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Oxygen physiology: sensors and ion channels

  • Yasuo Mori
  • Nobuaki Takahashi
  • Nozomi Ogawa
  • Thomas Gudermann
Open Access
Invited Review

Keywords

Glomus Cell Hematopoietic Stem Cell Niche High Altitude Hypoxia Reactive Chemical Species Cycle Quiescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Ever since Pflüger, it has been always a major issue of physiology to identify the core principles underlying our body’s ability to sense and adapt to the changes in the availability of ambient molecular oxygen (O2) [3, 5]. The milestone discovery of an O2 sensor was first achieved at the organ level by Heymans, who demonstrated that inspired hypoxia triggers increased breathing through the stimulation of the carotid bodies (CBs) [2]. With regard to the cellular and molecular mechanisms underlying the acute hypoxia-sensing in the CBs, it is generally accepted that hypoxia inhibits K+ channels to depolarize the chemoreceptor glomus cells, leading to the activation of voltage-dependent Ca2+ channels and consequent release of neurotransmitters that relays information to regulate the respiration [10]. Another milestone is the discovery of a soluble factor erythropoietin (Epo) that is essential for the chronic phases of O2 adaptation. At the end of nineteenth century, it was recognized by Viault that exposure to high altitude hypoxia elicits a robust burst of erythropoiesis in humans [1]. Almost a half century later, Epo was demonstrated to mediate hypoxia-induced erythropoiesis. While the initial characterizations of the expression of Epo suggested its production in the fetal liver and adult kidney, it was only recently that the localization of the renal Epo-producing (REP) cell was found to be in the peritubular interstitial space located in the deep renal outer medulla region [4]. In addition, hypoxia-inducible factor (HIF) [6] is recognized as the transcription factor central to chronic cellular responses to hypoxia including erythropoiesis via Epo production. Thus, CBs, Epo, and HIF provide solid bases for understanding the body’s ability to sense and adapt to the ambient O2.

Even after the above discoveries of the core principles, the physiology of O2 sensing and adaptation never loses its glory. This is highlighted by recent findings concerning the diversity and ubiquity of O2-sensing mechanisms. For example, in addition to multiple K+ channel subtypes and mediators previously reported responsible for hypoxia sensing, transient receptor potential (TRP) cation channels have emerged as O2–regulated ion channels critical for O2 sensing in non-CB chemoreceptors and tissues [7, 11]. Importantly, HIF, which binds to the hypoxia-responsive element present in the 3′ enhancer region of the Epo gene [6], is expressed widely throughout the body and is intriguingly found in lower organisms that produce neither Epo nor red blood cells. In addition to erythropoiesis, chronic hypoxia induces the expression of numerous genes whose products facilitate non-oxidative synthesis of ATP and multiply the number of vessels supplying the hypoxic area of tissues [8] through the action of HIFs. These lines of evidence suggest the ubiquitous presence of O2-sensing cells and organs in the animal body. In this context, it is interesting to note that two HIF isoforms HIF1 and HIF2 play distinctive roles in the regulation of hypoxic responses of CBs by differentially promoting cellular redox status [12]. Moreover, the physiological importance of hypoxia has been demonstrated in maintaining the hematopoietic stem cell niche for cell cycle quiescence through the action of HIF in the bone marrow [9]. In this special issue, reviews of these recent developments are included together with several important original research articles, which indeed enrich our knowledge in O2 physiology.

We believe that there is a great prospect that O2 physiology will further enhance its current status as a major issue in physiology. A future direction of O2 physiology is systems physiology, in which regulation of O2 sensing and adaptation through interplays among different chemoreceptors and molecules are studied. Another possible direction is to understand O2 sensing and adaptation in the context of redox biology, where alterations in redox homeostasis (via reactive chemical species and antioxidant systems) in response to changes in the O2 availability are integrated with other types of stress such as metabolic perturbation, heat, and proinflammatory mediators. Adding these future developments to O2 physiology should lead us to understand our body’s ability as a total system to adapt to changes in ambient O2 availability.

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Copyright information

© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Yasuo Mori
    • 1
    • 2
  • Nobuaki Takahashi
    • 1
    • 3
  • Nozomi Ogawa
    • 1
  • Thomas Gudermann
    • 4
    • 5
    • 6
  1. 1.Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of EngineeringKyoto UniversityKyotoJapan
  2. 2.Laboratory of Environmental Systems Biology, Department of Technology and Ecology, Hall of Global Environmental StudiesKyoto UniversityKyotoJapan
  3. 3.Department of Cell BiologyHarvard Medical SchoolBostonUSA
  4. 4.Walther-Straub-Institute for Pharmacology and ToxicologyLudwig-Maximilians UniversityMunichGermany
  5. 5.Comprehensive Pneumology Center Munich (CPC-M)German Center for Lung ResearchMunichGermany
  6. 6.DZHK (German Centre for Cardiovascular Research)Munich Heart AllianceMunichGermany

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