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Perineural invasion and number of retrieved lymph nodes are prognostic factors for T2N0 colon cancer

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Abstract

Purpose

The prognosis of pathological T2N0 colon cancer has not been adequately investigated. This study aimed to determine the prognostic factors for pathological T2N0 colon cancer by comparing it with those for pathological T3N0 colon cancer.

Methods

We retrospectively reviewed patients with primary colon cancer who underwent curative resection between January 2007 and December 2015 and included 889 patients with postoperative pathological T2-3N0M0 disease. The clinicopathological characteristics were analyzed to identify the independent prognostic factors.

Results

Pathological T2 (n = 185, 20.8%) and T3 (n = 704, 79.2%) tumors showed no difference in the 5-year disease-free survival (5Y DFS) rate (95.8% vs. 93.2%, p = 0.257) after a median follow-up of 55 months (range, 1–106 months). Multivariate Cox regression analysis showed that perineural invasion (hazard ratio [HR] = 2.041, 95% confidence interval [CI] 1.122–3.712, p = 0.019) and number of retrieved lymph nodes < 12 (HR = 2.994, 95% CI 1.327–6.753, p = 0.008) were independent prognostic factors for DFS. Pathological T2 tumors with poor prognostic factors showed similar 5Y DFS as that of T3 tumors with poor prognostic factors (88.9% vs. 88.6%, p = 0.916), but not with T3 tumors without poor prognostic factors (88.9% vs. 95.0%, p = 0.089).

Conclusion

Pathological T2N0 colon cancer showed oncologic outcomes similar to that of T3N0 colon cancer. Therefore, more intensive surveillance is necessary for patients with high-risk T2N0 colon cancer.

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Acknowledgements

The abstract of this article was presented at the 53rd Annual Meeting of the Korean Society of Coloproctology in Korea on September 5–6, 2020.

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Authors and Affiliations

  1. Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 322 Seoyang-ro Hwasun-eup, Hwasun-gun, Jeonnam, 58128, Korea

    Soo Young Lee, Jaram Lee, Hyeong-min Park, Chang Hyun Kim & Hyeong Rok Kim

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  1. Soo Young Lee
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  2. Jaram Lee
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Correspondence to Hyeong Rok Kim.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was exempted because of the retrospective study design, and because the results contained no personal data. It was approved by the Institutional Review Board of our institution.

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Lee, S.Y., Lee, J., Park, Hm. et al. Perineural invasion and number of retrieved lymph nodes are prognostic factors for T2N0 colon cancer. Langenbecks Arch Surg 406, 1979–1985 (2021). https://doi.org/10.1007/s00423-021-02172-2

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  • DOI: https://doi.org/10.1007/s00423-021-02172-2

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