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Dietary cadmium intake in polluted and non-polluted areas in Japan in the past and in the present

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Abstract

Objective

The purpose of this data compilation is to overview past and current dietary exposure (primarily via rice) of general populations to cadmium (Cd) in environmentally polluted and non-polluted areas in Japan, and to compare the levels with counterpart levels in other areas in Asia.

Methods

A literature survey was conducted for publications on this subject, in either Japanese or international languages, since the early 1970s. Most of the studies identified employed the food-duplicate method in combination with atomic absorption spectrometry for Cd determination, although a few studies utilized other methods, such as the market basket method and dithizon-colorimetry.

Results

The highest estimate of dietary Cd intake (Cd-D), 600 μg Cd/day, was reported in the late 1960s for the local population in the Jinzu river basin, where Itai-itai disease had been endemic, and the Cd-D levels were 300 μg/day or higher in other polluted areas. Cd-D dropped to well below 100 μg/day when the polluted soil was replaced in the late 1970s and thereafter. In non-polluted areas, the Cd-D was reported to be approximately 100 μg/day in 1969, followed by a gradual decrease to approximately 40 μg/day in the late 1970s, to reach the current level of less than 30 μg/day. There is a trend of gradual reduction at the rate of 0.3 to 0.6 μg/day per year. Cd from rice accounted for 30 to 40% of the Cd-D in non-polluted areas, but a higher contribution was observed in some polluted areas. Nevertheless, the current Cd-D is still higher than the levels in other rice-dependent populations in east and south-east Asia.

Conclusion

The Cd-D levels reported for polluted areas were in excess of 300 μg Cd/day. Substantial reduction in Cd-D to the level below 100 μg/day was observed after remediation, such as replacement of polluted paddy soil. In non-polluted areas, there has been a gradual decrease in Cd-D in the past 25 years. Nevertheless, the levels in the current intake of the general population in Japan (25 to 30 μg/day, or <1/10 of the levels in polluted areas in the past) is still higher than the levels in other rice-dependent areas in Asia.

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References

  • Acheson KJ, Campbell IT, Edholm OG, Miller DS, Stock MJ (1980) The measurement of food and energy intake in man—an evaluation of some techniques. Am J Clin Nutr 33:1147–1154

    CAS  PubMed  Google Scholar 

  • Chen F, Cole P, Wen L-F, Mi Z-B, Trapido EJ (1994) Estimates of trace element intakes in Chinese farmers. J Nutr 124:196–201

    CAS  PubMed  Google Scholar 

  • Environment Agency of the Government of Japan (1972) Counter-measures against environmental pollution with cadmium (in Japanese). The Environment Agency, Tokyo, pp 167–168

  • Fan J-J, Aoshima K, Katoh T, Teranishi H, Kasuya M (1998) A follow-up study on renal tubular dysfunction in women living in the cadmium-polluted Jinzu river basin in Toyama, Japan. Part 1. Changes in the levels of exposure to cadmium after soil replacement of polluted paddy fields and the related effects on the prognosis of renal tubular dysfunction (in Japanese with English abstract). Jpn J Hyg 53:545–557

    CAS  Google Scholar 

  • Food and Agricultural Organization (1984) Food Balance Sheets, 1979–1981 Average. Food and Agricultural Organization, Rome

  • Fukushima M (1972) Cadmium levels in various food items (in Japanese). Kankyo Hoken Rep 11:22–25

    Google Scholar 

  • Ikeda M, Zhang Z-W, Moon C-S, Imai Y, Watanabe T, Shimbo S, Ma W-C, Lee C-C, Guo Y-LL (1996) Background exposure of general population to cadmium and lead in Tainan City, Taiwan. Arch Environ Contam Toxicol 30:121–126

    Article  CAS  PubMed  Google Scholar 

  • Ikeda M, Zhang Z-W, Shimbo S, Watanabe T, Nakatsuka H, Moon C-S, Matsuda-Inoguchi N, Higashikawa K (2000) Urban population exposure to lead and cadmium in east and south-east Asia. Sci Total Environ 249:373–384

    Article  CAS  PubMed  Google Scholar 

  • Ishizaki A, Fukushima M (1968) Studies on “Itai-itai” disease (review; in Japanese with English abstract). Jpn J Hyg 23:271–285

    CAS  Google Scholar 

  • Ishizaki A, Fukushima, M., Sakamoto M (1969) Distribution of Cd in biological materials. Part. 1 Human hair and rice straw (in Japanese with English abstract). Jpn J Hyg 24:375–379

    CAS  Google Scholar 

  • Ishizaki A, Fukushima M, Sakamoto M (1970) Distribution of Cd in biological materials. Part. 2 Cadmium and zinc contents of foodstuffs (in Japanese with English abstract). Jpn J Hyg 25:207–222

    CAS  Google Scholar 

  • Japan Public Health Association (1970) Report on dietary intake of cadmium in cadmium-polluted areas in Japan (in Japanese). Japan Public Health Association, Tokyo

  • Kitamura S (1972) Cadmium in rice. Role of rice in nutrition for people in Japan; dependency on rice (in Japanese). Japan Rice Association, Tokyo, pp 78–126

  • Ministry of Health and Welfare, the Government of Japan (1970, 1972) National nutritional survey in Japan, 1968 and 1970 (in Japanese). Dai-ichi Shuppan Press, Tokyo

  • Ministry of Health, Labor and Welfare, the Government of Japan (2002) National nutritional survey in Japan, 2000 (in Japanese). Dai-ichi Shuppan Press, Tokyo

  • Moon C-S, Zhang Z-W, Watanabe T, Shimbo S, Nor-Hassim I, Jamal HH, Ikeda M (1996) Non-occupational exposure of Malay women in Kuala Lumpur, Malaysia, to cadmium and lead. Biomarkers 1:81–85

    CAS  Google Scholar 

  • Moon C-S, Zhang Z-W, Shimbo S, Watanabe T, Moon D-H, Lee C-U, Lee B-K, Ahn K-D, Lee S-H, Ikeda M (1998) Evaluation of urinary cadmium and lead as markers of background exposure of middle-aged women in Korea. Int Arch Occup Environ Health 71:251–256

    Article  CAS  PubMed  Google Scholar 

  • Moon C-S, Paik J-M, Choi C-S, Kim D-H, Ikeda M (2003) Lead and cadmium levels in daily food, blood and urine in children and their mothers in Korea. Int Arch Occup Environ Health 76:282–288

    CAS  PubMed  Google Scholar 

  • Moritsugu M, Kobayashi J (1963) Trace metals in biological materials. Part 2. Cadmium in rice (in Japanese). Research in Agricultural Sciences (Nogaku Kenkyu) 50:37–49

    Google Scholar 

  • Nagasaki prefecture (Department of the Environment and the Institute of Public Health) (1984) Report on intake and excretion of heavy metals (including cadmium) among the residents in cadmium-polluted areas in Izuhara Town, Nagasaki prefecture (in Japanese). Office of Nagasaki prefecture, Nagasaki, Japan

  • National Institute of Health Sciences (2002) Total diet survey in Japan (estimation of daily dietary intake of food contaminants, 1977–2001). National Institute of Health Sciences, Tokyo

  • Nriagu JO (1989) A global assessment of natural sources of atmospheric trace elements. Nature 338:47–49

    Article  CAS  Google Scholar 

  • Rivai ID, Koyama H, Suzuki S (1990) Cadmium content in rice and daily intake in various countries. Bull Environ Contam Toxicol 44:910–916

    CAS  PubMed  Google Scholar 

  • Saito H, Takemura S, Harada K, Hara K (eds) (1993) Chronic cadmium poisoning (in Japanese). The Second Department of Medicine, Nagasaki University School of Medicine, Nagasaki, pp 42–43

  • Saito H, Arisawa K, Nakano A, Liu G, Miyazaki M, Nagata Y, Yokoo M, Sakuma T, Tanimura K, Moji K, Takahashi T, Watanabe T, Nishihara J, Tsutsumi K, Yamamoto Y, Hayashima O, Shigaki K (2003) Epidemiological significance of cadmium concentrations in blood and hair as an indicator of total body burden of cadmium among residents in cadmium-polluted areas (in Japanese). Presentation at the annual meeting of the study group on heavy metal toxicology, March 2003, Tokyo, Japan

  • Shimbo S, Zhang Z-W, Watanabe T, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2001) Cadmium and lead contents in rice and other cereal products in Japan in 1998–2000. Sci Total Environ 281:165–175

    PubMed  Google Scholar 

  • Suzuki S (1976) Intake and metabolism of metals in general Japanese population: cadmium (in Japanese). Progress in Medicine (Igaku no Ayumi) 99:150–156

    Google Scholar 

  • Tsuchiya K (1969) Causation of Ouchi-Ouchi disease (Itai-itai byo)—an introductory review. Part I. Nature of the disease. Keio J Med 18:181–194

    CAS  PubMed  Google Scholar 

  • Tsuchiya K, Iwao S (1978) Dietary cadmium intake of residents in cadmium-polluted areas in Akita, Ishikawa and Nagasaki prefectures (in Japanese). Kankyo Hoken Rep 44; 86–115

    Google Scholar 

  • Tsukahara T, Ezaki T, Moriguchi J, Furuki K, Shimbo S, Matsuda-Inoguchi N, Ikeda M (2003) Rice as the most influential source of cadmium intake among general Japanese population. Sci Total Environ 305:41–51

    Article  CAS  PubMed  Google Scholar 

  • Watanabe T, Koizumi A, Fujita H, Kumai M, Ikeda M (1985) Dietary cadmium intakes of farmers in non-polluted areas in Japan, and the relation with blood cadmium levels. Environ Res 37:33–43

    CAS  PubMed  Google Scholar 

  • Watanabe T, Nakatsuka H, Ikeda M (1989) Cadmium and lead contents in rice available in various areas in Asia. Sci Total Environ 80:175–184

    Article  CAS  PubMed  Google Scholar 

  • Watanabe T, Shimbo S, Moon C-S, Zhang Z-W, Ikeda M (1996) Cadmium contents in rice samples from various areas in the world. Sci Total Environ 184:191–196

    Article  CAS  PubMed  Google Scholar 

  • Watanabe T, Zhang Z-W, Qu J-B, Xu G-F, Song L-H, Wang J-J, Shimbo S, Nakatsuka H, Higashikawa K, Ikeda M (1998) Urban–rural comparison on cadmium exposure among general populations in Shandong Province, China. Sci Total Environ 217:1–8

    Article  CAS  PubMed  Google Scholar 

  • Watanabe T, Zhang Z-W, Moon C-S, Shimbo S, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2000a) Cadmium exposure of women in general populations in Japan during 1991–1997 compared with 1977–1981. Int Arch Occup Environ Health 73:26–34

    PubMed  Google Scholar 

  • Watanabe T, Zhang Z-W, Qu J-B, Gao W-P, Jian Z-K, Shimbo S, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2000b) Background lead and cadmium exposure of adult women in Xian City and two farming villages in Shaanxi Province, China. Sci Total Environ 347:1–13

    Article  Google Scholar 

  • World Health Organization (1985) Guidelines for the study of dietary intake of chemical contaminants. WHO offset publication No. 87. World Health Organization, Geneva

  • Yamagata N, Iwashima K (1975) Average cadmium intake of the Japanese people. Bull Inst Public Health 24:18–24

    Google Scholar 

  • Zhang Z-W, Moon C-S, Watanabe T, Shimbo S, He F-S, Wu Y-Q, Zhou S-F, Su D-M, Qu J-B, Ikeda M (1997) Background exposure of urban populations to lead and cadmium; comparison between China and Japan. Int Arch Occup Environ Health 69:273–281

    Article  CAS  PubMed  Google Scholar 

  • Zhang Z-W, Subida RD, Agetano MG, Nakatsuka H, Inoguchi N, Watanabe T, Shimbo S, Higashikawa K, Ikeda M (1998) Non-occupational exposure of adult women in Manila, the Philippines, to lead and cadmium. Sci Total Environ 215:157–165

    Article  CAS  PubMed  Google Scholar 

  • Zhang Z-W, Shimbo S, Watanabe T, Srianujata S, Banjong O, Chitchumroonchokchai C, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (1999) Non-occupational lead and cadmium exposure of adult women in Bangkok, Thailand. Sci Total Environ 226:65–74

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors are grateful to the late Dr. S. Kitamura, Professor Emeritus of Kobe University, Kobe, Japan, for his interest in and support to this study. Thanks are also due to Miss F. Ohashi, Kyoto Industrial Health Association, Kyoto, Japan, for her skillful secretarial work, and to the Japan Public Health Association, Tokyo, for its support in data collection.

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Authors and Affiliations

  1. Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, Kyoto 604-8472, Japan

    Masayuki Ikeda, Takafumi Ezaki, Teruomi Tsukahara & Jiro Moriguchi

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  1. Masayuki Ikeda
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  2. Takafumi Ezaki
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  3. Teruomi Tsukahara
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  4. Jiro Moriguchi
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Correspondence to Masayuki Ikeda.

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Ikeda, M., Ezaki, T., Tsukahara, T. et al. Dietary cadmium intake in polluted and non-polluted areas in Japan in the past and in the present. Int Arch Occup Environ Health 77, 227–234 (2004). https://doi.org/10.1007/s00420-003-0499-5

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