceles and epididymal cysts. J Urol 151(4):898–901

    Article  CAS  Google Scholar 

  27. Braslis KG, Moss DI (1996) Long-term experience with sclerotherapy for treatment of epididymal cyst and hydrocele. Aust N Z J Surg 66(4):222–224

    Article  CAS  Google Scholar 

  28. Deoreo GA, Jones JS (2006) Adult Scrotal Surgery. In: Novick AC, Jones JS (eds) Operative Urology at Cleveland Clinic. Humana Press, Totowa

    Google Scholar 

  29. Tanrikut C, Sclegel PN (2012) Spermatocelectomy. In: Smith JA Jr, Howards SS, Mc Guire EJ, Preminger GM (eds) Hinman’s Atlas of Urologic Surgery, III edn. Elsevier Saunders, Philadelphia

    Google Scholar 

  30. Rioja J, Sánchez-Margallo FM, Usón J, Rioja LA (2011) Adult hydrocele and spermatocele. BJU Int 107(11):1852–1864

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Sir Massimo Tomadin for his support with the illustrations enclosed in this article and Sir Kevin J.C. Gibson for his help to further improve language quality.

Author information

Authors and Affiliations

Authors

Contributions

Dr. Alessandro Boscarelli conceptualized the study, collected data, and drafted the initial manuscript. Dr. Tommaso Bellini has integrated and reviewed the final manuscript. The authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Alessandro Boscarelli.

Ethics declarations

Ethics approval

N/A

Consent to participate

N/A

Consent for publication

N/A

Competing interests

The authors declare no competing interests.

Additional information

Communicated by Piet Leroy

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boscarelli, A., Bellini, T. Epididymal cyst in children. Eur J Pediatr 180, 2723–2729 (2021). https://doi.org/10.1007/s00431-021-04080-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-021-04080-5

Keywords

Navigation