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Genomic analysis of a case of multifocal adenocarcinoma in ulcerative colitis

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Abstract

Long-standing ulcerative colitis is associated with an elevated risk of developing colonic adenocarcinoma. A very limited group of patients present with multiple synchronous cancers. This could be due to either a multifocal presentation of the same neoplastic clone or different tumors arising in a large area of polyclonal dysplastic colonic mucosa (“field cancerization”). Here, we describe a patient with long-standing colitis and three different tumors in the rectosigmoid part of the large bowel. Clonal evaluation of the lesions was performed by array-based comparative genomic hybridization. These three neoplasms showed a comparable pattern of genomic alterations characterized by gains of chromosomes 12, 13, and 20. Noteworthy, dysplastic mucosa distal to the three cancers displayed a completely different pattern of genomic changes indicating that different cell lineages were present. In addition, all three carcinomas were microsatellite stable and revealed identical immunoprofiles for several cancer-associated genes. We conclude that these three multifocal tumors must have originated from the same preneoplastic lineage.

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Authors and Affiliations

  1. Department of Pathology, Erasmus Medical Center, Josephine Nefkens Institute, Dr. Molewaterplein 50, 3015GE, Rotterdam, The Netherlands

    Herman van Dekken, Josiane C. Wink, Kees J. Vissers, Ronald van Marion, Patrick F. Franken, Monique M. C. P. Hoogmans & Winand N. M. Dinjens

  2. Department of Surgery, Erasmus Medical Center, Josephine Nefkens Institute, Dr. Molewaterplein 50, 3015GE, Rotterdam, The Netherlands

    W. Ruud Schouten

  3. Department of Gastroenterology and Hepatology, Erasmus Medical Center, Josephine Nefkens Institute, Dr. Molewaterplein 50, 3015GE, Rotterdam, The Netherlands

    Ernst J. Kuipers & C. Janneke van der Woude

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  1. Herman van Dekken
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  2. Josiane C. Wink
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  3. Kees J. Vissers
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  4. Ronald van Marion
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  5. Patrick F. Franken
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  6. Monique M. C. P. Hoogmans
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  7. Winand N. M. Dinjens
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  8. W. Ruud Schouten
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  9. Ernst J. Kuipers
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  10. C. Janneke van der Woude
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Correspondence to Herman van Dekken.

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van Dekken, H., Wink, J.C., Vissers, K.J. et al. Genomic analysis of a case of multifocal adenocarcinoma in ulcerative colitis. Virchows Arch 449, 716–721 (2006). https://doi.org/10.1007/s00428-006-0312-4

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  • DOI: https://doi.org/10.1007/s00428-006-0312-4

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