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Characteristics of Epstein-Barr virus associated childhood non-Hodgkin’s lymphoma in the Republic of Korea

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Abstract

To analyze the clinicopathologic characteristics of childhood non-Hodgkin’s lymphoma (NHL) associated with Epstein-Barr virus (EBV), EBER in situ hybridization was performed in 80 cases of NHLs. EBER-positive lymphomas account for 25% (20/80) and include NK/T-cell lymphoma (6/6), aggressive NK-cell leukemia (1/1), peripheral T cell lymphoma (5/11), diffuse large B-cell lymphoma (5/14), hydroa-like T-cell lymphoma (1/1), marginal zone B-cell lymphoma (1/2), and post-transplantation lymphoproliferative disorder (1/1). Other types including 19 cases of Burkitt’s lymphoma were negative. For 9 EBER-positive cases, immunohistochemical staining for LMP-1, and EBNA-2 was performed to determine the EBV latency pattern. Two of nine EBER-positive cases expressed both LMP-1 and EBNA-2. Clinically, patients with EBV-positive B-cell lymphomas were cured with chemotherapy, whereas EBV-associated NK- and T cell lymphomas pursued fatal clinical course. In conclusion, EBVs infected in childhood NHLs are frequently associated not only with NK- and T- cell lymphomas but also large B-cell lymphomas.

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Authors and Affiliations

  1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-gu, Ilwon-dong 50, 135-710, Seoul, South Korea

    DongHoon Kim, YoungHyeh Ko & Yeonlim Suh

  2. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-gu, Ilwon-dong 50, 135-710, Seoul, South Korea

    HongHoe Koo

  3. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Pungnap-dong 388-1, 138-736, Seoul, South Korea

    JooRyung Huh

  4. Department of Biological Science, Myongji University, Yongin-si, Namdong, 449-728, Kyunggi-do, South Korea

    WonKeun Lee

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  1. DongHoon Kim
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  2. YoungHyeh Ko
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  3. Yeonlim Suh
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  4. HongHoe Koo
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  5. JooRyung Huh
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Correspondence to YoungHyeh Ko.

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Kim, D., Ko, Y., Suh, Y. et al. Characteristics of Epstein-Barr virus associated childhood non-Hodgkin’s lymphoma in the Republic of Korea. Virchows Arch 447, 593–596 (2005). https://doi.org/10.1007/s00428-005-1277-4

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  • DOI: https://doi.org/10.1007/s00428-005-1277-4

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