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Reduction of perioperative venous thrombus formation by antithrombotic peripherally inserted central catheter in esophageal cancer

  • Original Article
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Abstract

Purpose

Although a central venous catheter (CVC) is often needed perioperatively for intraoperative and nutritional management of esophageal cancer (EC), the catheter placement impacts the risk of venous thrombosis. We examined the risks of thrombus formation by catheter type, placement, and duration.

Methods

In total, 226 patients with EC were enrolled in this retrospective study. Patients were classified into one of three groups: those with a conventional CVC (cCVC), a peripherally inserted central catheter (PICC), or an antithrombogenic agent-coated PICC (secPICC). The thrombus formation and clinicopathological features were examined.

Results

The frequency of all types of thrombosis was significantly lower in the secPICC group (p < 0.01). Although deep vein thrombosis was frequent in the cCVC group, catheter thrombosis was frequent in the PICC group. In a univariate analysis in patients with the PICC and secPICC groups, less thrombus formation was observed in the secPICC (p = 0.01), short placement time (p = 0.02), and right-sided placement (p < 0.01). Furthermore, a multivariate analysis revealed that secPICC (p = 0.049) and right-sided placement (p = 0.04) significantly reduced rates of thrombus formation.

Conclusion

In patients with EC, secPICC and right-sided placement reduce perioperative venous thrombus formation.

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Acknowledgements

We thank Enago (www.enago.jp) for the English language review.

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Authors and Affiliations

  1. Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan

    Kenji Nanishi, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Takuma Ohashi, Hiroki Shimizu, Tomohiro Arita, Takeshi Kubota, Kazuma Okamoto & Eigo Otsuji

Authors
  1. Kenji Nanishi
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  2. Hirotaka Konishi
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  3. Atsushi Shiozaki
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  4. Hitoshi Fujiwara
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  5. Takuma Ohashi
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  6. Hiroki Shimizu
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  7. Tomohiro Arita
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  9. Kazuma Okamoto
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  10. Eigo Otsuji
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Contributions

This study was designed by KN, TK, and EO; KN and HK performed statistical analyses. The clinical information and materials were collected and kept by KN, HK, TO, HS, TA, AS, TK, HF, KO, and EO; KN and HK drafted the manuscript. TO, HS, TA, AS, TK, HF, KO, and EO edited and revised the manuscript. KN, HK, TO, HS, TA, AS, TK, HF, KO, and EO approved the final version of the manuscript. KN, HK, TO, HS, TA, AS, TK, HF, KO, and EO agreed to be accountable for all aspects of the work.

Corresponding author

Correspondence to Hirotaka Konishi.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Nanishi, K., Konishi, H., Shiozaki, A. et al. Reduction of perioperative venous thrombus formation by antithrombotic peripherally inserted central catheter in esophageal cancer. Langenbecks Arch Surg 407, 1009–1016 (2022). https://doi.org/10.1007/s00423-021-02367-7

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  • DOI: https://doi.org/10.1007/s00423-021-02367-7

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