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From the genome to the proteome—biomarkers in colorectal cancer

  • New Surgical Horizons
  • Published:
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Abstract

Background and aims

Colorectal cancer is the second leading cause of cancer-related death. Current clinical practice in colorectal cancer screening (fecal occult blood test, FOBT; colonoscopy) has contributed to a reduction of mortality. However, despite these screening programs, about 70% of carcinomas are detected at advanced tumor stages (UICC III/IV) presenting poor patient prognosis. Thus, innovative tools and methodologies for early cancer detection can directly result in improving patient survival rates.

Patients/methods

Biomedical research has advanced rapidly in recent years with the availability of technologies such as global gene and protein expression profiling. Comprehensive tumor profiling has become a field of intensive research aiming at identifying biomarkers relevant for improved diagnostics and therapeutics.

Results

In this paper, we report a comprehensive review of genomic, transcriptomic, and proteomic approaches for biomarker identification in tissue and blood with a main emphasis on two-dimensional gel-electrophoresis (2-DE) and mass spectrometry analyses.

Conclusion

Proteomics-based technologies enable to distinguish the healthy patient from the tumor patient with high sensitivity and specificity and could greatly improve common classification systems and diagnostics. However, this progress has not yet been transferred from bench to bedside but could open the door to a more accurate and target specific personalized medicine with improved patient survival.

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Authors and Affiliations

  1. Department of Surgery, University of Schleswig—Holstein Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Jens K. Habermann, Franz G. Bader, Christian Franke, Kaja Zimmermann, Timo Gemoll, Britta Fritzsche, Hans-Peter Bruch & Uwe J. Roblick

  2. Karolinska Biomic Center (KBC), Karolinska Institutet, 17176, Stockholm, Sweden

    Franz G. Bader & Gert Auer

  3. Genetics Branch, National Cancer Institute, NIH, 50 South Drive, Bethesda, MD, 20892, USA

    Thomas Ried

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  1. Jens K. Habermann
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Habermann, J.K., Bader, F.G., Franke, C. et al. From the genome to the proteome—biomarkers in colorectal cancer. Langenbecks Arch Surg 393, 93–104 (2008). https://doi.org/10.1007/s00423-007-0230-1

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