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With interest, I have read the article by Manios et al. about CORE-index as a screening tool for the early identification of infants that are potentially at higher risk for becoming obese at their childhood and adolescence [3]. I have the following comments.
Childhood obesity is an international public health problem leading to an increased risk of adult obesity and associated with mortality and morbidity [5]. Vitamin D may regulate adipose tissue mass, differentiation, and metabolism in ways that might contribute to overweight and/or obesity possibly by effects on lipogenesis and/or adipogenesis [1]. Vitamin D has been found to be a predictor significantly associated with overweight and/or obesity and other components of metabolic syndrome including raised plasma glucose concentration and insulin resistance [4]. Ekbom et al. [2] reported that higher vitamin D levels were related to a decreased lipid profile in obese children and adolescents.
In this context, considering close association of vitamin D with both childhood obesity and metabolic syndrome parameters, in order to predict childhood obesity, new scoring system including CORE-index and serum vitamin D level might be beneficial.
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Ekbom K, Marcus C (2016) Vitamin D deficiency is associated with prediabetes in obese Swedish children. Acta Paediatr 105:1192–1197. doi:10.1111/apa.13363
Manios Y, Vlachopapadopoulou E, Moschonis G, Karachaliou F, Psaltopoulou T, Koutsouki D, Bogdanis G, Carayanni V, Hatzakis A, Michalacos S (2016) Utility and applicability of the “Childhood Obesity Risk Evaluation” (CORE)-index in predicting obesity in childhood and adolescence in Greece from early life: the “National Action Plan for Public Health”. Eur J Pediatr 175:1989–1996
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Cerit, Z. Prediction of childhood obesity with or without vitamin D deficiency. Eur J Pediatr 176, 557 (2017). https://doi.org/10.1007/s00431-017-2860-9
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DOI: https://doi.org/10.1007/s00431-017-2860-9