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Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease

  • Inflammatory Disorders
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Abstract

Purpose

Our purpose was to study changes in macular cone photoreceptors in Vogt-Koyanagi-Harada (VKH) disease patients after high-dose corticosteroid treatment using an adaptive optics (AO) fundus camera.

Methods

We retrospectively analyzed 16 eyes of eight patients with new-onset acute VKH disease that were studied retrospectively. After serous retinal detachment (SRD) had resolved, AO images were obtained using the rtx1™ AO fundus camera over a 12-month course. Cone counting was performed in the nasal, temporal, superior and inferior areas of the macula 0.75 mm from the foveal center. A control group of 30 eyes of 30 healthy subjects was established for comparison.

Results

In the eyes with VKH disease, the mean cone densities 0.75 mm from the foveal center were 11,847 at baseline (resolution of SRD), and 15,218, 16,684 and 17,686 cones/mm2, at 3, 6, and 12 months later, respectively. The mean cone densities at 3, 6, and 12 months were significantly increased compared to those of baseline (p = 0.007, p < 0.001, and p < 0.001, respectively); however, they were significantly lower than that of the healthy control eyes (p < 0.001). The mean cone densities at areas with a previous presence of cystoid spaces were significantly lower than those without cystoid spaces at the baseline, and at 3, 6, and 12 months (p < 0.001, p = 0.007, p < 0.001, and p = 0.008, respectively).

Conclusions

Cone densities were gradually increased after the resolution of SRD in the eyes of VKH disease patients. The presence of cystoid spaces might be a marker of severe damage to cone photoreceptors.

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Authors and Affiliations

  1. Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Tomoko Nakamura, Atsushi Hayashi & Toshihiko Oiwake

Authors
  1. Tomoko Nakamura
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  2. Atsushi Hayashi
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  3. Toshihiko Oiwake
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Corresponding author

Correspondence to Tomoko Nakamura.

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Conflicts of interest

All authors have no financial interest in the subject matter or materials disucussed in this manuscript.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and the national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Nakamura, T., Hayashi, A. & Oiwake, T. Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. Graefes Arch Clin Exp Ophthalmol 256, 387–394 (2018). https://doi.org/10.1007/s00417-017-3869-5

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  • DOI: https://doi.org/10.1007/s00417-017-3869-5

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