Correction to: Molecular regulation of skeletal muscle mitochondrial biogenesis following blood flow-restricted aerobic exercise: a call to action

Correction to: European Journal of Applied Physiology https://doi.org/10.1007/s00421-021-04669-6

The original version of this article unfortunately contained a mistake. There is an error in Fig. 1.

The correct version of Fig. 1 is given in the following page.

Fig. 1

a Regulation of peroxisome proliferator-activated gamma coactivator 1-alpha (PGC-1α). Straight dashed arrow on the right side of the figure represents the autoregulation of PGC-1α. b Speculated effects of BFR-induced ischemia on peroxisome proliferator-activated gamma coactivator 1-alpha (PGC-1α) expression via increased [AMP]:[ATP] ratio. Decreased local oxygen availability from reduced arterial blood flow leads to increased reduction of the electron transport chain (ETC). As a result, less H⁺ is pumped to the intermembrane space of the mitochondria, leading to a smaller electrochemical gradient across the ETC. ATP synthase thus phosphorylates less ADP, increasing [AMP] and [ADP]. Increased [ADP] and [AMP] stimulates the rate-limiting enzyme of glycolysis, phosphofructokinase-1 (PFK), and more pyruvate is produced. Given that the capacity for glycolytic flux is greater than the capacity for pyruvate dehydrogenase to oxidise pyruvate to acetyl-CoA (Spriet et al. 2000), the law of mass action dictates more pyruvate reducing to lactate. Importantly, increased [AMP] also activates AMPK, which subsequently phosphorylates and activates PGC-1α. AMPK 5′ AMP-activated protein kinase, ATP adenosine triphosphate, ß-AR beta-2 adrenergic receptor, Ca²⁺ calcium ions, CaMKII calmoldulin-dependent protein kinase II, cAMP cyclic adenosine monophosphate, cGMP cyclic guanosine monophosphate, Epi epinephrine, ERR oestrogen-related receptors, LDH lactate dehydrogenase, LKB1 liver kinase B1, MEF2 myocyte enhancer factor-2, NADH/NAD⁺ nicotinamide adenine dinucleotide, NAMPT nicotinamide phosphoribosyltransferase, NE norepinephrine, NEMP nuclear-encoded mitochondrial proteins, NO nitric oxide, NRF nuclear respiratory factors, p38 MAPK p38 mitogen-activated protein kinase, PDH pyruvate dehydrogenase, PFK phosphofructokinase, PKA protein kinase A, PPAR peroxisome proliferator-activated receptor, RNS reactive nitrogen species, ROS reactive oxygen species, SIRT1 silent mating-type information regulation 2 homolog 1, TFAM mitochondrial transcription factor A

The original article has been corrected.