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Expression of estrogen and progesterone receptors and inhibin-α in hepatobiliary cystadenoma: an immunohistochemical study

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Abstract

To further characterize the immunohistochemical features of hepatobiliary cystadenoma with mesenchymal stroma, a battery of stains was performed on nine typical cases. All nine tumors had been resected from female patients who ranged in age from 30 to 59 years. Freshly cut sections were stained with antibodies to estrogen receptor (ER), progesterone receptor (PR), α-smooth muscle actin (SMA), inhibin-α, and cytokeratins (CK) 7, 8, 18, and 19. Nuclear staining of the mesenchymal stromal cells for ER and PR was present in all and seven out of nine cases, respectively. A strong cytoplasmic staining of the mesenchymal stromal cells for SMA was seen in all cases. A patchy pale cytoplasmic staining of the tumor epithelium for ER and PR was seen in five out of nine and four out of nine cases, respectively. Immunoreactivity of luteinized stromal cell for inhibin-α was documented in three out of nine cases. All tumors (nine out of nine) demonstrated strong cytoplasmic positivity of the epithelial lining of the cysts to CK7, CK8, CK18, and CK19, typical of biliary-type epithelium. The expression of ER, PR, and inhibin-α in the ovarian-like stroma supports the likely hormonal dependence of this tumor and probably explains its almost exclusive occurrence in women.

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Authors and Affiliations

  1. Division of Hepatic Pathology, Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306-6000, USA

    Hala M. Abdul-Al, Hala R. Makhlouf & Zachary D. Goodman

  2. Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306-6000, USA

    Hala M. Abdul-Al, Hala R. Makhlouf & Zachary D. Goodman

Authors
  1. Hala M. Abdul-Al
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  2. Hala R. Makhlouf
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  3. Zachary D. Goodman
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Correspondence to Hala M. Abdul-Al.

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The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense.

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Abdul-Al, H.M., Makhlouf, H.R. & Goodman, Z.D. Expression of estrogen and progesterone receptors and inhibin-α in hepatobiliary cystadenoma: an immunohistochemical study. Virchows Arch 450, 691–697 (2007). https://doi.org/10.1007/s00428-007-0411-x

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  • DOI: https://doi.org/10.1007/s00428-007-0411-x

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