GBD 2017 Inflammatory Bowel Disease Collaborators (2020) The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 5:17–30. https://doi.org/10.1016/S2468-1253(19)30333-4
Article
Google Scholar
Kucharzik A, Dignass AU, Atreya R et al (2018) Updated S3-Guideline colitis ulcerosa. German Society for Digestive and Metabolic Diseases (DGVS) - AWMF Registry 021/009. Z Gastroenterol 56:1087–1169
Article
Google Scholar
Allison MC, Hamilton-Dutoit SJ, Dhillon AP et al (1987) The value of rectal biopsy in distinguishing self-limited colitis from early inflammatory bowel disease. Q J Med 65:985–995
CAS
PubMed
Google Scholar
Bentley E, Jenkins D, Campbell F, Warren B (2002) How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop. J Clin Pathol 55:955–960. https://doi.org/10.1136/jcp.55.12.955
CAS
Article
PubMed
PubMed Central
Google Scholar
Dejaco C, Oesterreicher C, Angelberger S, Püspök A, Birner P, Poetzi R, Gangl A, Oberhuber G (2003) Diagnosing colitis: a prospective study on essential parameters for reaching a diagnosis. Endoscopy 35:1004–1008. https://doi.org/10.1055/s-2003-44593
CAS
Article
PubMed
Google Scholar
Dube AK, Cross SS, Lobo AJ (1998) Audit of the histopathological diagnosis of non-neoplastic colorectal biopsies: achievable standards for the diagnosis of inflammatory bowel disease. J Clin Pathol 51:378–381. https://doi.org/10.1136/jcp.51.5.378
CAS
Article
PubMed
PubMed Central
Google Scholar
Dundas SA, Dutton J, Skipworth P (1997) Reliability of rectal biopsy in distinguishing between chronic inflammatory bowel disease and acute self-limiting colitis. Histopathology 31:60–66. https://doi.org/10.1046/j.1365-2559.1997.5810818.x
CAS
Article
PubMed
Google Scholar
Jenkins D, Balsitis M, Gallivan S, Dixon MF, Gilmour HM, Shepherd NA, Theodossi A, Williams GT (1997) Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol 50:93–105
CAS
Article
Google Scholar
Nostrant TT, Kumar NB, Appelman HD (1987) Histopathology differentiates acute self-limited colitis from ulcerative colitis. Gastroenterology 92:318–328. https://doi.org/10.1016/0016-5085(87)90124-7
CAS
Article
PubMed
Google Scholar
Schumacher G, Kollberg B, Sandstedt B (1994) A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation. Scand J Gastroenterol 29:318–332. https://doi.org/10.3109/00365529309098313
CAS
Article
PubMed
Google Scholar
Seldenrijk CA, Morson BC, Meuwissen SG, Schipper NW, Lindeman J, Meijer CJ (1991) Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut 32:1514–1520. https://doi.org/10.1136/gut.32.12.1514
CAS
Article
PubMed
PubMed Central
Google Scholar
Surawicz CM, Belic L (1984) Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease. Gastroenterology 86:104–113
CAS
Article
Google Scholar
Tanaka M, Masuda T, Yao T, Saito H, Kusumi T, Nagura H, Kudo H (2001) Observer variation of diagnoses based on simple biopsy criteria differentiating among Crohnʼs disease, ulcerative colitis, and other forms of colitis. J Gastroenterol Hepatol 16:1368–1372. https://doi.org/10.1046/j.1440-1746.2001.02638.x
CAS
Article
PubMed
Google Scholar
Tanaka M, Riddell RH, Saito H, Soma Y, Hidaka H, Kudo H (1999) Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohnʼs disease from ulcerative colitis. Scand J Gastroenterol 34:55–67. https://doi.org/10.1080/00365529950172844
CAS
Article
PubMed
Google Scholar
Tanaka M, Saito H, Fukuda S, Sasaki Y, Munakata A, Kudo H (2000) Simple mucosal biopsy criteria differentiating among Crohn disease, ulcerative colitis, and other forms of colitis: measurement of validity. Scand J Gastroenterol 35:281–286. https://doi.org/10.1080/003655200750024155
CAS
Article
PubMed
Google Scholar
Theodossi A, Spiegelhalter DJ, Jass J, Firth J, Dixon M, Leader M, Levison DA, Lindley R, Filipe I, Price A (1994) Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. Gut 35:961–968. https://doi.org/10.1136/gut.35.7.961
CAS
Article
PubMed
PubMed Central
Google Scholar
Langner C, Magro F, Driessen A, Ensari A, Mantzaris GJ, Villanacci V, Becheanu G, Borralho Nunes P, Cathomas G, Fries W, Jouret-Mourin A, Mescoli C, de Petris G, Rubio CA, Shepherd NA, Vieth M, Eliakim R, Geboes K (2014) The histopathological approach to inflammatory bowel disease: a practice guide. Virchows Arch 464(5):511–527. https://doi.org/10.1007/s00428-014-1543-4
CAS
Article
PubMed
Google Scholar
Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE (2018) ACG clinical guideline: management of Crohn’s disease in adults. Am J Gastroenterol 113:481–517. https://doi.org/10.1038/ajg.2018.27
Article
PubMed
Google Scholar
Rubin DT, Ananthakrishnan AN, Siegel CA, Sauer BG, Long MD (2019) ACG clinical guideline: ulcerative colitis in adults. Am J Gastroenterol 114:384–413. https://doi.org/10.14309/ajg.0000000000000152
Article
PubMed
Google Scholar
Riley SA, Mani V, Goodman MJ, Dutt S, Herd ME (1991) Microscopic activity in ulcerative colitis: what does it mean? Gut 32:174–178. https://doi.org/10.1136/gut.32.2.174
CAS
Article
PubMed
PubMed Central
Google Scholar
Bitton A, Peppercorn MA, Antonioli DA, Niles JL, Shah S, Bousvaros A, Ransil B, Wild G, Cohen A, Deb Edwardes MD, Stevens AC (2001) Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology 120:13–20. https://doi.org/10.1053/gast.2001.20912
CAS
Article
PubMed
Google Scholar
Neurath MF, Travis SP (2012) Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 61:1619–1635. https://doi.org/10.1136/gutjnl-2012-302830
CAS
Article
PubMed
Google Scholar
Truelove SC, Richards WC (1956) Biopsy studies in ulcerative colitis. Br Med J 1:1315–1318. https://doi.org/10.1136/bmj.1.4979.1315
CAS
Article
PubMed
PubMed Central
Google Scholar
Frøslie KF, Jahnsen J, Moum BA, Vatn MH (2007) Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 133:412–422. https://doi.org/10.1053/j.gastro.2007.05.051
Article
PubMed
Google Scholar
Colombel JF, Rutgeerts P, Reinisch W, Esser D, Wang Y, Lang Y, Marano CW, Strauss R, Oddens BJ, Feagan BG, Hanauer SB, Lichtenstein GR, Present D, Sands BE, Sandborn WJ (2011) Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 141:1194–1201. https://doi.org/10.1053/j.gastro.2011.06.054
CAS
Article
PubMed
Google Scholar
Sandborn WJ, Rutgeerts P, Feagan BG, Reinisch W, Olson A, Johanns J, Lu J, Horgan K, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJS, Present D, Sands BE, Colombel JF (2009) Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology 137:1250–1260. https://doi.org/10.1053/j.gastro.2009.06.061
CAS
Article
PubMed
Google Scholar
Feagan BG, Reinisch W, Rutgeerts P, Sandborn WJ, Yan S, Eisenberg D, Bala M, Johanns J, Olson A, Hanauer SB (2007) The effects of infliximab therapy on health-related quality of life in ulcerative colitis patients. Am J Gastroenterol 102:794–802. https://doi.org/10.1111/j.1572-0241.2007.01094.x
CAS
Article
PubMed
Google Scholar
Peyrin-Biroulet L, Sandborn W, Sands BE, Reinisch W, Bemelman W, Bryant RV, DʼHaens G, Dotan I, Dubinsky M, Feagan B, Fiorino G, Gearry R, Krishnareddy S, Lakatos PL, Loftus EV Jr, Marteau P, Munkholm P, Murdoch TB, Ordás I, Panaccione R, Riddell RH, Ruel J, Rubin DT, Samaan M, Siegel CA, Silverberg MS, Stoker J, Schreiber S, Travis S, van Assche G, Danese S, Panes J, Bouguen G, OʼDonnell S, Pariente B, Winer S, Hanauer S, Colombel JF (2015) Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): determining therapeutic goals for treat-to-target. Am J Gastroenterol 110:1324–1328. https://doi.org/10.1038/ajg.2015.233
CAS
Article
PubMed
Google Scholar
Bessissow T, Lemmens B, Ferrante M, Bisschops R, van Steen K, Geboes K, van Assche G, Vermeire S, Rutgeerts P, de Hertogh G (2012) Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing. Am J Gastroenterol 107:1684–1692. https://doi.org/10.1038/ajg.2012.301
Article
PubMed
Google Scholar
Park S, Abdi T, Gentry M, Laine L (2016) Histological disease activity as a predictor of clinical relapse among patients with ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol 111:1692–1701. https://doi.org/10.1038/ajg.2016.418
Article
PubMed
Google Scholar
Rubin DT, Huo D, Kinnucan JA, Sedrak MS, McCullom NE, Bunnag AP, Raun–Royer EP, Cohen RD, Hanauer SB, Hart J, Turner JR (2013) Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study. Clin Gastroenterol Hepatol 11:1601–1608. https://doi.org/10.1016/j.cgh.2013.06.023
Article
PubMed
Google Scholar
Gupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, Ullman T (2007) Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 133:1099–1105. https://doi.org/10.1053/j.gastro.2007.08.001
Article
PubMed
PubMed Central
Google Scholar
Hefti MM, Chessin DB, Harpaz NH, Steinhagen RM, Ullman TA (2009) Severity of inflammation as a predictor of colectomy in patients with chronic ulcerative colitis. Dis Colon Rectum 52:193–197. https://doi.org/10.1007/DCR.0b013e31819ad456
Article
PubMed
PubMed Central
Google Scholar
Bryant RV, Burger DC, Delo J, Walsh AJ, Thomas S, von Herbay A, Buchel OC, White L, Brain O, Keshav S, Warren BF, Travis SPL (2016) Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up. Gut 65(3):408–414. https://doi.org/10.1136/gutjnl-2015-309598
CAS
Article
PubMed
Google Scholar
Peyrin-Biroulet L, Bressenot A, Kampman W (2014) Histologic remission: the ultimate therapeutic goal in ulcerative colitis? Clin Gastroenterol Hepatol 12:929–934. https://doi.org/10.1016/j.cgh.2013.07.022
Article
PubMed
Google Scholar
Feagins LA, Melton SD, Iqbal R, Dunbar KB, Spechler SJ (2013) Clinical implications of histologic abnormalities in colonic biopsy specimens from patients with ulcerative colitis in clinical remission. Inflamm Bowel Dis 18:1477–1482. https://doi.org/10.1097/MIB.0b013e318281f4ae
Article
Google Scholar
Christensen B, Hanauer SB, Erlich J, Kassim O, Gibson PR, Turner JR, Hart J, Rubin DT (2017) Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes. Clin Gastroenterol Hepatol 15:1557–1564. https://doi.org/10.1016/j.cgh.2017.02.016
Article
PubMed
PubMed Central
Google Scholar
Food and Drug Administration. Ulcerative colitis: clinical trial endpoints guidance for industry. Draft Guidance. Silver Spring, MD: FDA; p. 19. Report No.: 15028dft.doc 07/27/16 UCM515143. Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/ulcerative-colitis-clinical-trial-endpoints-guidance-industry.
Novak G, Parker CE, Pai RK, MacDonald JK, Feagan BG, Sandborn WJ, D’Haens G, Jairath V, Khanna R (2017) Histologic scoring indices for evaluation of disease activity in Crohn’s disease. Cochrane Database Syst Rev 7:CD012351. https://doi.org/10.1002/14651858.CD012351.pub2
Article
PubMed
Google Scholar
Mosli MH, Parker CE, Nelson SA et al (2017) Histologic scoring indices for evaluation of disease activity in ulcerative colitis. Cochrane Database Syst Rev 5:CD011256. https://doi.org/10.1002/14651858.CD011256.pub2
Article
PubMed
Google Scholar
Magro F, Doherty G, Peyrin-Biroulet L et al (2020) ECCO position paper: harmonization of the approach to ulcerative colitis histopathology. J Crohns Colitis 14(11):1503–1511. https://doi.org/10.1093/ecco-jcc/jjaa110 [Published Online ahead of print]
Article
PubMed
Google Scholar
Likert R (1932) A technique for the measurement of attitudes. In: Archives of Psychology 22(140):55
Google Scholar
Gomollón F, Dignass A, Annese V, Tilg H, van Assche G, Lindsay JO, Peyrin-Biroulet L, Cullen GJ, Daperno M, Kucharzik T, Rieder F, Almer S, Armuzzi A, Harbord M, Langhorst J, Sans M, Chowers Y, Fiorino G, Juillerat P, Mantzaris GJ, Rizzello F, Vavricka S, Gionchetti P, on behalf of ECCO (2017) 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: part 1: diagnosis and medical management. J Crohns Colitis 11:3–25. https://doi.org/10.1093/ecco-jcc/jjw168
Article
PubMed
Google Scholar
Feakins RM (2013) Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines. J Clin Pathol 66:1–22. https://doi.org/10.1136/jclinpath-2013-201885
Article
Google Scholar
Stange EF, Travis SPL, Vermeire S, Reinisch W, Geboes K, Barakauskiene A, Feakins R, Fléjou JF, Herfarth H, Hommes DW, Kupcinskas L, Lakatos PL, Mantzaris GJ, Schreiber S, Villanacci V, Warren BF, European Crohn's and Colitis Organisation (ECCO) (2008) European evidence-based consensus on the diagnosis and management of ulcerative colitis: definitions and diagnosis. J Crohns Colitis 2:1–23. https://doi.org/10.1016/j.crohns.2007.11.001
CAS
Article
PubMed
Google Scholar
Stange EF, Travis SPL, Vermeire S, Beglinger C, Kupcinkas L, Geboes K, Barakauskiene A, Villanacci V, von Herbay A, Warren BF, Gasche C, Tilg H, Schreiber SW, Schölmerich J, Reinisch W, European Crohn's and Colitis Organisation (2006) European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. Gut 55(suppl 1):1–15. https://doi.org/10.1136/gut.2005.081950a
Article
Google Scholar
Bernstein C, Eliakim A, Fedail S, Fried M, Gearry R, Goh KL, Hamid S, Khan AG, Khalif I, Ng SC, Ouyang Q, Rey JF, Sood A, Steinwurz F, Watermeyer G, LeMair A, Review Team (2015) World Gastroenterology Organisation Global Guidelines Inflammatory Bowel Disease: update August 2015. J Clin Gastroenterol 50(10):803–818. https://doi.org/10.1097/MCG.0000000000000660
Article
Google Scholar
Magro F, Langner C, Driessen A, Ensari A, Geboes K, Mantzaris GJ, Villanacci V, Becheanu G, Borralho Nunes P, Cathomas G, Fries W, Jouret-Mourin A, Mescoli C, de Petris G, Rubio CA, Shepherd NA, Vieth M, Eliakim R, European Society of Pathology (ESP), European Crohn's and Colitis Organisation (ECCO) (2013) European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis 7:827–851. https://doi.org/10.1016/j.crohns.2013.06.001
CAS
Article
PubMed
Google Scholar
Dignass A, Eliakim R, Magro F, Maaser C, Chowers Y, Geboes K, Mantzaris G, Reinisch W, Colombel JF, Vermeire S, Travis S, Lindsay JO, van Assche G (2012) Second European evidence-based consensus on the diagnosis and management of ulcerative colitis. Part 1: definitions and diagnosis. J Crohns Colitis 6(10):965–990. https://doi.org/10.1016/j.crohns.2012.09.003
Article
PubMed
Google Scholar
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B’H, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H, IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB (2019) British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut 68(Suppl 3):s1–s106. https://doi.org/10.1136/gutjnl-2019-318484
Article
PubMed
PubMed Central
Google Scholar
Sharaf RN, Shergill AK, Odze RD et al (2013) Endoscopic mucosal tissue sampling. Gastrointest Endosc 78(2):216–224. https://doi.org/10.1016/j.gie.2013.04.167
Article
PubMed
Google Scholar
OCEBM Levels of Evidence Working Group. The Oxford 2011 Levels of Evidence. Oxford Centre for Evidence-Based Medicine. http://www.cebm.net/index.aspx?o=565.
Annese V, Daperno M, Rutter MD, Amiot A, Bossuyt P, East J, Ferrante M, Götz M, Katsanos KH, Kießlich R, Ordás I, Repici A, Rosa B, Sebastian S, Kucharzik T, Eliakim R, European Crohn's and Colitis Organisation (2013) European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis 7:982–1018. https://doi.org/10.1016/j.crohns.2013.09.016
Article
PubMed
Google Scholar
Carter MJ, Lobo AJ, Travis SP (2004) IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut 53(Suppl 5):1–16. https://doi.org/10.1136/gut.2004.043372
Article
Google Scholar
Feakins RM, Campbell F, Mears L et al (2009) Tissue pathways for gastrointestinal and hepatopancreatobiliary pathology. Royal College of Pathologists, London
Google Scholar
Carbonnel F, Lavergne A, Lemann M et al (1994) Colonoscopy of acute colitis. A safe and reliable tool for assessment of severity. Dig Dis Sci 39:1550–1557. https://doi.org/10.1007/BF02088063
CAS
Article
PubMed
Google Scholar
Washington K, Greenson JK, Montgomery E, Shyr Y, Crissinger KD, Polk DB, Barnard J, Lauwers GY (2002) Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol 26:1441–1449. https://doi.org/10.1097/00000478-200211000-00006
Article
PubMed
Google Scholar
Coremans G, Rutgeerts P, Geboes K, van den Oord J, Ponette E, Vantrappen G (1984) The value of ileoscopy with biopsy in the diagnosis of intestinal Crohn’s disease. Gastrointest Endosc 30:167–172. https://doi.org/10.1016/s0016-5107(84)72358-3
CAS
Article
PubMed
Google Scholar
Alemayehu G, Jarnerot G (1991) Colonoscopy during an attack of severe ulcerative colitis is a safe procedure and of great value in clinical decision making. Am J Gastroenterol 86:187–190
CAS
PubMed
Google Scholar
Kleer CG, Appelman HD (1998) Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time. Am J Surg Pathol 22:983–989. https://doi.org/10.1097/00000478-199808000-00008
CAS
Article
PubMed
Google Scholar
Mutinga ML, Odze RD, Wang HH, Hornick JL, Farraye FA (2004) The clinical significance of right-sided colonic inflammation in patients with left-sided chronic ulcerative colitis. Inflamm Bowel Dis 10:215–219. https://doi.org/10.1097/00054725-200405000-00006
Article
PubMed
Google Scholar
Scott IS, Sheaff M, Coumbe A, Feakins RM, Rampton DS (1998) Appendiceal inflammation in ulcerative colitis. Histopathology 33:168–173. https://doi.org/10.1046/j.1365-2559.1998.00477.x
CAS
Article
PubMed
Google Scholar
Odze R (2003) Diagnostic problems and advances in inflammatory bowel disease. Mod Pathol 16:347–358. https://doi.org/10.1097/01.MP.0000064746.82024.D1
Article
PubMed
Google Scholar
D’Haens G, Geboes K, Peeters M et al (1997) Patchy cecal inflammation associated with distal ulcerative colitis: a prospective endoscopic study. Am J Gastroenterol 92:1275–1279
PubMed
Google Scholar
Kroft SH, Stryker SJ, Rao MS (1994) Appendiceal involvement as a skip lesion in ulcerative colitis. Mod Pathol 7:912–914
CAS
PubMed
Google Scholar
Bernstein CN, Shanahan F, Anton PA, Weinstein WM (1995) Patchiness of mucosal inflammation in treated ulcerative colitis: a prospective study. Gastrointest Endosc 42:232–237. https://doi.org/10.1016/s0016-5107(95)70097-8
CAS
Article
PubMed
Google Scholar
Geboes K (2001) Pathology of inflammatory bowel diseases (IBD): variability with time and treatment. Color Dis 3:2–12. https://doi.org/10.1046/j.1463-1318.2001.00187.x
CAS
Article
Google Scholar
Markowitz J, Kahn E, Grancher K, Hyams J, Treem W, Daum F (1993) Atypical rectosigmoid histology in children with newly diagnosed ulcerative colitis. Am J Gastroenterol 88:2034–2037
CAS
PubMed
Google Scholar
Robert ME, Tang L, Hao LM, Reyes-Mugica M (2004) Patterns of inflammation in mucosal biopsies of ulcerative colitis: perceived differences in pediatric populations are limited to children younger than 10 years. Am J Surg Pathol 28:183–189. https://doi.org/10.1097/00000478-200402000-00005
CAS
Article
PubMed
Google Scholar
Tanaka M, Riddell RH (1990) The pathological diagnosis and differential diagnosis of Crohn’s disease. Hepatogastroenterology 37:18–31
CAS
PubMed
Google Scholar
Marshall JK, Thabane M, Steinhart AH, Newman JR, Anand A, Irvine EJ, Cochrane IBD Group (2010) Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 20:CD004115. https://doi.org/10.1002/14651858.CD004115.pub2
Article
Google Scholar
Lie MR, Kanis SL, Hansen BE et al (2014) Drug therapies for ulcerative proctitis: systematic review and meta-analysis. Inflamm Bowel Dis 20:2157–2178. https://doi.org/10.1097/MIB.0000000000000141
Article
PubMed
Google Scholar
Cohen RD, Dalal SR (2015) Systematic review: Rectal therapies for the treatment of distal forms of ulcerative colitis. Inflamm Bowel Dis 21:1719–1736. https://doi.org/10.1097/MIB.0000000000000379
Article
PubMed
Google Scholar
Geboes K, Dalle I (2002) Influence of treatment on morphological features of mucosal inflammation. Gut 50:iii37–iii42. https://doi.org/10.1136/gut.50.suppl_3.iii37
Article
PubMed
PubMed Central
Google Scholar
Mosli MH, Feagan BG, Sandborn WJ, DʼHaens G, Behling C, Kaplan K, Driman DK, Shackelton LM, Baker KA, MacDonald JK, Vandervoort MK, Geboes K, Levesque BG (2014) Histologic evaluation of ulcerative colitis: a systematic review of disease activity indices. Inflamm Bowel Dis 20(3):564–575. https://doi.org/10.1097/01.MIB.0000437986.00190.71
Article
PubMed
Google Scholar
Odze R, Antonioli D, Peppercorn M, Goldman H (1993) Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. Am J Surg Pathol 27:869–875. https://doi.org/10.1097/00000478-199309000-00002
Article
Google Scholar
Fournier BM, Parkos CA (2012) The role of neutrophils during intestinal inflammation. Mucosal Immunol 5(4):354–366. https://doi.org/10.1038/mi.2012.24
CAS
Article
PubMed
Google Scholar
Billioud V, Ford AC, Del Tedesco E et al (2013) Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis. J Crohn Colitis 7(11):853–867. https://doi.org/10.1016/j.crohns.2013.01.014
Article
Google Scholar
Herfarth H, Tjaden C, Lukas M et al (2006) Adverse events in clinical trials with azathioprine and mesalamine for prevention of postoperative recurrence of Crohn’s disease. Gut 55(10):1525–1526
CAS
PubMed
PubMed Central
Google Scholar
D’Haens GR, Vermeire S, Van Assche G et al (2008) Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn’s disease: a controlled randomized trial. Gastroenterology 135(4):1123–1129. https://doi.org/10.1053/j.gastro.2008.07.010
CAS
Article
PubMed
Google Scholar
Nos P, Hinojosa J, Aguilera V, Moles JR et al (2000) Azathioprine and 5-ASA in the prevention of postoperative recurrence of Crohn’s disease. Gastroenterol Hepatol 23(8):374–378
CAS
PubMed
Google Scholar
Reinisch W, Angelberger S, Petritsch W, Shonova O, Lukas M, Bar-Meir S, Teml A, Schaeffeler E, Schwab M, Dilger K, Greinwald R, Mueller R, Stange EF, Herrlinger KR, on behalf of the International AZT-2 Study Group (2010) Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn’s disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial. Gut 59(6):752–759. https://doi.org/10.1136/gut.2009.194159
CAS
Article
PubMed
Google Scholar
Peyrin-Biroulet L, Deltenre P, Ardizzone S, D'Haens G, Hanauer SB, Herfarth H, Lémann M, Colombel JF (2009) Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn’s disease: a meta-analysis. Am J Gastroenterol 104(8):2089–2096. https://doi.org/10.1038/ajg.2009.301
CAS
Article
PubMed
Google Scholar
Regueiro M, Schraut W, Baidoo L, Kip KE, Sepulveda AR, Pesci M, Harrison J, Plevy SE (2009) Infliximab prevents Crohn’s disease recurrence after ileal resection. Gastroenterology 136(2):441–450. https://doi.org/10.1053/j.gastro.2008.10.051
CAS
Article
PubMed
Google Scholar
Regueiro M, Baidoo L, Kip KE et al (2013) Infliximab maintenance beyond one year prevents postoperative Crohn’s disease recurrence: long-term follow-up from the randomized controlled pilot study. Gastroenterology 144(5):S173–S17S
Article
Google Scholar
Yoshida K, Fukunaga K, Ikeuchi H, Kamikozuru K, Hida N, Ohda Y, Yokoyama Y, Iimuro M, Takeda N, Kato K, Kikuyama R, Nagase K, Hori K, Nakamura S, Miwa H, Matsumoto T (2012) Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: a 3-year prospective randomized open trial. Inflamm Bowel Dis 18(9):1617–1623. https://doi.org/10.1002/ibd.21928
Article
PubMed
Google Scholar
Lin J, McKenna BJ, Appelman HD (2010) Morphologic findings in upper gastrointestinal biopsies of patients with ulcerative colitis: a controlled study. Am J Surg Pathol 34:1672–1677. https://doi.org/10.1097/PAS.0b013e3181f3de93
Article
PubMed
Google Scholar
Castellaneta SP, Afzal NA, Greenberg M, Deere H, Davies S, Murch SH, Walker-Smith JA, Thomson M (2004) Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 39(3):257–261. https://doi.org/10.1097/00005176-200409000-00006
CAS
Article
PubMed
Google Scholar
Greuter T, Piller A, Fournier N et al (2018) Upper gastrointestinal tract involvement in Crohn’s disease: frequency, risk factors, and disease course. J Crohns Colitis 12(12):1399–1409. https://doi.org/10.1093/ecco-jcc/jjy121
Article
PubMed
Google Scholar
Oberhuber G, Püspök A, Oesterreicher C et al (1997) Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s disease. Gastroenterology 112(3):698–706. https://doi.org/10.1053/gast.1997.v112.pm9041230
CAS
Article
PubMed
Google Scholar
Wright CL, Riddell RH (1998) Histology of the stomach and duodenum in Crohn’s disease. Am J Surg Pathol 22(4):383–390. https://doi.org/10.1097/00000478-199804000-00001
CAS
Article
PubMed
Google Scholar
Cosnes J, Gower-Rousseau C, Seksik P et al (2011) Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 140:1785–1794. https://doi.org/10.1053/j.gastro.2011.01.055
Article
PubMed
Google Scholar
Levine DS, Haggitt RC (1989) Normal histology of the colon. Am J Surg Pathol 13:966–984. https://doi.org/10.1097/00000478-198911000-00008
CAS
Article
PubMed
Google Scholar
Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW, Kaplan GG (2012) Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142:46–54. https://doi.org/10.1053/j.gastro.2011.10.001
Article
PubMed
Google Scholar
Burisch J, Pedersen N, Cukovic-Cavka S et al (2014) East–west gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort. Gut 63:588–597. https://doi.org/10.1136/gutjnl-2013-304636
CAS
Article
PubMed
Google Scholar
Lakatos L, Kiss LS, David G, Pandur T, Erdelyi Z, Mester G, Balogh M, Szipocs I, Molnar C, Komaromi E, Laszlo Lakatos P (2011) Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002–2006. Inflamm Bowel Dis 17:2558–2265. https://doi.org/10.1002/ibd.21607
Article
PubMed
Google Scholar
Shivananda S, Lennard-Jones J, Logan R, Fear N, Price A, Carpenter L, van Blankenstein M (1996) Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut 39:690–697. https://doi.org/10.1136/gut.39.5.690
CAS
Article
PubMed
PubMed Central
Google Scholar
Björnsson S, Jóhannsson JH (2000) Inflammatory bowel disease in Iceland, 1990–1994: a prospective, nationwide, epidemiological study. Eur J Gastroenterol Hepatol 12:31–38. https://doi.org/10.1080/00365529850166239
Article
PubMed
Google Scholar
Vind L, Riis T, Jess E et al (2006) Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003–2005: a population-based study from the Danish Crohn colitis database. Am J Gastroenterol 101:1274–1282. https://doi.org/10.1111/j.1572-0241.2006.00552.x
Article
PubMed
Google Scholar
Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V (1991) Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. Scand J Gastroenterol 26:1247–1256. https://doi.org/10.3109/00365529108998621
CAS
Article
PubMed
Google Scholar
Moum B, Vatn MH, Ekbom A, Aadland E, Fausa O, Lygren I, Sauar J, Schulz T, Stray N (1996) Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990–93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol 31:362–366. https://doi.org/10.3109/00365529609006411
CAS
Article
PubMed
Google Scholar
Geboes K, Colombel JF, Greenstein A, Jewell DP, Sandborn WJ, Vatn MH, Warren B, Riddell RH, Pathology Task Force of the International Organization of Inflammatory Bowel Diseases (2008) Indeterminate colitis: a review of the concept – what’s in a name? Inflamm Bowel Dis 14:850–857. https://doi.org/10.1002/ibd.20361
Article
PubMed
Google Scholar
Bonetti LR, Manta R, Manno M et al (2018) Optimal processing of ESD specimens to avoid pathological artifacts. Tech Coloproctol 22:857–866. https://doi.org/10.1007/s10151-018-1887-x
Article
Google Scholar
Kim B, Barnett JL, Kleer CG, Appelman HD (1999) Endoscopic and histological patchiness in treated ulcerative colitis. Am J Gastroenterol 94:3258–3262. https://doi.org/10.1111/j.1572-0241.1999.01533.x
CAS
Article
PubMed
Google Scholar
Gramlich T, Petras RE (2007) Pathology of inflammatory bowel disease. Semin Pediatr Surg 16:154–163. https://doi.org/10.1053/j.sempedsurg.2007.04.005
Article
PubMed
Google Scholar
Pai RK, Jairath V, Vande Casteele N, Rieder F, Parker CE, Lauwers GY (2018) The emerging role of histologic disease activity assessment in ulcerative colitis. Gastrointest Endosc 88:887–898. https://doi.org/10.1016/j.gie.2018.08.018
Article
PubMed
Google Scholar
Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Behling C, Kaplan K, Driman DK, Shackelton LM, Baker KA, MacDonald JK, Vandervoort MK, Samaan MA, Geboes K, Valasek MA, Pai R, Langner C, Riddell R, Harpaz N, Sewitch M, Peterson M, Stitt LW, Levesque BG (2014) Reproducibility of histological assessment of disease activity in UC. Gut 64:1–9. https://doi.org/10.1136/gutjnl-2014-307536
Article
Google Scholar
Surawicz CM, Haggitt RC, Husseman M, McFarland LV (1994) Mucosal biopsy diagnosis of colitis: acute self-limited colitis and idiopathic inflammatory bowel disease. Gastroenterology 107:755–763. https://doi.org/10.1016/0016-5085(94)90124-4
CAS
Article
PubMed
Google Scholar
Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, Bastien C, Cahn V, Cadiot G, Diebold MD, Danese S, Reinisch W, Schreiber S, Travis S, Peyrin-Biroulet L (2017) Development and validation of the Nancy histological index for UC. Gut 66:43–49. https://doi.org/10.1136/gutjnl-2015-310187
Article
PubMed
Google Scholar
Rubio CA, Johansson C, Uribe A, Kock Y (1984) A quantitative method of estimating inflammation in the rectal mucosa. IV. Ulcerative colitis in remission. Scand J Gastroenterol 19:525–530
CAS
Article
Google Scholar
Sadik CD, Kim ND, Luster AD (2011) Neutrophils cascading their way to inflammation. Trends Immunol 32:452–460. https://doi.org/10.1016/j.it.2011.06.008
CAS
Article
PubMed
PubMed Central
Google Scholar
Chin AC, Parkos CA (2007) Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury. Annu Rev Pathol 2:111–143. https://doi.org/10.1146/annurev.pathol.2.010506.091944
CAS
Article
PubMed
Google Scholar
Pai RK, Hartman DJ, Rivers CR, Regueiro M, Schwartz M, Binion DG, Pai RK (2019) Complete resolution of mucosal neutrophils associates with improved long-term clinical outcomes of patients with ulcerative colitis. Clin Gastroenterol Hepatol 18(11):2510–2517. https://doi.org/10.1016/j.cgh.2019.12.011
CAS
Article
PubMed
Google Scholar
Mosli MH, Feagan BG, Zou G, Sandborn WJ, D'Haens G, Khanna R, Shackelton LM, Walker CW, Nelson S, Vandervoort MK, Frisbie V, Samaan MA, Jairath V, Driman DK, Geboes K, Valasek MA, Pai RK, Lauwers GY, Riddell R, Stitt LW, Levesque BG (2017) Development and validation of a histological index for UC. Gut 66:50–58. https://doi.org/10.1136/gutjnl-2015-310393
Article
PubMed
Google Scholar
Bressenot A, Salleron J, Bastien C, Danese S, Boulagnon-Rombi C, Peyrin-Biroulet L (2015) Comparing histological activity indexes in UC. Gut 64(9):1412–1418. https://doi.org/10.1136/gutjnl-2014-307477
Article
PubMed
Google Scholar
Feagan BG, Greenberg GR, Wild G, Fedorak RN, Paré P, McDonald JWD, Dubé R, Cohen A, Steinhart AH, Landau S, Aguzzi RA, Fox IH, Vandervoort MK (2005) Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. New Engl J Med 352(4):2499–2507. https://doi.org/10.1056/NEJMoa042982
CAS
Article
PubMed
Google Scholar
Targan SR, Karp LC (2007) Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach. Curr Opin Gastroenterol 23:390–394. https://doi.org/10.1097/MOG.0b013e3281722271
Article
PubMed
Google Scholar
Engel MA, Neurath MF (2010) New pathophysiological insights and modern treatment of IBD. J Gastroenterol 45:571–583. https://doi.org/10.1007/s00535-010-0219-3
CAS
Article
PubMed
Google Scholar
Ng SC, Kamm MA (2009) Therapeutic strategies for the management of ulcerative colitis. Inflamm Bowel Dis 15:935–950. https://doi.org/10.1002/ibd.20797
Article
PubMed
Google Scholar
Christensen B, Erlich J, Gibson PR, Turner JR, Hart J, Rubin DT (2020) Histologic healing is more strongly associated with clinical outcomes in ileal Crohn’s disease than endoscopic healing. Clin Gastroenterol Hepatol 18:2518–2525. https://doi.org/10.1016/jcgh.2020.01.032
Article
PubMed
Google Scholar