Neonatal lung ultrasound is a novel imaging technique that is gathering growing interest in neonatal intensive care units (NICU). Functional lung ultrasound is able to document the failure of non-invasive respiratory support that often preludes to exogenous surfactant administration for respiratory distress syndrome (RDS) [1].

The current European guidelines for the administration of surfactant only rely on the need for a certain inspiratory oxygen fraction threshold [2]. This, however, has a weak evidence background mainly coming from a single, small-sized, single-center, retrospective study [3]. Moreover, inspired oxygen fraction (FiO2) cannot give any accurate description of the oxygenation status, as it does not take into consideration many important variables that significantly influence oxygenation, such as the constant distending pressure provided to the patient, arterial oxygen pressure, temperature, peripheral perfusion, hemoglobin concentration, and the extremely variable level of fetal hemoglobin, just to name a few.

Unsurprisingly, the American Academy of Pediatrics guidelines on surfactant replacement do not recommend any FiO2 thresholds to give surfactant and only highlight that surfactant should be given as early as possible in the process of RDS [4]. On the same line, it is not surprising that severe respiratory failure in adults and children [5, 6] is not evaluated by using only FiO2, which is not a criterion for the definition of neonatal, pediatric, or adult ARDS neither [5, 7, 8].

However, there are enough evidence-based data to give surfactant as early as possible (that is, within the first 3 hours of life) [9] in preterm neonates affected by RDS treated with continuous positive airway pressure (CPAP) and all guidelines recognize this [2, 4].

Thus, here we have a substantial problem. We should make a diagnosis of RDS in CPAP-treated preterm neonates and identify those patients who will fail CPAP and need surfactant replacement and those who will not fail CPAP and may spare the treatment. More and above this, we need to do this investigation is a short period (3 hours), which is shorter than it may seem when one is diving into routine neonatal critical care in a very busy NICU.

Complex and important problems in clinical medicine are not likely to have an easy solution. In fact, FiO2 alone misses several oxygenation variables and, because of its inaccuracy, may lead to unnecessary surfactant administration with unwanted consequences (need for sedation, desaturation, etc.) or to delayed surfactant administration and reduced therapeutic efficacy when the need for oxygen rises only late. These are everyday experiences for NICU practitioners.

An utterly innovative strategy is represented by the use of semi-quantitative lung ultrasound which is not evaluating the oxygenation, but it is instead “visualizing” lung disease. In fact, lung ultrasound scores accurately estimate lung aeration, which is the amount of lung volume available for gas exchange, as this has been demonstrated in a plethora of animal and human studies [10]. For a uniform, homogeneous, and restrictive lung disease due to primary surfactant deficiency, the estimation of lung aeration is equivalent to an accurate description of oxygenation. In fact, lung ultrasound score accurately correlates, not with FiO2, but with all more sophisticated oxygenation metrics [11,12,13] that take into account at least some of the factors mentioned above that influence oxygenation status. Thus, lung ultrasound represents a mindset change and also a more pathophysiological approach to a complex problem that cannot be simplified.

A recent quality improvement project showed that when surfactant is given based on lung ultrasound score (versus the oxygen requirement), more babies received surfactant within 3 hours of life with less oxygen exposure; this has been called ESTHER (Echography-guided Surfactant THERapy) [14]. Rodriguez Fanjul and coworkers should be commended for being the first colleagues to confirm these results in a randomized controlled trial where lung ultrasound score and FiO2 thresholds are compared [15]. They applied the ESTHER policy and, notably, all infants in the first group reached the lung ultrasound score threshold before the momentous brink of 0.3 FiO2 demand and received surfactant within the first hour of life (versus 6 hours in the control group). Together, these two papers provide good evidence for a timelier and more physiology-based surfactant administration in preterm babies with RDS [14, 15]. Interestingly, the lung ultrasound-guided surfactant replacement reduced oxygen exposure but did not change the overall surfactant use. This is also important and consistent with data shown even in larger populations [16].

The study has its limitations as any other. For instance, the small sample size, the lack of blindness, and the enrolment of preterm neonates less than 32 weeks’ gestation rather than a population of extremely preterm infants [15]. However, the authors recognize these limitations, and their results are based on a solid pathophysiological background described above and supported by a large consisting adult critical care literature [10].

Surfactant has been given as almost universal prophylaxis at birth for years, then the need for an early rescue therapy has been finally recognized. Now, the time has come for an even more personalized, timely, physiology-driven treatment. This can only improve the general quality of neonatal care as lung ultrasound is non-invasive and requires minimal training and tools that are available also in low-income countries [17, 18]. More and above this, the ultrasound-guided surfactant administration can eventually improve important clinical outcomes, through the reduction of oxygen exposure and ventilatory need [9], provided by an earlier and more effective surfactant replacement in patients who really need it.