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Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients

  • Neurophthalmology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Aims

To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function.

Methods

A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer.

Results

The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004,< 0.001,< 0.001) and thicker INL thickness (p = 0.012) than did the controls. The mean deviation of preoperative VF in the PA group was positively correlated with RNFL, GCL, and IPL thicknesses (R = 0.664, 0.720, 0.664; p < 0.001,< 0.001,< 0.001) and negatively correlated with the INL thickness (R = −0.400; p = 0.010). Among the 47 eyes, 32 eyes (68%) were included for subgroup analysis. Preoperative RNFL, GCL, and IPL thicknesses were thicker in the postoperatively improved VF group (p = 0.019, 0.009, 0.005). The preoperative cutoff values for visual recovery were 23.6 μm for RNFL thickness, 30.6 μm for GCL thickness, and 28.9 μm for IPL thickness.

Conclusion

During chiasmal compression, the thickening of the INL has presented in addition to thinning of the inner retinal layers. Also, changes in retinal anatomical structures are related to the extent of VF defect and can be used as a predictor of postoperative visual recovery.

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Abbreviations

GC:

Ganglion cell layer

INL:

Inner nuclear layer

IPL:

Inner plexiform layer

MD:

Mean deviation

MS:

Multiple sclerosis

NMO:

Neuromyelitis optica

ONL:

Outer nuclear layer

OPL:

Outer plexiform layer

PA:

Pituitary adenoma

PRL:

Photoreceptor layer

RGCs:

Retinal ganglion cells

RNFL:

Retinal nerve fiber layer

ROC:

Receiver operating characteristic

RPE:

Retinal pigment epithelium

SD-OCT:

Spectral-domain optical coherence tomography

VF:

Visual field

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Funding

This study was funded by Research Fund of Seoul St. Mary’s Hospital, the Catholic University of Korea (No.5–2018-B0001–00006).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, SahmYook Medical Center, 82 Mangu-ro, Dongdaemun-gu, Seoul, 02500, Republic of Korea

    Ji-Sun Moon

  2. Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea

    Sun Young Shin

Authors
  1. Ji-Sun Moon
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Contributions

Conception and design: Moon, Shin. Acquisition of data: Moon. Analysis and interpretation of data: Moon, Shin. Drafting the article: Moon. Critically revising the article: Moon, Shin. Reviewed submitted version of manuscript: Moon, Shin. Approved the final version of the manuscript on behalf of all authors: Shin. Statistical analysis: Moon. Administrative/technical/material support: Moon. Study supervision: Shin.

Corresponding author

Correspondence to Sun Young Shin.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board of the Catholic University of Korea, College of Medicine (approval no. KC18RESI0244), and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The institutional review board waived the need for written consent from the participants, because of the retrospective design. Patient information was anonymized and de-identified prior to analysis.

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Moon, JS., Shin, S.Y. Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients. Graefes Arch Clin Exp Ophthalmol 258, 419–425 (2020). https://doi.org/10.1007/s00417-019-04560-3

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  • DOI: https://doi.org/10.1007/s00417-019-04560-3

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