Abstract
A modified and extended version, HCPex, is provided of the surface-based Human Connectome Project-MultiModal Parcellation atlas of human cortical areas (HCP-MMP v1.0, Glasser et al. 2016). The original atlas with 360 cortical areas has been modified in HCPex for ease of use with volumetric neuroimaging software, such as SPM, FSL, and MRIcroGL. HCPex is also an extended version of the original atlas in which 66 subcortical areas (33 in each hemisphere) have been added, including the amygdala, thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, mammillary bodies, septal nuclei and nucleus basalis. HCPex makes available the excellent parcellation of cortical areas in HCP-MMP v1.0 to users of volumetric software, such as SPM and FSL, as well as adding some subcortical regions, and providing labelled coronal views of the human brain.
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Acknowledgements
The use of the HCP-MMP v1.0 atlas (Glasser et al. 2016a, b) in the construction of HCPex is acknowledged, and reference should be made to that paper if use is made of HCPex. The volumetric version of the Glasser et al. atlas (2016a) produced by Coalson et al. (2018) was downloaded with grateful acknowledgement from the publicly released version of the parcellation (https://balsa.wustl.edu/file/show/nvrZ). The neuroimaging data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. Professor Laszlo Zaborszky is warmly thanked for providing a parcellation of the Ch1-Ch4 nuclei based on Zaborszky et al. (2008).
Funding
This research was supported by a grant to Professor C-P. Lin that included research with Professor E.T. Rolls (Ministry of Science and Technology (MOST) of Taiwan, MOST 110-2321-B-010-010-004 and MOST 110-2634-F-010-001). The research was also supported by the following grants to Professor J. Feng: National Key R&D Program of China (No. 2019YFA0709502); 111 Project (No. B18015); Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01), ZJLab, and Shanghai Center for Brain Science and Brain-Inspired Technology; and National Key R&D Program of China (No. 2018YFC1312904). The funding agencies took no part in the design of this research.
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C–C Huang and E T Rolls prepared the atlas and wrote the paper. C-P Lin and J.Feng read and approved the paper, and provided funding.
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No data were collected as part of the research described here. The data were from the Human Connectome Project, and the WU-Minn HCP Consortium obtained full informed consent from all participants, and research procedures and ethical guidelines were followed in accordance with the Institutional Review Boards (IRB), with details at the HCP website (http://www.humanconnectome.org/).
Software and code for the extended HCP atlas
The HCPex atlas, including its different versions, labels, code, and the User guide, is available in association with this paper at the authors’ websites https://www.oxcns.org as HCPex_v1.0.zip and https://github.com/wayalan/HCPex.
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Huang, CC., Rolls, E.T., Feng, J. et al. An extended Human Connectome Project multimodal parcellation atlas of the human cortex and subcortical areas. Brain Struct Funct 227, 763–778 (2022). https://doi.org/10.1007/s00429-021-02421-6
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DOI: https://doi.org/10.1007/s00429-021-02421-6