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Analysis of autofluorescence pattern in birdshot chorioretinopathy

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To characterize and correlate the different patterns of fundus autofluorescence (FAF) in patients with birdshot chorioretinopathy (BSCR), with functional and anatomical parameters.

Methods

Twenty-one BSCR patients were prospectively studied in 2013 and 2014. Each patient underwent visual acuity (VA) and visual field (SITA standard 30.2) testing as well as fluorescein and indocyanine green angiography, spectral-domain optical coherence tomography (SD-OCT) B scan, enhanced depth imaging (EDI), and fundus autofluorescence (FAF) imaging. The disease was classified as active, chronic, or quiescent.

Results

The patients’ mean age was 60.3 ± 9.2 years and 60% were female. Disease duration was 5.7 ± 3.7 years. Autofluorescence imaging showed punctiform hyper-FAF spots in 23 out of the 29 eyes (79%), which was significantly associated with a greater visual field mean deviation (−7 ± 7 versus −3 ± 2 dB, p = 0.04). Hypo-FAF was defined as peripapillary (n = 25; 86.2%), macular (n = 10; 34.5%), lichenoid (n = 17; 58.6%), and/or diffuse (n = 13; 44.8%). Lichenoid hypo-FAF was significantly associated with worse VA (0.18 ± 0.24 vs. 0.05 ± 0.07 LogMAR, p = 0.04). Macular hypo-FAF was associated with a history of macular edema (62.5%; p = 0.06). Diffuse hypo-FAF was observed more frequently (p = 0.01) in chronic disease (66.7%) than in active (0%) or quiescent disease (27.3%).

Conclusions

Autofluorescence analysis in BRSC patients contributes to evaluating disease activity and could be useful to guide follow-up and treatment.

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Acknowledgments

ARFO (Association for Research and Teaching in Ophthalmology). The sponsor or funding organization had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Department of Ophthalmology, University Hospital, CS10217, Grenoble, F-38043, France

    R. Semécas, F. Aptel, A. Mailhac, L. Salmon & C. Chiquet

  2. Grenoble Alpes University, Grenoble, F-38041, France

    R. Semécas, F. Aptel, A. Mailhac, L. Salmon & C. Chiquet

  3. Rothschild Foundation, 25 rue Manin, 75940, Paris, Cedex 19, France

    M. Mauget-Faÿsse & V. Vasseur

  4. Department of Internal Medicine, University Hospital, Grenoble, France

    L. Bouillet

Authors
  1. R. Semécas
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  2. M. Mauget-Faÿsse
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  3. F. Aptel
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  4. A. Mailhac
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  5. L. Salmon
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  6. V. Vasseur
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  7. L. Bouillet
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  8. C. Chiquet
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Corresponding author

Correspondence to C. Chiquet.

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Funding

ARFO provided financial support. The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Semécas, R., Mauget-Faÿsse, M., Aptel, F. et al. Analysis of autofluorescence pattern in birdshot chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 255, 1333–1339 (2017). https://doi.org/10.1007/s00417-017-3644-7

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  • DOI: https://doi.org/10.1007/s00417-017-3644-7

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