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The T-type calcium channelosome

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Pflügers Archiv - European Journal of Physiology Aims and scope Submit manuscript

Abstract

T-type calcium channels perform crucial physiological roles across a wide spectrum of tissues, spanning both neuronal and non-neuronal system. For instance, they serve as pivotal regulators of neuronal excitability, contribute to cardiac pacemaking, and mediate the secretion of hormones. These functions significantly hinge upon the intricate interplay of T-type channels with interacting proteins that modulate their expression and function at the plasma membrane. In this review, we offer a panoramic exploration of the current knowledge surrounding these T-type channel interactors, and spotlight certain aspects of their potential for drug-based therapeutic intervention.

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Data availability

All data generated or analyzed during this study are included in this published article.

Abbreviations

ANKB:

Ankyrin B

CACHD1:

Ca2+ channel and chemotaxis receptor (cache) domain-containing protein 1

CaM:

Calmodulin

CAV-3:

Caveolin-3

CNX:

Calnexin

ENaC:

Epithelial sodium channel

KLHL1:

Kelch-like protein 1

RACK1:

Receptor for activated C kinase 1

SCAMP2:

Secretory carrier-associated membrane protein 2

SCAMP5:

Secretory carrier-associated membrane protein 2

SPTA/B:

Spectrin A/B

STAC1:

SH3 and cysteine-rich domain-containing protein 1

STX1A:

Syntaxin 1A

USP5:

Ubiquitin specific peptidase 1

WWP1/2:

WW domain-containing E3 ubiquitin protein ligase 1/2

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Funding

N.W. is supported by a grant from the Czech Science Foundation (GACR #22-23242S) and the National Institute for Research of Metabolic and Cardiovascular Diseases (Program EXCELES # LX22NPO5104), funded by the European Union–Next Generation EU. G.W.Z. is funded by the Canadian Institutes of Health Research and holds a Canada Research Chair.

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  1. Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic

    Norbert Weiss

  2. Department of Clinical Neurosciences, Alberta Children’s Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada

    Gerald W. Zamponi

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Weiss, N., Zamponi, G.W. The T-type calcium channelosome. Pflugers Arch - Eur J Physiol 476, 163–177 (2024). https://doi.org/10.1007/s00424-023-02891-z

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