Abstract
Objectives
To assess the extent of exposure to lead, cadmium, and mercury in the Korean general adult population using a representative sample.
Methods
We studied blood concentrations of three heavy metals in a representative sample of 1,997 Koreans as part of the Third Korean National Health and Nutrition Examination Survey (KNHANES III) performed in 2005.
Results
The geometric means of the blood lead, cadmium, and mercury concentrations were 2.61 μg/dL, 1.53 μg/L, and 4.15 μg/L, respectively [95% confidence intervals (CIs), 2.50–2.71, 1.48–1.58, and 3.94–4.36, respectively]. Women had significantly lower blood lead and mercury concentrations in adjusted and unadjusted analyses but no difference between genders was observed in blood cadmium analysis. The geometric means of blood lead and mercury levels were higher in subjects older than 40 years than in those younger than 40 years. Smoking status only affected the blood lead concentration, with this being higher in smokers than in nonsmokers. Blood cadmium levels did not differ with demographic and lifestyle variables after covariate adjustment. Blood mercury concentrations were higher in those who consumed alcohol and also increased with the frequency of fish consumption.
Conclusions
This biomonitoring study of blood heavy metals in the Korean general population as part of KNHANES III provides important reference data stratified by demographic and lifestyle factors that will be useful for the ongoing surveillance of environmental exposure of the Korean general population to heavy metals.
Similar content being viewed by others
References
Ask K, Akesson A, Berglund M, Vahter M (2002) Inorganic mercury and methylmercury in placentas of Swedish women. Environ Health Perspect 110:523–526
Batariova A, Spevackova V, Benes B, Cejchanova M, Smid J, Cerna M (2006) Blood and urine levels of Pb, Cd and Hg in the general population of the Czech Republic and proposed reference values. Ind J Hyg Environ Health 209:359–366
Becker K, Kaus S, Krause C, Lepom P, Schulz C, Seiwert M, Seifert B (2002) German Environmental Survey 1988 (GerES III): environmental pollutants in blood of the German population. Int J Hyg Environ Health 205:297–308
Berglund M, Akesson A, Nermell B, Vahter M (1994) Intestinal absorption of dietary cadmium in women depends on body iron stores and fiber intake. Environ Health Perspect 102:1058–1066
Berode M, Wietlisbach V, Richenback M, Guillemin MP (1991) Lifestyle and environmental factors as determinants of blood lead levels in a Swiss population. Environ Res 55:1–17
Bjornberg KA, Vahter M, Grawe KP, Berglund M (2005) Methyl mercury exposure in Swedish women with high fish consumption. Sci Total Environ 341:45–52
Glass DC, Gray CN (2001) Estimating mean exposure from censored data: exposure to benzene in the Australian petroleum industry. Ann Occup Hyg 45:275–282
Guallar E, Silbergeld EK, Navas-Acien A, Malhotra S, Astor BC, Sharrett AR, Schwartz BS (2006) Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal function. Am J Epidemiol 163:700–708
Hightower JM, OHara A, Hernandez GT (2006) Blood mercury reporting in NHANES: identifying Asian, Pacific Islander, Native American, and multiracial groups. Environ Health Perspect 114:173–175
Hsu CS, Liu PL, Chien LC, Chou SY, Han BC (2007) Mercury concentration and fish consumption in Taiwanese pregnant women. BJOG 114:81–85
Ikeda M, Moon C-S, Shimbo S, Watanabe T (1994) Dietary cadmium intake among Japanese people: annual trends and regional difference. Jpn J Hyg 49:176
Ikeda M, Zhang ZW, Moon CS, Shimbo S, Watanabe T, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K (2000a) Possible effects of environmental cadmium exposure on kidney function in the Japanese general population. Int Arch Environ Health 73:15–25
Ikeda M, Zhang ZW, Shimbo S, Watanabe T, Nakatsuka H, Moon CS, Matsuda-Inoguchi N, Higashikawa K (2000b) Exposure of women in general populations to lead via food and air in east and Southeast Asia. Am J Ind Med 38:271–280
Ikeda M, Zhang ZW, Shimbo S, Watanabe T, Nakatsuka H, Moon CS, Matsuda-Inoguchi N, Higashikawa K (2000c) Urban population exposure to lead and cadmium in East and Southeast Asia. Sci Total Environ 249:373–384
Ikeda M, Ezaki T, Tsukahara T, Morguchi J (2004) Dietary cadmium intake in polluted and non-polluted areas in Japan in the past and in the present. 2004. Int Arch Occup Environ Health 77:227–234
Iqbal S, Muntner P, Batuman V, Rabito FA (2008) Estimated burden of blood lead levels 5 micro g/dl in 1999–2002 and declines from 1988 to 1994. Environ Res 107:305–311
Jarup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182
Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M (1998) Health effects of cadmium exposure-a review of the literature and a risk estimate. Scand J Work Environ Health 24(Suppl 1):1–51
Jeong HS, Lee DB, Cho YC (1991) A study on the blood lead and cadmium concentration levels of rural residents. Res Rep Env Sci Tech Chungnam Univ 9:61–73
Karouna-Renier N, Rao KR, Lanzai JL, Rivers SD, Wilson PA, Hodges DK (2008) Mercury levels and fish consumption practices in women of childbearing age in the Florida Panhandle. Environ Res 103:320–326
Kim H, Cho SH (1994) Estimation of the geometric means and the reference values of blood lead levels among Koreans. J Kor Med Sci 9:304–312
Kim DI, Kim YK, Kim JM, Jung KY, Kim JY, Chang HS, Lee YH, Choi AH (1992) The levels of blood lead and zinc protoporphyrin for healthy urban population in Korea. Korean J Prev Med 25(3):5–22
Kim EK, Ki KI, Kwon JY, Koo JS, Hwang HS, Kim SK, Park YW, Noh JH, Lee DH (2005) The effect of fish consumption on blood mercury level in pregnant women. Korean J Obstet Gynecol 48:2527–2534
Kim SM, Han JH, Park HS (2006) Prevalence of low HDL-cholesterol levels and associated factors among Koreans. Circ J 70:820–826
Kim NS, Choi SW, Kim JH, Ham JO, Park HY, Ahn KD, Lee BK (2007) Bone and blood lead levels of middle aged Korean not occupationally exposed to lead. Korean J Occup Environ Med 19:285–292
Korea Consumer Agency (2002) Report on safety of wooden toy for infant education. Korea Consumer Agency, Seoul
Korean Ministry of Environment (2004) Final report on the health effect of closed mine of Kosung area in Kyungnam Province. Korean Ministry of Environment, Seoul
Korean Ministry of Environment (2005) Seoul: report on the study of blood heavy metals of general population. Korean Ministry of Environment, Seoul
Korean Ministry of Health and Welfare (2005) The third Korean National Health and Nutrition Examination Survey. Korean Ministry of Health and Welfare, Seoul
Kurihara I, Kobayashi E, Uetani M, Inaba T, Oishiz M, Kido T, Nakagawa H, Nogawa K (2004) Association between exposure to cadmium and blood pressure in Japanese peoples. Arch Environ Health 59:711–716
Lee BK (1999) The role of biological monitoring in the health management of lead-exposed workers. Toxicol Lett 108:149–160
Link B, Gabrio T, Piechotowski I, Zollner I, Schwenk M (2006) Baden-Wuerttemberg Environmental Health Survey (BW_EHS) from 1996 to 2003: toxic metals in blood and urine of children. Int J Hyg Environ Health 210:357–371
Mahaffey KR, Mergler D (1998) Blood levels of total and organic mercury in residents of the upper St. Lawrence River basin, Quebec: association with age, gender, and fish consumption. Envrion Res 77:104–114
Mahaffey KR, Clickner RP, Bodurow CC (2004) Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ Health Perspect 112:562–570
Mahaffey KR, Clickner RP, Jeffries RA (2009) Adult women’s blood mercury concentrations vary regionally in the United States: association with patterns of fish consumption (NHANES 1999–2004). Environ Health Perspect 117:47–53
McKelvey W, Gwynn RC, Jeffery N, Kass D, Thorpe LE, Garg RK, Palmer CD, Parsons PJ (2007) A biomonitoring study of lead, cadmium, and mercury in the blood of New York City adults. Environ Health Perspect 115:1435–1441
Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E (2006) Blood lead below 0.48 μmol /L (10 μg/dL) and mortality among US adults. Circulation 114:1388–1394
Moon CS, Zhang ZW, Shimbo S, Watanabe T, Moon DH, Lee CU, Lee BK, Ahn KD, Lee SH, Ikeda M (1995) Dietary intake of cadmium and lead among the general population in Korea. Environ Res 71:46–54
Moon CS, Paik JM, Choi CS, Kim DH, Ikeda M (2003) Lead and cadmium levels in daily foods, blood and urine in children and their mothers in Korea. Int Arch Occup Environ Health 76:282–288
Mozaffarian D, Rimm EB (2006) Fish intake, contaminants, and human health: Evaluating the risks and the benefits. JAMA 296:1885–1899
Muntner P, Menke A, DeSalvo KB, Rabito FA, Batuman V (2005) Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys. Arch Intern Med 165(18):2155–2161
Navas-Acien A, Selvin E, Sharrett R, Calderon-Aranda E, Silbergeld E, Guallar E (2004) Lead, cadmium, smoking and increased risk of peripheral arterial disease. Circulation 109:3196–3201
Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A (2002) Cadmium in blood and urine-impact of sex, age, dietary intake, iron status, and former smoking- association of renal effects. Environ Health Perspect 110:1185–1190
Park SW, Kim KY, Kim DW, Choi SJ, Kim HS, Choi BS, Choi MK, Park JD (2006) The relation between blood lead concentration and epidemiologic factors and body iron status. J Environ Toxicol 21:153–162
Park JU, Oh SW, Kim SH, Kim YH, Park RJ, Moon JD (2008) A study on the association between blood lead levels and habitual tobacco and alcohol use in Koreans with no occupational lead exposure. Korean J Occup Environ Med 20:165–173
Park RJ, Kim SH, Park JU, Kim YH, Kim MB, Park WJ, Moon JD (2009) Blood lead levels as a predictor of coronary artery disease. Korean J Occup Environ Med 21:38–45
Pirkle JL, Brody DJ, Gunter EW, Kramer RA, Paschal DC, Flegal KM et al (1994) The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES). JAMA 272(4):284–291
Reeves PG, Chaney RL (2008) Bioavailability as an issue in risk assessment and management of food cadmium: A review. Sci Total Environ 393:13–19
Sakamoto M, Kaneoka T, Murata K, Nakai K, Satoh H, Akagi H (2007) Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population. Environ Res 103:106–111
Sanzo JM, Dorronsoro M, Amiano P, Amurrio A, Aguinagalde FX, Azpiri MA, The Epic Group of Spain (2001) Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain. Public Health Nutr 4:981–988
Saraiva MCO, Taichman RS, Braun T, Nriagu J, Eklund SA, Burt BA (2007) Lead exposure and periodontitis in US adults. J Periodont Res 42:45–52
Schrober SE, Sinks TH, Jones RL, Bolger PM, McDowell M, Osterloh J, Garrett ES, Canady RA, Dillon CF, Sun Y, Joseph CB, Mahaffey KR (2003) Blood mercury levels in US children and women of childbearing age, 1999–2000. JAMA 289:1667–1674
Schulz C, Becker CK, Kolossa-Gehring M, Seiwert M, Seifert B (2007) Twenty years of the German Environmental Survey (GerES): Human biomonitoring: temporal and spatial (West Germany/East Germany) differences in population exposure. Int J Hyg Environ Health 210:271–297
Seifert B, Becker K, Helm D, Krause C, Schulz C, Seiwert M (2000) The German Environmental Survey 1990/1992 (GerES II): reference concentrations of selected environmental pollutants in blood, urine, hair, house dust, drinking water and indoor air. J Expo Anal Environ Epidemiol 10:552–565
Shimbo S, Zhang ZW, Watanabe T, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2001) Cadmium and lead contents in rice and other cereal products in Japan in 1998–2000. Sci Total Environ 281:165–175
Soong YK, Tseng R, Liu C, Lin PW (1991) Lead, cadmium, arsenic, and mercury levels in maternal and fetal cord blood. J Formos Med Assoc 90:59–65
Tellez-Plaza M, Navas-Ancien A, Crainiceanu CM, Guallar E (2008) Cadmium exposure and hypertension in the 1999–2004 national health and nutrition examination survey (NHANES). Environ Health Perspect 116:51–56
Todd AC, Lee BK, Lee GS, Ahn KD, Moshier FL, Schwartz BS (2001) Predictors of DMSA chelatable lead, tibial lead, and blood lead in 802 Korean lead workers. Occup Environ Med 58:73–80
Tsukahara T, Ezaki T, Moriguchi J, Furuki K, Shimbo S, Matsuda-Inoguchi N, Ikeda M (2003a) Rice as the most influential source of cadmium intake among general Japanese population. Sci Total Environ 305:41–45
Tsukahara T, Ezaki T, Moriguchi J, Furuki K, Fukui Y, Ukai S, Okamoto S, Sakurai H, Ikeda M (2003b) No significant effect of iron deficiency on cadmium body burden or kidney dysfunction among women in the general population in Japan. Int Arch Occup Environ Health 76:275–281
Vahter M, Akesson A, Lind B, Bjors U, Schutz A, Berglund M (2000) Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ Res 84(2):186–194
Vahter M, Berglund M, Akesson A, Liden C (2002) Metals and women’s health. Environ Res 88:145–155
Vahter M, Akesson A, Liden C, Ceccatelli S, Berglund M (2007) Gender differences in the disposition and toxicity of metals. Environ Res 104:85–95
Watanabe T, Zhang ZW, Moon CS, Shimbo S, Nakatsuka H, Matsuda-Inoguchi K, Higashikawa K, Ikeda M (2000) Cadmium exposure of women in general populations in Japan during 1991–1997 compared with 1977–1981. Int Arch Environ Health 73:26–34
World Health Organisation (1995) Inorganic lead: environmental health criteria, vol 118. International Programme on Chemical Safety, World Health Organization, Geneva
Yaginuma-Sakurai K, Shimada M, Ohba T, Nakai K, Suzuki K, Kurokawa N, Kameo S, Satoh H (2009) Assessment of exposure to methylmercury in pregnant Japanese women by FFQ. Public Health Nutrition 12:2352–2358
Yassin AS, Martonik JF, Davidson JL (2004) Blood lead levels in U.S. Workers, 1988–1994. J Occup Environ Med 46:720–728
Yeon YY, Ahn KD, Lee BK (1992) Blood and urine cadmium in non-exposed Korean to cadmium. Korean J Occup Environ Med 4(1):70–80
Zhang ZW, Moon CS, Watanabe T, Shimbo S, He FS, Wu YQ, Zhou SF, Su DM, Qu JB, Ikeda M (1997) Background exposure of urban populations to lead and cadmium: comparison between China and Japan. Int Arch Occup Environ Health 69:273–281
Zhang ZW, Shimbo S, Watanabe T, Srianujata S, Banjong O, Chitchumroonchokchai C, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (1999) Non-occupational lead and cadmium exposure of adult women in Bangkok, Thailand. Sci Total Environ 226(1):65–74
Zhang ZW, Moon CS, Shimbo S, Watanabe T, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2000) Further reduction in lead exposure in women in general populations in Japan in the 1990s, and comparison with levels in east and Southeast Asia. Int Arch Occup Environ Health 73:91–97
Conflict of interest statement
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Additional information
An erratum to this article can be found at http://dx.doi.org/10.1007/s00420-010-0572-9
Rights and permissions
About this article
Cite this article
Kim, NS., Lee, BK. National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population. Int Arch Occup Environ Health 84, 53–63 (2011). https://doi.org/10.1007/s00420-010-0522-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00420-010-0522-6