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Choroidal arterial abnormality in central serous chorioretinopathy

  • Retinal Disorders
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Abstract

Purpose

To evaluate the choroidal arterial abnormality in central serous chorioretinopathy (CSC).

Methods

Fifty-two eyes from 52 patients with CSC were retrospectively evaluated. Arterial and venous ultrawide-field indocyanine green angiography were merged after color and transparency adjustments to compare the choroidal arterial and venous vasculature. Specifically, we evaluated whether the choroidal arteries directly fill the pachyvessel without interconnection of choriocapillaris (arterial pachyvessel; aPV). Then, the clinical characteristics of patients with and without arterial pachyvessel were compared.

Results

Pachyvessel under subretinal fluid was detected in 47 of 52 eyes (90.4%). An arterial pachyvessel was detected in eight of 52 eyes (15.4%). Of those eight eyes with arterial pachyvessel, seven (87.5%) showed sustained staining through the venous phase, suggesting they are arteriovenous shunt, while one eye (12.5%) showed diminished fluorescence in the venous phase, suggesting this pachyvessel was purely an artery. Patients with arterial pachyvessel experienced more CSC recurrences (non-aPV group: 2.09 ± 1.44 times vs. aPV group: 3.25 ± 1.28 times; p = 0.039) and pachychoroid neovasculopathy (PNV) development (non-aPV group: 2.3% vs. aPV group: 37.5%, p = 0.009).

Conclusion

The presence of arterial pachyvessel in eyes with CSC may represent choroidal circulatory imbalance and focal shear stress to Bruch’s membrane, leading to a chronic nature and PNV development.

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Authors and Affiliations

  1. Helsinki Retina Research Group, Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Raimo Tuuminen

  2. Department of Ophthalmology, Kymenlaakso Central Hospital, Kotka, Finland

    Raimo Tuuminen

  3. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Raimo Tuuminen

  4. Keye Eye Center, 326 Teheran-Ro, Gangnam-Gu, Seoul, Republic of Korea

    Sohee Jeon

Authors
  1. Raimo Tuuminen
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  2. Sohee Jeon
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Correspondence to Sohee Jeon.

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The research was conducted in accordance with the tenets of the Declaration of Helsinki and approved by the Institutional Review Board (IRB)/Ethics Committee of Keye Eye Center (IRB number P12362378-001).

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Tuuminen, R., Jeon, S. Choroidal arterial abnormality in central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06522-w

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