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Morphological features of macular telangiectasia type 2 in Japanese patients

  • Retinal Disorders
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Abstract

Purpose

This study aimed to demonstrate the clinical course of Japanese patients with macular telangiectasia type 2 (MacTel-2).

Methods

This retrospective observational case series included 16 eyes of 8 Japanese patients (3 men and 5 women) with MacTel-2. The mean age and follow-up duration was 66.9 years and 42.8 months, respectively. Differences in best-corrected visual acuity (BCVA), funduscopic macular findings, central macular thickness (CMT), and the length of macular ellipsoid zone (EZ) loss were compared between the initial/baseline and final visits. Optical coherence tomographic changes in CMT by ≥ 20% and in EZ loss by ≥ 20% or ≥ 100 μm were defined as improved or worsened.

Results

Numerical changes in BCVA and EZ loss during follow-up were not statistically significant. However, the mean CMT at baseline, which was lower than that of healthy control eyes (P < 0.001), significantly increased during follow-up (P = 0.041). A certain proportion of eyes showed improvement in several parameters: funduscopic findings (both parafoveal retinal graying and foveal retinal pigment epithelium depigmentation) in 29% of eyes, CMT in 21% of eyes, and EZ loss in 43% of eyes.

Conclusions

The non-negligible proportion of eyes with improved parameters, marked especially by macular EZ loss, suggests that Japanese patients with MacTel-2 have milder clinical features than Caucasian patients reported in the literature.

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Data availability

All data generated or analyzed during this study are included in this published article.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan

    Akihiro Shinkai, Wataru Saito, Yuki Hashimoto, Michiyuki Saito, Satoru Kase, Kousuke Noda & Susumu Ishida

  2. Kaimeido Eye and Dental Clinic, Sapporo, Japan

    Wataru Saito

Authors
  1. Akihiro Shinkai
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  2. Wataru Saito
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  3. Yuki Hashimoto
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  4. Michiyuki Saito
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  5. Satoru Kase
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  6. Kousuke Noda
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  7. Susumu Ishida
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Correspondence to Wataru Saito.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The current study was approved by the ethics committee of Hokkaido University Hospital (#018-0207).

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Informed consent was obtained from all individual participants included in the study.

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Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

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Shinkai, A., Saito, W., Hashimoto, Y. et al. Morphological features of macular telangiectasia type 2 in Japanese patients. Graefes Arch Clin Exp Ophthalmol 259, 1179–1189 (2021). https://doi.org/10.1007/s00417-020-04989-x

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  • DOI: https://doi.org/10.1007/s00417-020-04989-x

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