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Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria

  • Developments in Filariasis Research
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Abstract.

River blindness is thought to occur as a result of the host response to degenerating microfilariae in the eye. Utilizing a murine model of corneal inflammation (keratitis) to investigate the immune and inflammatory responses associated with river blindness, we recently demonstrated an important role for endotoxin-like products from endosymbiotic bacteria and for activation of Toll-like receptor 4 (TLR4). These observations have led to a new understanding of the pathogenesis of this disease

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  1. Center for Global Health and Diseases, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA, , , , ,

    Eric Pearlman

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  1. Eric Pearlman
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Pearlman, E. Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria. Med Microbiol Immunol 192, 57–60 (2003). https://doi.org/10.1007/s00430-002-0160-z

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  • DOI: https://doi.org/10.1007/s00430-002-0160-z

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