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Endurance training enhances ABCA1 expression in rat small intestine

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Abstract

The purpose of this study was to investigate liver and intestinal ABCA1 expression and plasma HDL-C level in response to treadmill-running training in rats. Twenty adult Wistar male rats (17–18 weeks old, 300–322 g) were divided into control (n = 10) and Training (n = 10) groups. Training group trained at 25 m/min (0% grade) for 60 min/day, 5 days/week for 12 weeks. Rats were killed 48 h after the last session of training. The intestinal and liver ABCA1 mRNA expression was found to be significantly higher in trained compared to control group (P < 0.006 and P < 0.024, respectively). Intestine and liver ATP concentrations remained unchanged. Plasma HDL-C, HDL2-C, Apo A-1, pre-β HDL-C concentration, LCAT activity, TC/HDL-C and LDL-C/HDL-C ratio significantly increased in trained group (P < 0.01, P < 0.006, P < 0.001, P < 0.001 P < 0.067, P < 0.02, and P < 0.03, respectively). However, other lipoprotein concentrations were unchanged. In conclusion, we found that endurance training induced significant elevation in plasma HDL-C and HDL2-C concentrations, accompanied by higher plasma Apo A-1, pre-β HDL-C concentrations, LCAT activity and ABCA1 mRNA expressions in rat intestine, and liver.

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Acknowledgments

We wish to thank Professor Dimitri Sviridov for their helpful comments and guides.

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Authors and Affiliations

  1. Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran

    Behzad Mehdi Khabazian

  2. Department of Physical Education and Sports Sciences, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran

    Abbass Ghanbari-Niaki

  3. Department of Physical Education and Sports Sciences, Faculty of Humanity, Tarbiat Modares University, Tehran, Iran

    Ali reza Safarzadeh-Golpordesari & Mehdi Ebrahimi

  4. Department of Biotechnology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Fatemeh Rahbarizadeh

  5. Faculty of Physical Education and Sports Science, Tarbiat Moallem University, Tehran, Iran

    Hossein Abednazari

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  1. Behzad Mehdi Khabazian
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  2. Abbass Ghanbari-Niaki
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  3. Ali reza Safarzadeh-Golpordesari
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  4. Mehdi Ebrahimi
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  5. Fatemeh Rahbarizadeh
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  6. Hossein Abednazari
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Correspondence to Behzad Mehdi Khabazian or Abbass Ghanbari-Niaki.

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Khabazian, B.M., Ghanbari-Niaki, A., Safarzadeh-Golpordesari, A.r. et al. Endurance training enhances ABCA1 expression in rat small intestine. Eur J Appl Physiol 107, 351–358 (2009). https://doi.org/10.1007/s00421-009-1133-3

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