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Long-term changes of choroidal blood flow velocity in Vogt-Koyanagi-Harada disease

  • Retinal Disorders
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Abstract

Purpose

To evaluate changes in choroidal blood flow in patients with Vogt-Koyanagi-Harada (VKH) disease after initiation of corticosteroid treatment.

Methods

Fourteen patients (10 men and 4 women) with acute VKH disease followed for 2 years were retrospectively reviewed; only right eyes were included in the analysis. Mean blur rate (MBR) in the macula was measured by laser speckle flowgraphy (LSFG) and central choroidal thickness (CCT) was measured by optical coherence tomography (OCT), both prior to treatment and over 2 years after initiation of corticosteroid treatment.

Results

Of 14 patients included in this study, 13 received initial treatment consisting of intravenous corticosteroid pulse therapy and one patient was treated using bilateral sub-Tenon injections of triamcinolone acetonide. Mean percentage change in MBR was significantly increased after initiation of treatment compared to pretreatment values (P < 0.001). Mean CCTs were significantly decreased after initiation of treatment, compared to pretreatment thicknesses (P < 0.001). There was no significant change in either MBR change or CCT at 1 month after initiation of treatment through 2 years of follow-up. The mean MBR percentage change was significantly higher in eyes with sunset glow fundus (SGF) compared to eyes without SGF at 1 year.

Conclusion

With initiation of corticosteroid treatment in VKH disease patients, choroidal blood flow improved and was maintained for 2 years. However, the presence of SGF should be taken into consideration when interpreting MBR results in VKH disease patients.

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Authors and Affiliations

  1. Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani Toyama, Toyama, 930-0194, Japan

    Shinya Abe, Tomoko Nakamura, Erika Okumura, Toshihiko Oiwake & Atsushi Hayashi

  2. Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo, 181-8611, Japan

    Annabelle A. Okada

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  1. Shinya Abe
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  2. Tomoko Nakamura
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  3. Erika Okumura
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  4. Toshihiko Oiwake
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  5. Annabelle A. Okada
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  6. Atsushi Hayashi
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Correspondence to Atsushi Hayashi.

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All procedures involving human participants were in accordance with the ethical standards of the Institutional Review Board of the University of Toyama and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Abe, S., Nakamura, T., Okumura, E. et al. Long-term changes of choroidal blood flow velocity in Vogt-Koyanagi-Harada disease. Graefes Arch Clin Exp Ophthalmol 260, 1933–1939 (2022). https://doi.org/10.1007/s00417-021-05540-2

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  • DOI: https://doi.org/10.1007/s00417-021-05540-2

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