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Transient exocrine pancreatic insufficiency as a possible complication of an enterovirus infection

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Abstract

Exocrine pancreatic insufficiency is an exceptional problem in children, mostly associated with diseases like cystic fibrosis, Shwachman-Diamond syndrome or chronic pancreatitis, as is the case in idiopathic fibrosing pancreatitis. Many viral infections are known to cause acute pancreatitis. Most of them, however, are transient with no remaining damage. The differential diagnosis of persisting diarrhoea after gastrointestinal infection does not routinely include a search for exocrine pancreatic insufficiency. Conclusion: This is the first description of a child with a transient but severe exocrine pancreatic insufficiency probably induced by an ordinary enterovirus infection

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Fig. 1.

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Abbreviations

cPDR :

cumulative percentage absorption

FE-1 :

faecal elastase 1

MTG :

mixed triglyceride

PERT :

pancreatic exocrine replacement therapy

SPI :

secondary pancreatic insufficiency

References

  1. Amarri S, Harding M, Coward WA, Evans TJ, Weaver LT (1997) 13-Carbon mixed triglyceride breath test and pancreatic enzyme supplementation in cystic fibrosis. Arch Dis Child 76: 349–351

    CAS  PubMed  Google Scholar 

  2. Appelros S, Lindgren S, Borgstrom A (2001) Short and long term outcome of severe acute pancreatitis. Eur J Surg 167: 281–286

    Article  CAS  PubMed  Google Scholar 

  3. Doepel M, Eriksson J, Halme L, Kumpulainen T, Hockerstedt K (1993) Good long-term results in patients surviving severe acute pancreatitis. Br J Surg 80: 1499–1500

    PubMed  Google Scholar 

  4. Jackson WD (2001) Pancreatitis: etiology, diagnosis and management. Curr Opin Pediatr 13: 447–451

    Article  CAS  PubMed  Google Scholar 

  5. Leus J, Van Biervliet S, Robberecht E (2000) Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review. Eur J Pediatr 159: 563–568

    Article  CAS  PubMed  Google Scholar 

  6. Salvatore S, Finazzi S, Melzi d'Eril GV, Tosi A, Verzeletti M, Nespoli I (2000) Low fecal elastase: could it be also related to small bowel damage? J Pediatr Gastroenterol Nutr 31[Suppl 2]: S221

  7. Salvatore S, Finazzi S, Barassi A, Verzeletti M, Tosi A, Melzi d'Eril GV, Nespoli L (2003) Low faecal elastase: potentially related to transient small bowel damage resulting from enteric pathogens. J Pediatr Gastroenterol Nutr 36: 392–396

    Article  CAS  PubMed  Google Scholar 

  8. Vantrappen GR, Rutgeers PJ, Ghoos YF, Hiele MI (1989) Mixed triglyceride breath test: a noninvasive test of pancreatic lipase activity in the duodenum. Gastroenterology 96: 1126–1134

    CAS  PubMed  Google Scholar 

  9. Walker-Smith J, Murch S (1999) Gastroenteritis and its sequelae. In: Walker-Smith J, Murch S (eds) Diseases of the small intestine in childhood, 4th edn. ISIS Medical Media, Oxford, pp 119–194

  10. Walkowiak J, Herzig KH (2001) Fecal elastase-I is decreased in villous atrophy regardless of the underlying disease. Eur J Clin Invest 31: 425–430

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatric Gastroenterology and Nutrition, University Hospital Ghent, De Pintelaan 185, 9000 , Gent, Belgium

    Stephanie Van Biervliet, Kathleen De Waele, Myriam Van Winckel & Eddy Robberecht

Authors
  1. Stephanie Van Biervliet
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  2. Kathleen De Waele
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  3. Myriam Van Winckel
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  4. Eddy Robberecht
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Correspondence to Stephanie Van Biervliet.

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Van Biervliet, S., De Waele, K., Van Winckel, M. et al. Transient exocrine pancreatic insufficiency as a possible complication of an enterovirus infection. Eur J Pediatr 162, 872–874 (2003). https://doi.org/10.1007/s00431-003-1315-7

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  • DOI: https://doi.org/10.1007/s00431-003-1315-7

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