Skip to main content

Advertisement

SpringerLink
Log in

Could JC virus be linked to chronic idiopathic intestinal pseudo-obstruction?

  • Case Report
  • Published:
Clinical Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

JC virus is a member of the Polyomavirus family, infects humans worldwide, and 90% of the population carry antibodies to the virus by adult life. The initial infection is asymptomatic, but it may become persistent. JC virus DNA is frequently present in the upper and lower gastrointestinal tracts of healthy adults. Chronic idiopathic intestinal pseudo-obstruction, one of the most severe gastrointestinal motility disorders, is a condition characterized by a clinical picture mimicking small bowel occlusion with related symptoms and signs in the absence of demonstrable mechanical obstruction. Because of the known neuropathic capability of this virus, and its frequent presence in the gut, it has been proposed that JCV might be detectable in tissues of patients with chronic idiopathic intestinal pseudo-obstruction, and possibly be involved in the pathogenesis of this disease, because the virus may actively infect the enteroglial cells of the myenteric plexuses of the patients with chronic idiopathic intestinal pseudo-obstruction. We report two cases of upper idiopathic intestinal pseudo-obstruction associated with JCV infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Abbreviations

JCV:

JC virus

CIIPO:

Chronic idiopathic intestinal pseudo-obstruction

SMA:

Smooth muscle antibodies

LKM:

Liver kidney microsome antibodies

AMA:

Anti-mitochondrial antibodies

ANCA:

Antineutrophil cytoplasmic antibodies

ANA:

Anti-nuclear antibodies

TTG:

Anti-tissue transglutaminase

HBV:

Hepatitis B virus

HCV:

Hepatitis C virus

HIV:

Human immunodeficiency virus

CMV:

Cytomegalovirus

EBV:

Epstein Barr virus

HSV:

Herpes simplex virus

CT:

Computed tomography

TPN:

Total parenteral nutrition

PPI:

Proton pump inhibitor

PCR:

Polymerase chain reaction

References

  1. Knowles WA. Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV). Adv Exp Med Biol. 2006;577:19–45 (Review. PubMed PMID: 16626025).

    Article  CAS  PubMed  Google Scholar 

  2. Sinagra E, Raimondo D, Gallo E, Stella M, Cottone M, Orlando A, Rossi F, Orlando E, Messina M, Tomasello G, Lo Monte AI, La Rocca E, Rizzo AG. Could JC virus provoke metastasis in colon cancer? World J Gastroenterol. 2014;20(42):15745–9. https://doi.org/10.3748/wjg.v20.i42.15745(PubMed PMID: 25400458; PubMed Central PMCID: PMC4229539).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Laghi L, Randolph AE, Chauhan DP, Marra G, Major EO, Neel JV, Boland CR. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci USA. 1999;96(13):7484–9 (PubMed PMID: 10377441; PubMed Central PMCID: PMC22112).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ricciardiello L, Laghi L, Ramamirtham P, Chang CL, Chang DK, Randolph AE, Boland CR. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology. 2000;119(5):1228–355 (PubMed PMID: 11054380).

    Article  CAS  PubMed  Google Scholar 

  5. De Giorgio R, Ricciardiello L, Naponelli V, Selgrad M, Piazzi G, Felicani C, Serra M, Fronzoni L, Antonucci A, Cogliandro RF, Barbara G, Corinaldesi R, Tonini M, Knowles CH, Stanghellini V. Chronic intestinal pseudo-obstruction related to viral infections. Transplant Proc. 2010;42(1):9–14. https://doi.org/10.1016/j.transproceed.2009.12.014(PubMed PMID: 20172270).

    Article  PubMed  Google Scholar 

  6. Padgett BL, Walker DL, ZuRhein GM, et al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet. 1971;1:1257.

    Article  CAS  PubMed  Google Scholar 

  7. Maginnis MS, Atwood WJ. JC virus: an oncogenic virus in animals and humans? Semin Cancer Biol. 2009;19(4):261–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Engsig FN, Hansen AB, Omland LH, Kronborg G, Gerstoft J, Laursen AL, Pedersen C, Mogensen CB, Nielsen L, Obel N. Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study. J Infect Dis. 2009;199(1):77–83.

    Article  PubMed  Google Scholar 

  9. Bozic C, Subramanyam M, Richman S, Plavina T, Zhang A, Ticho B. Anti-JC virus (JCV) antibody prevalence in the JCV Epidemiology in MS (JEMS) trial. Eur J Neurol. 2014;21(2):299–304.

    Article  CAS  PubMed  Google Scholar 

  10. Selgrad M, De Giorgio R, Fini L, Cogliandro RF, Williams S, Stanghellini V, Barbara G, Tonini M, Corinaldesi R, Genta RM, Domiati-Saad R, Meyer R, Goel A, Boland CR, Ricciardiello L. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut. 2009;58(1):25–322. https://doi.org/10.1136/gut.2008.152512 (Epub 2008 Jul 1. PubMed PMID: 18593810; PubMed Central PMCID: PMC2865195).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endoscopy Unit, Contrada Pietra Pollastra Pisciotto, Fondazione Istituto San Raffaele–G. Giglio, 90015, Cefalù, Italy

    Emanuele Sinagra & Dario Raimondo

  2. Unit of Pathology, Ospedali Riuniti “Villa Sofia–Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy

    Elena Gallo, Vincenzo Luca Lentini, Alessandra Cannizzaro & Aroldo Gabriele Rizzo

  3. Unit of Gastroenterology, Ospedali Riuniti “Villa Sofia–Cervello, University of Palermo, via trabucco 180, 90136, Palermo, Italy

    Cristina Linea, Marco Giunta, Luigi Maria Montalbano & Gennaro D’Amico

  4. Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy

    Emanuele Sinagra

  5. Contrada Pietra Pollastra Pisciotto, Istituto Di Bioimmagini E Fisiologia Molecolare, IBFM-CNR, 90015, Cefalù, Italy

    Marco Calvaruso

Authors
  1. Emanuele Sinagra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dario Raimondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elena Gallo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marco Calvaruso
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vincenzo Luca Lentini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alessandra Cannizzaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Cristina Linea
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Marco Giunta
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Luigi Maria Montalbano
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Gennaro D’Amico
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Aroldo Gabriele Rizzo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Vincenzo Luca Lentini.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sinagra, E., Raimondo, D., Gallo, E. et al. Could JC virus be linked to chronic idiopathic intestinal pseudo-obstruction?. Clin J Gastroenterol 13, 377–381 (2020). https://doi.org/10.1007/s12328-019-01069-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12328-019-01069-4

Keywords

Search

Navigation