Abstract
The somite and its intermediate derivatives, sclerotome and dermomyotome (DM), are composed of distinct subdomains based on lineage analysis and gene expression patterns. This sets the grounds for elucidating the mechanisms underlying differential cell specification and morphogenesis. By examining the in vivo roles of N-cadherin on discrete domains of the somitic epithelium at various times, our recent studies highlight the existence of a regional and temporal heterogeneity in cellular responsiveness. As examples of this assortment, we document a coupling between asymmetric cell division and fate segregation in the DM sheet, sequential effects of N-cadherin-mediated adhesion on early myogenic specification compared to later myofiber patterning, and a differential behavior of pioneer myoblasts compared to later myogenic waves.
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Acknowledgments
We thank M. Takeichi for the N-cadherin DNAs and D. Duprez for MyoD. This work was supported by grants from the Israel Science Foundation, the EEU 6th Framework program Network of Excellence MYORES, the March of Dimes and DFG (SFB 488) to C.K.
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Yuval Cinnamon and Raz Ben-Yair have equally contributed data presented in this study.
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Kalcheim, C., Kahane, N., Cinnamon, Y. et al. Mechanisms of lineage segregation in the avian dermomyotome. Brain Struct Funct 211 (Suppl 1), 31–36 (2006). https://doi.org/10.1007/s00429-006-0116-y
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DOI: https://doi.org/10.1007/s00429-006-0116-y