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Continuous cardiac autonomic and haemodynamic responses to isometric exercise in females

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Abstract

Purpose

Hypertension is associated with impaired haemodynamic control mechanisms and autonomic dysfunction. Isometric exercise (IE) interventions have been shown to improve autonomic modulation and reduce blood pressure (BP) predominantly in male participants. The physiological responses to IE are unexplored in female populations; therefore, this study investigated the continous cardiac autonomic and haemodynamic response to a single bout of IE in a large female population.

Methods

Forty physically inactive females performed a single, individually prescribed isometric wall squat training session. Total power spectral density of heart rate variability (HRV) and associated low-frequency (LF) and high-frequency (HF) power spectral components were recorded in absolute (ms2) and normalised units (nu) pre, during and post an IE session. Heart rate (HR) was recorded via electrocardiography and baroreceptor reflex sensitivity (BRS) via the sequence method. Continuous blood pressure was recorded via the vascular unloading technique and stroke volume via impedance cardiography. Total peripheral resistance (TPR) was calculated according to Ohm’s law.

Results

During IE, there were significant reductions in HRV (p < 0.001) and BRS (p < 0.001), and significant increases in heart rate (p < 0.001), systolic, mean and diastolic BP (p < 0.001 for all). In recovery following the IE session, cardiac autonomic parameters returned to baseline (p = 0.974); however, total peripheral vascular resistance significantly reduced below baseline (p < 0.001). This peripheral vascular response was associated with significant reductions in systolic (−17.3 ± 16.5 mmHg, p < 0.001), mean (−18.8 ± 17.4 mmHg, p < 0.001) and diastolic BP (−17.3 ± 16.2 mmHg, p < 0.001), below baseline.

Conclusion

A single IE session is associated with improved haemodynamic cardiovascular responses in females. Cardiac autonomic responses return to baseline values, which suggests that alternative mechanisms are responsible for the post-exercise haemodynamic improvements in females. Future mechanistic research is required to investigate the acute and chronic effects of IE in female populations with different resting BP profiles.

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Abbreviations

BEI:

Baroreceptor effectiveness index

BP:

Blood pressure

BRS:

Baroreceptor reflex sensitivity

dBP:

Diastolic blood pressure

HF:

High frequency

HR:

Heart rate

HRV:

Heart rate variability

IE:

Isometric exercise

IET:

Isometric exercise training

LF:

Low frequency

mBP:

Mean blood pressure

Q̇:

Cardiac output

sBP:

Systolic blood pressure

SV:

Stroke volume

TPR:

Total peripheral resistance

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Authors and Affiliations

  1. School of Human and Life Sciences, Canterbury Christ Church University, Kent, CT1 1QU, England

    Jamie M. O’Driscoll, Claire Boucher, Meliz Vilda, Katrina A. Taylor & Jonathan D. Wiles

Authors
  1. Jamie M. O’Driscoll
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  2. Claire Boucher
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  3. Meliz Vilda
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  4. Katrina A. Taylor
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  5. Jonathan D. Wiles
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Contributions

J.O’D, C.B, M.V., K.A.T, and J.D.W did conception and design of research; J.O’D, C.B, M.V., and K.A.T performed the experiments; J.O’D, C.B, M.V., and K.A.T. analysed the data; J.O’D, C.B, M.V., K.A.T, and J.D.W. interpreted the results of experiments; J.O’D prepared the figures; J.O’D, C.B, M.V., K.A.T, and J.D.W. drafted the manuscript; J.O’D, C.B, M.V., K.A.T, and J.D.W. edited and revised the manuscript; J.O’D, C.B, M.V., K.A.T, and J.D.W. approved the final version of manuscript.

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Correspondence to Jamie M. O’Driscoll.

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Communicated by I. Mark Olfert.

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O’Driscoll, J.M., Boucher, C., Vilda, M. et al. Continuous cardiac autonomic and haemodynamic responses to isometric exercise in females. Eur J Appl Physiol 121, 319–329 (2021). https://doi.org/10.1007/s00421-020-04525-z

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