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Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats

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Abstract

Myocardial infarction (MI) has been associated with increases in reactive oxygen species (ROS). Exercise training (ET) has been shown to exert positive modulations on vascular function and the purpose of the present study was to investigate the effect of moderate ET on the aortic superoxide production index, NAD(P)H oxidase activity, superoxide dismutase activity and vasomotor response in MI rats. Aerobic ET was performed during 11 weeks. Myocardial infarction significantly diminished maximal exercise capacity, and increased vasoconstrictory response to norepinephrine, which was related to the increased activity of NAD(P)H oxidase and basal superoxide production. On the other hand, ET normalized the superoxide production mostly due to decreased NAD(P)H oxidase activity, although a minor SOD effect may also be present. These adaptations were paralleled by normalization in the vasoconstrictory response to norepinephrine. Thus, diminished ROS production seems to be an important mechanism by which ET mediates its beneficial vascular effects in the MI condition.

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Acknowledgments

We gratefully acknowledge the scientific and technical support provided by Dr. Francisco Rafael Martins Laurindo and his research group (Laboratory of Vascular Biology, InCor-HCFMUSP).

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Authors and Affiliations

  1. Laboratory of Biochemistry of Exercise, School of Physical Education and Sport, University of São Paulo, Av. Prof. Mello Moraes, 65, São Paulo, SP, 05508-900, Brazil

    Nelo Eidy Zanchi, Luiz Roberto Grassmann Bechara, Leonardo Yuji Tanaka, Teresa Bartholomeu & Paulo Rizzo Ramires

  2. Heart Institute (InCor), Medical School, University of São Paulo, São Paulo, Brazil

    Victor Debbas

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  1. Nelo Eidy Zanchi
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  2. Luiz Roberto Grassmann Bechara
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  3. Leonardo Yuji Tanaka
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  5. Teresa Bartholomeu
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  6. Paulo Rizzo Ramires
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Correspondence to Paulo Rizzo Ramires.

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Zanchi, N.E., Bechara, L.R.G., Tanaka, L.Y. et al. Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats. Eur J Appl Physiol 104, 1045–1052 (2008). https://doi.org/10.1007/s00421-008-0861-0

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