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Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma

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Abstract

Reduction/loss of E-cadherin is associated with the development and progression of many epithelial tumors, while in a limited number of neoplasms, E-cadherin is re-expressed in metastases. Dysadherin, recently characterized by members of our research team, has an anti-cell–cell adhesion function and downregulates E-cadherin in a posttranscriptional manner. Colorectal cancer (CRC) is one of the most common tumors in the developed world, and lymph node metastases are harbingers of aggressive behavior. The aim of the present study was to examine the dysadherin and E-cadherin expression patterns in lymph node metastases vs primary CRC. Dysadherin and E-cadherin expression was examined immunohistochemically in 78 patients with CRC, Dukes’ stage C in the primary tumor and in one lymph node metastasis. Dysadherin was expressed in 42% while E-cadherin immunoreactivity was reduced in 45% of primary tumors. In lymph nodes, 33 and 81% of metastatic tumors were positive for dysadherin and E-cadherin, respectively. Dysadherin expression was not correlated with E-cadherin expression in the primary tumor with a reverse correlation evident in the lymph node metastases. Our results suggest that different mechanisms govern E-cadherin expression in the primary tumor and the corresponding lymph node metastases.

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Authors and Affiliations

  1. Department of Pathology, University of Ioannina Medical School, University Campus, P.O. Box 1186, 451 10, Ioannina, Greece

    Anna Batistatou & Niki J. Agnantis

  2. Department of Surgery, Peterborough and Stamford Hospitals, Cambridgeshire, UK

    Alexander K. Charalabopoulos

  3. Department of Surgery, University of Ioannina Medical School, Ioannina, Greece

    Alexander K. Charalabopoulos & Angelos Kappas

  4. Department of Pathology, University of Patras Medical School, Patras, Greece

    Chrisoula D. Scopa

  5. Pathology Division, National Cancer Center Research Institute, Tokyo, Japan

    Yukihiro Nakanishi & Setsuo Hirohashi

  6. Department of Physiology, Clinical Unit, University of Ioannina Medical School, Ioannina, Greece

    Konstantinos Charalabopoulos

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  1. Anna Batistatou
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  2. Alexander K. Charalabopoulos
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  3. Chrisoula D. Scopa
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  4. Yukihiro Nakanishi
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  6. Setsuo Hirohashi
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Correspondence to Anna Batistatou.

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Batistatou, A., Charalabopoulos, A.K., Scopa, C.D. et al. Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma. Virchows Arch 448, 763–767 (2006). https://doi.org/10.1007/s00428-006-0183-8

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  • DOI: https://doi.org/10.1007/s00428-006-0183-8

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