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Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Indocyanine green angiography (IA) is a highly sensitive method to evaluate choroidal inflammatory lesions. We present standardized IA findings of initial acute Vogt-Koyanagi-Harada (VKH) disease in Japanese patients before therapeutical intervention.

Methods

Medical records of patients with VKH disease at Tokyo Medical and Dental University Hospital and Miyata Eye Hospital were retrospectively analyzed. We analyzed six IA signs: choroidal perfusion inhomogeneity, early hyperfluorescent stromal vessels, hypofluorescent dark dots (HDDs), fuzzy or lost pattern of large stromal vessels, disc hyperfluorescence, and diffuse late choroidal hyperfluorescence.

Results

Ten patients from the two hospitals were studied. The most constant findings present in all eyes were early hyperfluorescent stromal vessels, HDDs, and either fuzzy or lost pattern of large stromal vessels. Disc hyperfluorescence was present in 18 eyes. Choroidal perfusion inhomogeneity was seen in six patients, and diffuse late choroidal hyperfluorescence was seen to a certain degree in all eyes.

Conclusions

Four of the analyzed signs, including early hyperfluorescent stromal vessels, HDDs, fuzzy or lost pattern of large stromal vessels, and disc hyperfluorescence were consistent findings in Japanese VKH patients. Because the primary lesion is situated in the choroid, IA is the method of choice to monitor disease activity in VKH disease.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan

    Masaru Miyanaga, Tatsushi Kawaguchi, Shintaro Horie, Manabu Mochizuki & Carl P. Herbort

  2. Miyata Eye Hospital, Miyazaki, Japan

    Masaru Miyanaga & Kazunori Miyata

  3. Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialized Care, Lausanne, Switzerland

    Carl P. Herbort

  4. University of Lausanne, Lausanne, Switzerland

    Carl P. Herbort

  5. Inflammatory and Retinal Eye Disease, Centre for Ophthalmic Specialized Care, 6 Rue de la Grotte, CH-1003, Lausanne, Switzerland

    Carl P. Herbort

Authors
  1. Masaru Miyanaga
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  2. Tatsushi Kawaguchi
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  3. Kazunori Miyata
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  4. Shintaro Horie
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  5. Manabu Mochizuki
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  6. Carl P. Herbort
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Corresponding author

Correspondence to Carl P. Herbort.

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Miyanaga, M., Kawaguchi, T., Miyata, K. et al. Indocyanine green angiography findings in initial acute pretreatment Vogt-Koyanagi-Harada disease in Japanese patients. Jpn J Ophthalmol 54, 377–382 (2010). https://doi.org/10.1007/s10384-010-0853-6

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  • DOI: https://doi.org/10.1007/s10384-010-0853-6

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