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Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review

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Abstract

We report a 2-year-old Japanese boy without bone marrow involvement who developed a primary granulocytic sarcoma in his spinal canal. Tumour cells were positive for myeloperoxidase, MIC2, CD56 and, CD68 on formalin-fixed, paraffin-embedded tissue sections and CD13, CD33, CD45, and CD64 on acetone-fixed fresh frozen sections. Nine months after the initiation of treatment, the tumour had significantly regressed and the patient was able to walk with help. Conclusion:Our patient is the youngest case of granulocytic sarcoma of the spine without bone marrow involvement. Immunohistochemical methods are very helpful in establishing a diagnosis of granulocytic sarcoma.

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Abbreviations

AML :

acute myeloid leukaemia

GS :

granulocytic sarcoma

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Authors and Affiliations

  1. Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan

    Yusuke Shiozawa, Masahiro Saito & Yuichiro Yamashiro

  2. Department of Developmental Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, 154-8535, Tokyo , Japan

    Yusuke Shiozawa, Nobutaka Kiyokawa, Junichiro Fujimoto & Jun-ichi Hata

Authors
  1. Yusuke Shiozawa
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  2. Nobutaka Kiyokawa
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  3. Masahiro Saito
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  4. Junichiro Fujimoto
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  5. Jun-ichi Hata
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  6. Yuichiro Yamashiro
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Correspondence to Yusuke Shiozawa.

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Shiozawa, Y., Kiyokawa, N., Saito, M. et al. Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review. Eur J Pediatr 164, 616–620 (2005). https://doi.org/10.1007/s00431-005-1728-6

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  • DOI: https://doi.org/10.1007/s00431-005-1728-6

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